Literature DB >> 2247146

Crystal structure of an HIV-binding recombinant fragment of human CD4.

S E Ryu1, P D Kwong, A Truneh, T G Porter, J Arthos, M Rosenberg, X P Dai, N H Xuong, R Axel, R W Sweet.   

Abstract

CD4 glycoprotein on the surface of T cells helps in the immune response and is the receptor for HIV infection. The structure of a soluble fragment of CD4 determined at 2.3 A resolution reveals that the molecule has two intimately associated immunoglobulin-like domains. Residues implicated in HIV recognition by analysis of mutants and antibody binding are salient features in domain D1. Domain D2 is distinguished by a variation on the beta-strand topologies of antibody domains and by an intra-sheet disulphide bridge.

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Year:  1990        PMID： 2247146      PMCID： PMC5638305          DOI： 10.1038/348419a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  48 in total

1.  Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs.

Authors:  J M Turner; M H Brodsky; B A Irving; S D Levin; R M Perlmutter; D R Littman
Journal:  Cell       Date:  1990-03-09       Impact factor: 41.582

2.  Molecular characteristics of recombinant human CD4 as deduced from polymorphic crystals.

Authors:  P D Kwong; S E Ryu; W A Hendrickson; R Axel; R M Sweet; G Folena-Wasserman; P Hensley; R W Sweet
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

3.  Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding.

Authors:  L K Clayton; M Sieh; D A Pious; E L Reinherz
Journal:  Nature       Date:  1989-06-15       Impact factor: 49.962

4.  The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.

Authors:  P J Maddon; D R Littman; M Godfrey; D E Maddon; L Chess; R Axel
Journal:  Cell       Date:  1985-08       Impact factor: 41.582

5.  A predicted three-dimensional structure for the human immunodeficiency virus binding domains of CD4 antigen.

Authors:  P A Bates; M J McGregor; S A Islam; Q J Sattentau; M J Sternberg
Journal:  Protein Eng       Date:  1989-10

6.  Structure and expression of the human and mouse T4 genes.

Authors:  P J Maddon; S M Molineaux; D E Maddon; K A Zimmerman; M Godfrey; F W Alt; L Chess; R Axel
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

7.  Binding site for human immunodeficiency virus coat protein gp120 is located in the NH2-terminal region of T4 (CD4) and requires the intact variable-region-like domain.

Authors:  N E Richardson; N R Brown; R E Hussey; A Vaid; T J Matthews; D P Bolognesi; E L Reinherz
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

8.  Influence of solvent accessibility and intermolecular contacts on atomic mobilities in hemerythrins.

Authors:  S Sheriff; W A Hendrickson; R E Stenkamp; L C Sieker; L H Jensen
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

9.  Enzymatic cleavage of a CD4 immunoadhesin generates crystallizable, biologically active Fd-like fragments.

Authors:  S M Chamow; D H Peers; R A Byrn; M G Mulkerrin; R J Harris; W C Wang; P J Bjorkman; D J Capon; A Ashkenazi
Journal:  Biochemistry       Date:  1990-10-23       Impact factor: 3.162

10.  The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus.

Authors:  A G Dalgleish; P C Beverley; P R Clapham; D H Crawford; M F Greaves; R A Weiss
Journal:  Nature       Date:  1984 Dec 20-1985 Jan 2       Impact factor: 49.962
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  138 in total

Review 1.  Adding the third dimension to virus life cycles: three-dimensional reconstruction of icosahedral viruses from cryo-electron micrographs.

Authors:  T S Baker; N H Olson; S D Fuller
Journal:  Microbiol Mol Biol Rev       Date:  1999-12       Impact factor: 11.056

2.  Interaction of the poliovirus receptor with poliovirus.

Authors:  Y He; V D Bowman; S Mueller; C M Bator; J Bella; X Peng; T S Baker; E Wimmer; R J Kuhn; M G Rossmann
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-04       Impact factor: 11.205

3.  Energetics of the HIV gp120-CD4 binding reaction.

Authors:  D G Myszka; R W Sweet; P Hensley; M Brigham-Burke; P D Kwong; W A Hendrickson; R Wyatt; J Sodroski; M L Doyle
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-01       Impact factor: 11.205

4.  Proposed acquisition of an animal protein domain by bacteria.

Authors:  P Bork; R F Doolittle
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-01       Impact factor: 11.205

5.  Mutagenic stabilization and/or disruption of a CD4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoprotein.

Authors:  Shi-Hua Xiang; Peter D Kwong; Rishi Gupta; Carlo D Rizzuto; David J Casper; Richard Wyatt; Liping Wang; Wayne A Hendrickson; Michael L Doyle; Joseph Sodroski
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103

6.  Engineering of single Ig superfamily domain of intercellular adhesion molecule 1 (ICAM-1) for native fold and function.

Authors:  Róisín M Owens; Xiaoling Gu; Miran Shin; Timothy A Springer; Moonsoo M Jin
Journal:  J Biol Chem       Date:  2010-03-19       Impact factor: 5.157

7.  Inhibition of HIV infectivity by a natural human isolate of Lactobacillus jensenii engineered to express functional two-domain CD4.

Authors:  Theresa L-Y Chang; Chia-Hwa Chang; David A Simpson; Qiang Xu; Patrick K Martin; Laurel A Lagenaur; Gary K Schoolnik; David D Ho; Sharon L Hillier; Mark Holodniy; John A Lewicki; Peter P Lee
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-12       Impact factor: 11.205

8.  Functional epitope analysis of the human CD4 molecule: antibodies that inhibit human immunodeficiency virus type 1 gene expression bind to the immunoglobulin CDR3-like region of CD4.

Authors:  M Benkirane; M Hirn; D Carrière; C Devaux
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

9.  The cytoplasmic tail of CD4 is required for inhibition of human immunodeficiency virus type 1 replication by antibodies that bind to the immunoglobulin CDR3-like region in domain 1 of CD4.

Authors:  M Benkirane; H Schmid-Antomarchi; D R Littman; M Hirn; B Rossi; C Devaux
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

Review 10.  The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection.

Authors:  S Bour; R Geleziunas; M A Wainberg
Journal:  Microbiol Rev       Date:  1995-03
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