Literature DB >> 2536900

Designing CD4 immunoadhesins for AIDS therapy.

D J Capon1, S M Chamow, J Mordenti, S A Marsters, T Gregory, H Mitsuya, R A Byrn, C Lucas, F M Wurm, J E Groopman.   

Abstract

A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic use.

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Year:  1989        PMID： 2536900     DOI： 10.1038/337525a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  130 in total

1.  Analysis of competition binding between soluble and membrane-bound ligands for cell surface receptors.

Authors:  P Li; P Selvaraj; C Zhu
Journal:  Biophys J       Date:  1999-12       Impact factor: 4.033

2.  Identification of cell surface receptors for the 86-kilodalton glycoprotein of human cytomegalovirus.

Authors:  S Keay; T C Merigan; L Rasmussen
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

Review 3.  Antiretroviral therapy: strategies beyond single-agent reverse transcriptase inhibition.

Authors:  K J Connolly; S M Hammer
Journal:  Antimicrob Agents Chemother       Date:  1992-03       Impact factor: 5.191

Review 4.  Future prospects in antiviral therapy.

Authors:  E H Wiltink
Journal:  Pharm Weekbl Sci       Date:  1992-08-21

5.  Crystal structure of an HIV-binding recombinant fragment of human CD4.

Authors:  S E Ryu; P D Kwong; A Truneh; T G Porter; J Arthos; M Rosenberg; X P Dai; N H Xuong; R Axel; R W Sweet
Journal:  Nature       Date:  1990-11-29       Impact factor: 49.962

6.  Characterization of in vitro inhibition of human immunodeficiency virus by purified recombinant CD4.

Authors:  R A Byrn; I Sekigawa; S M Chamow; J S Johnson; T J Gregory; D J Capon; J E Groopman
Journal:  J Virol       Date:  1989-10       Impact factor: 5.103

7.  Interaxonal Eph-ephrin signaling may mediate sorting of olfactory sensory axons in Manduca sexta.

Authors:  Megumi Kaneko; Alan Nighorn
Journal:  J Neurosci       Date:  2003-12-17       Impact factor: 6.167

8.  Pharmacokinetic analysis and cellular distribution of the anti-HIV compound succinylated human serum albumin (Suc-HSA) in vivo and in the isolated perfused rat liver.

Authors:  R W Jansen; P Olinga; G Harms; D K Meijer
Journal:  Pharm Res       Date:  1993-11       Impact factor: 4.200

9.  Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG.

Authors:  A Trkola; A B Pomales; H Yuan; B Korber; P J Maddon; G P Allaway; H Katinger; C F Barbas; D R Burton; D D Ho
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

10.  Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding.

Authors:  R Wyatt; J Moore; M Accola; E Desjardin; J Robinson; J Sodroski
Journal:  J Virol       Date:  1995-09       Impact factor: 5.103
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