Linda M Liao1, Jonathan N Hofmann1, Farin Kamangar2, Paul T Strickland3, Bu-Tian Ji1, Gong Yang4, Hong-Lan Li5, Nathaniel Rothman1, Wei Zheng4, Wong-Ho Chow6, Yu-Tang Gao5, Xiao-Ou Shu4. 1. Division of Cancer Epidemiology and Genetics, National Cancer Institute Bethesda, MD, USA. 2. Department of Public Health Analysis, School of Community Health and Policy, Morgan State University Baltimore, MD, USA. 3. Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health Baltimore, MD, USA. 4. Department of Medicine, School of Medicine, Vanderbilt University Nashville, TN, USA. 5. Department of Epidemiology, Shanghai Cancer Institute Shanghai, China. 6. Department of Epidemiology, The University of Texas, MD Anderson Cancer Center Houston, TX, USA.
Abstract
PURPOSE: Polycyclic aromatic hydrocarbons (PAHs) are byproducts of incomplete combustion of organic materials. Sources include tobacco smoke, charbroiled meat, and air pollution. Indirect evidence suggests that PAHs may be associated with carcinogenesis, but the association with gastric cancer is unclear. METHODS: Using a nested case-control study design, we examined prediagnostic urinary concentrations of 1-hydroxypyrene glucuronide (1-OHPG), a PAH metabolite, in 153 gastric cancer cases and 306 matched controls within the Shanghai Women's Health Study. Conditional logistic regression adjusted for potential risk factors was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: Urinary 1-OHPG concentrations were slightly higher among cases than controls, with medians of 0.29 μmol/mol Cr (interquartile range, 0.16-0.48) and 0.24 μmol/mol Cr (interquartile range, 0.12-0.45), respectively. Increasing concentrations of 1-OHPG appeared to be associated with elevated risk of gastric cancer, but not within the highest category of 1-OHPG (Q4 vs Q1: OR = 1.4; 95% CI = 0.8-2.5). CONCLUSIONS: Our findings suggest that higher concentrations of 1-OHPG are related to gastric cancer risk, but no clear dose-response relationship was observed.
PURPOSE:Polycyclic aromatic hydrocarbons (PAHs) are byproducts of incomplete combustion of organic materials. Sources include tobacco smoke, charbroiled meat, and air pollution. Indirect evidence suggests that PAHs may be associated with carcinogenesis, but the association with gastric cancer is unclear. METHODS: Using a nested case-control study design, we examined prediagnostic urinary concentrations of 1-hydroxypyrene glucuronide (1-OHPG), a PAH metabolite, in 153 gastric cancer cases and 306 matched controls within the Shanghai Women's Health Study. Conditional logistic regression adjusted for potential risk factors was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: Urinary 1-OHPG concentrations were slightly higher among cases than controls, with medians of 0.29 μmol/mol Cr (interquartile range, 0.16-0.48) and 0.24 μmol/mol Cr (interquartile range, 0.12-0.45), respectively. Increasing concentrations of 1-OHPG appeared to be associated with elevated risk of gastric cancer, but not within the highest category of 1-OHPG (Q4 vs Q1: OR = 1.4; 95% CI = 0.8-2.5). CONCLUSIONS: Our findings suggest that higher concentrations of 1-OHPG are related to gastric cancer risk, but no clear dose-response relationship was observed.
Authors: Amanda J Cross; Neal D Freedman; Jiansong Ren; Mary H Ward; Albert R Hollenbeck; Arthur Schatzkin; Rashmi Sinha; Christian C Abnet Journal: Am J Gastroenterol Date: 2010-10-26 Impact factor: 10.864
Authors: P T Strickland; D Kang; E D Bowman; A Fitzwilliam; T E Downing; N Rothman; J D Groopman; A Weston Journal: Carcinogenesis Date: 1994-03 Impact factor: 4.944
Authors: Jonathan N Hofmann; Linda M Liao; Paul T Strickland; Xiao-Ou Shu; Gong Yang; Bu-Tian Ji; Hong-Lan Li; Nathaniel Rothman; Farin Kamangar; Yu-Tang Gao; Wei Zheng; Wong-Ho Chow Journal: BMC Cancer Date: 2013-06-11 Impact factor: 4.430
Authors: Jason Y Y Wong; Roel Vermeulen; Yufei Dai; Wei Hu; W Kyle Martin; Sarah H Warren; Hannah K Liberatore; Dianzhi Ren; Huawei Duan; Yong Niu; Jun Xu; Wei Fu; Kees Meliefste; Jufang Yang; Meng Ye; Xiaowei Jia; Tao Meng; Bryan A Bassig; H Dean Hosgood; Jiyeon Choi; Mohammad L Rahman; Douglas I Walker; Yuxin Zheng; Judy Mumford; Debra T Silverman; Nathaniel Rothman; David M DeMarini; Qing Lan Journal: Environ Mol Mutagen Date: 2021-08-16 Impact factor: 3.579