Literature DB >> 2537624

Unexpected influence of ionic strength on branched-pathway interactions between beta-lactamases and beta-halogenopenicillanates.

F De Meester1, A Matagne, G Dive, J M Frère.   

Abstract

Ionic strength strongly influenced the turnover/inactivation ratio in the interaction between beta-halogenopenicillanates and some class A beta-lactamases. This suggested the stabilization of a highly charged intermediate by solvation. Those data could be interpreted on the basis of a reaction pathway where an episulphonium ion was transiently formed. The various mechanisms proposed for explaining the formation of the dihydrothiazine chromophore are discussed.

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Year:  1989        PMID： 2537624      PMCID： PMC1135562          DOI： 10.1042/bj2570245

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  16 in total

1.  6-beta-bromopenicillanic acid, a potent beta-lactamase inhibitor.

Authors:  R F Pratt; M J Loosemore
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

2.  The active sites of the beta-lactamases of Streptomyces cacaoi and Streptomyces albus G.

Authors:  F De Meester; B Joris; M V Lenzini; P Dehottay; T Erpicium; J Dusart; D Klein; J M Ghuysen; J M Frère; J Van Beeumen
Journal:  Biochem J       Date:  1987-06-01       Impact factor: 3.857

3.  Beta-lactamase (Bacillus cereus).

Authors:  D R Thatcher
Journal:  Methods Enzymol       Date:  1975       Impact factor: 1.600

4.  Fate of thiazolidine ring during fragmentation of penicillin by exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R61.

Authors:  J Frere; J Ghuysen; H Vanderhaeghe; P Adriaens; J Degelaen; J De Graeve
Journal:  Nature       Date:  1976-04-01       Impact factor: 49.962

5.  On the chemistry of beta-lactamase inhibition by 6 beta-bromopenicillanic acid.

Authors:  B S Orlek; P G Sammes; V Knott-Hunziker; S G Waley
Journal:  J Chem Soc Perkin 1       Date:  1980

6.  Fragmentation of penicillin catalysed by the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces strain r61. Isotopic study of hydrogen fixation on carbon 6.

Authors:  J M Frère; J M Ghuysen; J de Graeve
Journal:  FEBS Lett       Date:  1978-04-01       Impact factor: 4.124

7.  Interaction of clavulanate with the beta-lactamases of Streptomyces albus G and Actinomadura R39.

Authors:  J M Frère; C Dormans; V M Lenzini; C Duyckaerts
Journal:  Biochem J       Date:  1982-12-01       Impact factor: 3.857

8.  Molecular weight, amino acid composition and physicochemical properties of the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R39.

Authors:  J M Frère; R Moreno; J M Ghuysen
Journal:  Biochem J       Date:  1974-10       Impact factor: 3.857

9.  Inactivation of RTEM beta-lactamase from Escherichia coli by clavulanic acid and 9-deoxyclavulanic acid.

Authors:  R L Charnas; J R Knowles
Journal:  Biochemistry       Date:  1981-05-26       Impact factor: 3.162

10.  Inactivation of Bacillus cereus beta-lactamase I by 6 beta-bromopencillanic acid: mechanism.

Authors:  S A Cohen; R F Pratt
Journal:  Biochemistry       Date:  1980-08-19       Impact factor: 3.162
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  5 in total

1.  Kinetic study of interaction between BRL 42715, beta-lactamases, and D-alanyl-D-alanine peptidases.

Authors:  A Matagne; P Ledent; D Monnaie; A Felici; M Jamin; X Raquet; M Galleni; D Klein; I François; J M Frère
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191

2.  Interactions between active-site-serine beta-lactamases and compounds bearing a methoxy side chain on the alpha-face of the beta-lactam ring: kinetic and molecular modelling studies.

Authors:  A Matagne; J Lamotte-Brasseur; G Dive; J R Knox; J M Frère
Journal:  Biochem J       Date:  1993-08-01       Impact factor: 3.857

3.  Kinetic and physical studies of beta-lactamase inhibition by a novel penem, BRL 42715.

Authors:  T H Farmer; J W Page; D J Payne; D J Knowles
Journal:  Biochem J       Date:  1994-11-01       Impact factor: 3.857

4.  Structural basis of the inhibition of class A beta-lactamases and penicillin-binding proteins by 6-beta-iodopenicillanate.

Authors:  Eric Sauvage; Astrid Zervosen; Georges Dive; Raphael Herman; Ana Amoroso; Bernard Joris; Eveline Fonzé; Rex F Pratt; André Luxen; Paulette Charlier; Frédéric Kerff
Journal:  J Am Chem Soc       Date:  2009-10-28       Impact factor: 15.419

5.  Interactions between active-site-serine beta-lactamases and mechanism-based inactivators: a kinetic study and an overview.

Authors:  A Matagne; M F Ghuysen; J M Frère
Journal:  Biochem J       Date:  1993-11-01       Impact factor: 3.857
  5 in total

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