| Literature DB >> 25381356 |
Ross M Kedl1, Lawrence J Wysocki2, William J Janssen2, Willi K Born2, Matthew D Rosenbaum2, Julia Granowski2, Jennifer A Kench2, Derek L Fong3, Lisa A Switzer2, Margaret Cruse2, Hua Huang2, Claudia V Jakubzick2, Beata Kosmider2, Katsuyuki Takeda2, Thomas J Stranova2, Randal C Klumm2, Christine Delgado2, Saigiridhar Tummala2, Stijn De Langhe2, John Cambier3, Katherine Haskins3, Laurel L Lenz3, Douglas Curran-Everett2.
Abstract
Changes made in the 8th edition of the Guide for the Care and Use of Laboratory Animals included new recommendations for the amount of space for breeding female mice. Adopting the new recommendations required, in essence, the elimination of trio breeding practices for all institutions. Both public opinion and published data did not readily support the new recommendations. In response, the National Jewish Health Institutional Animal Care and Use Committee established a program to directly compare the effects of breeding format on mouse pup survival and growth. Our study showed an overall parity between trio and pairwise breeding formats on the survival and growth of the litters, suggesting that the housing recommendations for breeding female mice as stated in the current Guide for the Care and Use of Laboratory Animals should be reconsidered.Entities:
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Year: 2014 PMID： 25381356 PMCID： PMC4440340 DOI： 10.4049/jimmunol.1402306
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422