A J M Cooper1, S J Sharp1, R N Luben2, K-T Khaw3, N J Wareham1, N G Forouhi1. 1. MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge School of Clinical Medicine, Cambridge, UK. 2. Department of Public Health and Primary Care, Strangeways Research Laboratory, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival, University of Cambridge, Cambridge, UK. 3. Clinical Gerontology Unit, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Box 251, Cambridge, UK.
Abstract
BACKGROUND/ OBJECTIVES: Biomarkers for a mixed fruit and vegetable (FV) diet are needed to provide a better understanding of the association between FV intake and type 2 diabetes. We aimed to examine the prospective association between a composite score comprised of three biomarkers of FV intake in free-living populations and incident diabetes. SUBJECTS/ METHODS: A total of 318 incident diabetes cases and 926 controls from the EPIC (European Prospective Investigation of Cancer)-Norfolk study aged 40-79 years at baseline (1993-1997), completed 7-day prospective food diary and had plasma vitamin C and carotenoid measures. A composite biomarker score (CB-score) comprising the sum of plasma vitamin C, beta-carotene and lutein was derived. Odds ratios (ORs) and 95% confidence intervals (CIs) for incident diabetes were estimated using multivariable logistic regression. RESULTS: A strong inverse association was found between the CB-score and incident diabetes. The ORs (95% CI) of diabetes comparing quartiles Q2, Q3 and Q4 of the CB-score with Q1 (reference category) were 0.70 (0.49, 1.00), 0.34 (0.23, 0.52) and 0.19 (0.12, 0.32), respectively, and 0.49 (0.40, 0.58) per s.d. change in CB-score in a model adjusted for demographic and lifestyle factors. The association was marginally attenuated after additionally adjusting for body mass index and waist circumference (0.60 (0.49 and 0.74) per s.d. change in CB-score). CONCLUSIONS: A combination of biomarkers representing the intake of a mixed FV diet was strongly inversely associated with incident diabetes. These findings provide further support for measuring dietary biomarkers in studies of diet-disease associations and highlight the importance of consuming FV for the prevention of diabetes.
BACKGROUND/ OBJECTIVES: Biomarkers for a mixed fruit and vegetable (FV) diet are needed to provide a better understanding of the association between FV intake and type 2 diabetes. We aimed to examine the prospective association between a composite score comprised of three biomarkers of FV intake in free-living populations and incident diabetes. SUBJECTS/ METHODS: A total of 318 incident diabetes cases and 926 controls from the EPIC (European Prospective Investigation of Cancer)-Norfolk study aged 40-79 years at baseline (1993-1997), completed 7-day prospective food diary and had plasma vitamin C and carotenoid measures. A composite biomarker score (CB-score) comprising the sum of plasma vitamin C, beta-carotene and lutein was derived. Odds ratios (ORs) and 95% confidence intervals (CIs) for incident diabetes were estimated using multivariable logistic regression. RESULTS: A strong inverse association was found between the CB-score and incident diabetes. The ORs (95% CI) of diabetes comparing quartiles Q2, Q3 and Q4 of the CB-score with Q1 (reference category) were 0.70 (0.49, 1.00), 0.34 (0.23, 0.52) and 0.19 (0.12, 0.32), respectively, and 0.49 (0.40, 0.58) per s.d. change in CB-score in a model adjusted for demographic and lifestyle factors. The association was marginally attenuated after additionally adjusting for body mass index and waist circumference (0.60 (0.49 and 0.74) per s.d. change in CB-score). CONCLUSIONS: A combination of biomarkers representing the intake of a mixed FV diet was strongly inversely associated with incident diabetes. These findings provide further support for measuring dietary biomarkers in studies of diet-disease associations and highlight the importance of consuming FV for the prevention of diabetes.
Authors: Simin Liu; Mary Serdula; Sok-Ja Janket; Nancy R Cook; Howard D Sesso; Walter C Willett; Joann E Manson; Julie E Buring Journal: Diabetes Care Date: 2004-12 Impact factor: 19.112
Authors: W K Al-Delaimy; P Ferrari; N Slimani; V Pala; I Johansson; S Nilsson; I Mattisson; E Wirfalt; R Galasso; D Palli; P Vineis; R Tumino; M Dorronsoro; G Pera; M C Ocké; H B Bueno-de-Mesquita; K Overvad; Mad Chirlaque; A Trichopoulou; A Naska; A Tjønneland; A Olsen; E Lund; E H R Alsaker; A Barricarte; E Kesse; M-C Boutron-Ruault; F Clavel-Chapelon; T J Key; E Spencer; S Bingham; A A Welch; M-J Sanchez-Perez; G Nagel; J Linseisen; J R Quirós; P H M Peeters; C H van Gils; H Boeing; A L van Kappel; J-P Steghens; E Riboli Journal: Eur J Clin Nutr Date: 2005-12 Impact factor: 4.016
Authors: Atsushi Hozawa; David R Jacobs; Michael W Steffes; Myron D Gross; Lyn M Steffen; Duk-Hee Lee Journal: Am J Epidemiol Date: 2006-04-05 Impact factor: 4.897
Authors: M Kataja-Tuomola; J R Sundell; S Männistö; M J Virtanen; J Kontto; D Albanes; J Virtamo Journal: Diabetologia Date: 2007-11-10 Impact factor: 10.122
Authors: M Jenab; E Riboli; P Ferrari; M Friesen; J Sabate; T Norat; N Slimani; A Tjønneland; A Olsen; K Overvad; M-C Boutron-Ruault; F Clavel-Chapelon; H Boeing; M Schulz; J Linseisen; G Nagel; A Trichopoulou; A Naska; E Oikonomou; F Berrino; S Panico; D Palli; C Sacerdote; R Tumino; P H Peeters; M E Numans; H B Bueno-de-Mesquita; F L Büchner; E Lund; G Pera; M D Chirlaque; M-J Sánchez; L Arriola; A Barricarte; J R Quirós; I Johansson; A Johansson; G Berglund; S Bingham; K-T Khaw; N Allen; T Key; F Carneiro; V Save; G Del Giudice; M Plebani; R Kaaks; C A Gonzalez Journal: Br J Cancer Date: 2006-07-11 Impact factor: 7.640
Authors: Ju-Sheng Zheng; Stephen J Sharp; Fumiaki Imamura; Rajiv Chowdhury; Thomas E Gundersen; Marinka Steur; Ivonne Sluijs; Yvonne T van der Schouw; Antonio Agudo; Dagfinn Aune; Aurelio Barricarte; Heiner Boeing; María-Dolores Chirlaque; Miren Dorronsoro; Heinz Freisling; Douae El-Fatouhi; Paul W Franks; Guy Fagherazzi; Sara Grioni; Marc J Gunter; Cecilie Kyrø; Verena Katzke; Tilman Kühn; Kay-Tee Khaw; Nasser Laouali; Giovanna Masala; Peter M Nilsson; Kim Overvad; Salvatore Panico; Keren Papier; J Ramón Quirós; Olov Rolandsson; Daniel Redondo-Sánchez; Fulvio Ricceri; Matthias B Schulze; Annemieke M W Spijkerman; Anne Tjønneland; Tammy Y N Tong; Rosario Tumino; Elisabete Weiderpass; John Danesh; Adam S Butterworth; Elio Riboli; Nita G Forouhi; Nicholas J Wareham Journal: BMJ Date: 2020-07-08
Authors: Tammy Y N Tong; Albert Koulman; Julian L Griffin; Nicholas J Wareham; Nita G Forouhi; Fumiaki Imamura Journal: J Nutr Date: 2020-03-01 Impact factor: 4.798