Literature DB >> 2537960

Dual enhancer activities of the cyclic-AMP responsive element with cell type and promoter specificity.

C Kanei-Ishii1, S Ishii.   

Abstract

The role of the cyclic-AMP (cAMP) responsive element (CRE) in eukaryotic gene transcription was investigated in several cell lines transfected by constructs containing the chloramphenicol acetyltransferase (CAT) gene linked to the three different promoters, simian virus (SV) 40, human c-Ha-ras-1, or chicken beta-actin promoter, with or without CRE. CRE had inducible enhancer activity only when it was linked to the SV40 promoter and in a few cell lines such as PC12. CRE functioned as a constitutive enhancer with the human c-Ha-ras-1 promoter in all cell lines examined. CRE also had constitutive enhancer activity when it was linked to the chicken beta-actin promoter, but this activity was observed only in KB, HeLa, and A431 cells. The different types of enhancer activities of CRE depending on the cell and promoter may be caused by interaction with different trans-acting factors that were demonstrated by gel retardation analyses.

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Year:  1989        PMID： 2537960      PMCID： PMC331819          DOI： 10.1093/nar/17.4.1521

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  27 in total

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Authors:  L A Laimins; P Gruss; R Pozzatti; G Khoury
Journal:  J Virol       Date:  1984-01       Impact factor: 5.103

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Authors:  A Seiler-Tuyns; J D Eldridge; B M Paterson
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

6.  Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.

Authors:  J D Dignam; R M Lebovitz; R G Roeder
Journal:  Nucleic Acids Res       Date:  1983-03-11       Impact factor: 16.971

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Authors:  D Gidoni; W S Dynan; R Tjian
Journal:  Nature       Date:  1984 Nov 29-Dec 5       Impact factor: 49.962

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Authors:  C M Gorman; L F Moffat; B H Howard
Journal:  Mol Cell Biol       Date:  1982-09       Impact factor: 4.272

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Authors:  J P Hoeffler; T E Meyer; Y Yun; J L Jameson; J F Habener
Journal:  Science       Date:  1988-12-09       Impact factor: 47.728

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Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162
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  7 in total

1.  ATF-1CREB heterodimer is involved in constitutive expression of the housekeeping Na,K-ATPase alpha 1 subunit gene.

Authors:  M Kobayashi; K Kawakami
Journal:  Nucleic Acids Res       Date:  1995-08-11       Impact factor: 16.971

2.  The cellular transcription factor CREB corresponds to activating transcription factor 47 (ATF-47) and forms complexes with a group of polypeptides related to ATF-43.

Authors:  H C Hurst; N Masson; N C Jones; K A Lee
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

3.  Identification of cis- and trans-acting factors regulating the expression of rat salivary-specific RP4 gene.

Authors:  H H Lin; D K Ann
Journal:  Gene Expr       Date:  1992

4.  Involvement of tyrosine kinase and protein kinase C in platelet-activating-factor-induced c-fos gene expression in A-431 cells.

Authors:  Y B Tripathi; R W Lim; S Fernandez-Gallardo; J C Kandala; R V Guntaka; S D Shukla
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857

5.  Identification and functional characterisation of the cellular activating transcription factor 43 (ATF-43) protein.

Authors:  H C Hurst; N F Totty; N C Jones
Journal:  Nucleic Acids Res       Date:  1991-09-11       Impact factor: 16.971

6.  Cyclic AMP response element-binding protein and the catalytic subunit of protein kinase A are present in F9 embryonal carcinoma cells but are unable to activate the somatostatin promoter.

Authors:  N Masson; M Ellis; S Goodbourn; K A Lee
Journal:  Mol Cell Biol       Date:  1992-03       Impact factor: 4.272

7.  Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain.

Authors:  T Maekawa; H Sakura; C Kanei-Ishii; T Sudo; T Yoshimura; J Fujisawa; M Yoshida; S Ishii
Journal:  EMBO J       Date:  1989-07       Impact factor: 11.598
  7 in total

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