Xiao-Feng Yu1, Jian Zou1, Jie Dong1. 1. Xiao-Feng Yu, Jian Zou, Jie Dong, Department of Gastroenterology, Huadong Hospital, Fudan University, Shanghai 200040, China.
Abstract
AIM: To assess quantitatively the relationship between fish intake and the incidence of gastrointestinal cancers in a meta-analysis of cohort studies. METHODS: We searched MEDLINE, Embase, Science Citation Index Expanded, and the bibliographies of retrieved articles. Prospective cohort studies were included if they reported relative risks (RRs) and corresponding 95% confidence intervals (CIs) of various cancers with respect to fish intake. When RRs were not available in the published article, they were computed from the exposure distributions. Two investigators extracted the data independently and discrepancies were resolved by discussion with a third investigator. We performed random-effect meta-analyses and meta-regressions of study-specific incremental estimates to determine the risk of cancer associated with a 20-g/d increment of fish consumption. RESULTS: Forty-two studies, comprising 27 independent cohorts, met our inclusion criteria. The studies included 2325040 participants and 24115 incident cases of gastrointestinal cancer, with an average follow-up of 13.6 years. Compared with individuals who did not eat, or seldom ate, fish, the pooled RR of gastrointestinal cancers was 0.93 (95%CI: 0.88-0.98) for regular fish consumers, 0.94 (0.89-0.99) for low to moderate fish consumers, and 0.91 (0.84-0.97) for high fish consumers. Overall, a 20-g increase in fish consumption per day was associated with a 2% reduced risk of gastrointestinal cancers (RR = 0.98; 95%CI: 0.96-1.01). In subgroup analyses, we noted that fish consumption was associated with reduced risk of colorectal (RR = 0.93; 95%CI: 0.87-0.99; P < 0.01), esophageal (RR = 0.91; 95%CI: 0.83-0.99; P < 0.05) and hepatocellular cancers (RR = 0.71; 95%CI: 0.48-0.95; P < 0.01). CONCLUSION: This meta-analysis suggested that fish consumption may reduce total gastrointestinal cancer incidence. Inverse relationships were also detected between fish consumption and specific types of cancers.
AIM: To assess quantitatively the relationship between fish intake and the incidence of gastrointestinal cancers in a meta-analysis of cohort studies. METHODS: We searched MEDLINE, Embase, Science Citation Index Expanded, and the bibliographies of retrieved articles. Prospective cohort studies were included if they reported relative risks (RRs) and corresponding 95% confidence intervals (CIs) of various cancers with respect to fish intake. When RRs were not available in the published article, they were computed from the exposure distributions. Two investigators extracted the data independently and discrepancies were resolved by discussion with a third investigator. We performed random-effect meta-analyses and meta-regressions of study-specific incremental estimates to determine the risk of cancer associated with a 20-g/d increment of fish consumption. RESULTS: Forty-two studies, comprising 27 independent cohorts, met our inclusion criteria. The studies included 2325040 participants and 24115 incident cases of gastrointestinal cancer, with an average follow-up of 13.6 years. Compared with individuals who did not eat, or seldom ate, fish, the pooled RR of gastrointestinal cancers was 0.93 (95%CI: 0.88-0.98) for regular fish consumers, 0.94 (0.89-0.99) for low to moderate fish consumers, and 0.91 (0.84-0.97) for high fish consumers. Overall, a 20-g increase in fish consumption per day was associated with a 2% reduced risk of gastrointestinal cancers (RR = 0.98; 95%CI: 0.96-1.01). In subgroup analyses, we noted that fish consumption was associated with reduced risk of colorectal (RR = 0.93; 95%CI: 0.87-0.99; P < 0.01), esophageal (RR = 0.91; 95%CI: 0.83-0.99; P < 0.05) and hepatocellular cancers (RR = 0.71; 95%CI: 0.48-0.95; P < 0.01). CONCLUSION: This meta-analysis suggested that fish consumption may reduce total gastrointestinal cancer incidence. Inverse relationships were also detected between fish consumption and specific types of cancers.
Entities:
Keywords:
Cancer prevention; Diet; Fish intake; Gastrointestinal cancer
Authors: Anouk Geelen; Jannigje M Schouten; Claudia Kamphuis; Bianca E Stam; Jan Burema; Jacoba M S Renkema; Evert-Jan Bakker; Pieter van't Veer; Ellen Kampman Journal: Am J Epidemiol Date: 2007-09-06 Impact factor: 4.897
Authors: W Chen; J H Weisburger; E S Fiala; T E Spratt; S G Carmella; D Chen; S S Hecht Journal: Chem Res Toxicol Date: 1996 Jan-Feb Impact factor: 3.739
Authors: Jorge E Chavarro; Meir J Stampfer; Hannia Campos; Tobias Kurth; Walter C Willett; Jing Ma Journal: Cancer Epidemiol Biomarkers Prev Date: 2008-01 Impact factor: 4.254
Authors: Le Tran Ngoan; Nguyen Thi Thu; Nguyen Thi Lua; Lai Thi Minh Hang; Nguyen Ngoc Bich; Nguyen Van Hieu; Ha Van Quyet; Le Thi Tai; Do Duc Van; Nguyen Cong Khan; Le Bach Mai; Shinkan Tokudome; Takesumi Yoshimura Journal: Asian Pac J Cancer Prev Date: 2009 Jan-Mar
Authors: Nicole M Niehoff; Emily C Zabor; Jaya Satagopan; Anders Widell; Thomas R O'Brien; Mingdong Zhang; Nathaniel Rothman; Tom K Grimsrud; Stephen K Van Den Eeden; Lawrence S Engel Journal: Environ Res Date: 2020-05-20 Impact factor: 6.498
Authors: Catherine L Callahan; John E Vena; Joseph Green; Mya Swanson; Lina Mu; Matthew R Bonner Journal: Environ Res Date: 2016-12-30 Impact factor: 6.498
Authors: Federica Mazzuca; Marina Borro; Andrea Botticelli; Laura Aimati; Giovanna Gentile; Carlo Capalbo; Chiara Maddalena; Eva Mazzotti; Maurizio Simmaco; Paolo Marchetti Journal: World J Oncol Date: 2015-08-27