| Literature DB >> 25360759 |
Seitetsu L Lee1, Hideki Hashimoto2, Takahide Kohro3, Hiromasa Horiguchi4, Daisuke Koide5, Issei Komuro1, Kiyohide Fushimi6, Tsutomu Yamazaki7, Hideo Yasunaga8.
Abstract
BACKGROUND: Universal health-care coverage has attracted the interest of policy makers as a way of achieving health equity. However, previous reports have shown that despite universal coverage, socioeconomic disparity persists in access to high-tech invasive care, such as cardiac treatment. In this study, we aimed to investigate the association between socioeconomic status and care of aortic stenosis in the context of Japan's health-care system, which is mainly publicly funded.Entities:
Mesh:
Year: 2014 PMID: 25360759 PMCID: PMC4215927 DOI: 10.1371/journal.pone.0111071
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Patient and institutional characteristics by municipality-level mean income strata (all patients).
| Municipality-level mean income (lowest to highest) | ||||||
| n = 12,893 | 1st | 2nd | 3rd | 4th |
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| Number of symptomatic AS patients | 3,228 | 3,183 | 3,172 | 3,310 | ||
| Age | ≥75 | 70.0% | 70.2% | 65.9% | 66.1% | <0.001 |
| Female | 58.3% | 60.7% | 57.7% | 58.5% | 0.072 | |
| Smoker | 31.0% | 29.4% | 32.5% | 35.3% | <0.001 | |
| Prior history of stroke | 3.0% | 2.8% | 2.6% | 2.3% | 0.249 | |
| Dialysis | 13.0% | 12.3% | 14.7% | 15.0% | 0.003 | |
| Urgent admission | 17.4% | 20.4% | 22.1% | 20.8% | <0.001 | |
| Indication for hospitalization | ASR | 15.1% | 12.9% | 11.9% | 11.2% | <0.001 |
| AS | 84.9% | 87.1% | 88.1% | 88.8% | ||
| Body mass index | 18.5–29.9 | 85.1% | 85.5% | 84.4% | 84.1% | 0.002 |
| <18.5 | 10.2% | 11.2% | 11.7% | 12.5% | ||
| ≥30 | 4.7% | 3.2% | 3.9% | 3.4% | ||
| NYHA class | 0–2 | 40.8% | 39.9% | 37.5% | 39.5% | 0.146 |
| 3–4 | 20.1% | 20.0% | 20.5% | 19.4% | ||
| data NA | 39.1% | 40.1% | 42.0% | 41.1% | ||
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| Hospital volume | 1–35 | 41.8% | 39.3% | 37.5% | 39.8% | <0.001 |
| 36–68 | 33.5% | 32.5% | 32.7% | 27.3% | ||
| ≥69 | 24.8% | 28.2% | 29.9% | 33.0% | ||
| Number of patients undergoing surgery | 1,814 | 1,569 | 1,651 | 1,750 | <.001 | |
| (% to total patients) | 56.2% | 49.3% | 52.0% | 52.9% | ||
1st, 2nd, 3rd, and 4th quartiles of income (mean household income adjusted for regional price index): ≤2,799.5, 2,799.6–3,253.2, 3,253.3–3,719.1, ≥3,719.2 (1,000 yen); Hospital volume: the number of aortic valve surgery procedures performed during 2011 at each institution; p values were calculated using the chi-square test.
ASR, aortic stenosis and regurgitation; AS, aortic stenosis, BMI, body mass index; NYHA, New York Heart Association; NA, not available.
Process and outcome of surgical patients by municipality-level mean income strata.
| Municipality-level mean income (lowest to highest) | ||||||
| 1st | 2nd | 3rd | 4th |
| ||
| Combined surgery | CABG | 20.4% | 22.2% | 22.2% | 22.4% | 0.436 |
| TAA | 1.2% | 0.8% | 1.0% | 1.1% | 0.722 | |
| Maze | 6.5% | 6.9% | 6.5% | 8.9% | 0.018 | |
| Type of surgery | Plasty | 0.7% | 1.0% | 2.4% | 5.3% | <0.001 |
| AVR | 91.8% | 93.7% | 89.1% | 85.6% | ||
| DVR | 7.6% | 5.4% | 8.5% | 9.1% | ||
| Length of stay after surgery | 29 [22–41] | 28[22–41] | 27[21–39] | 26[19–37] | <0.001* | |
| Postoperative in-hospital death | 4.10% | 4.30% | 4.40% | 4.40% | 0.973 | |
p values were calculated using the chi-square test and *Kruskal-Wallis test.1st, 2nd, 3rd, and 4th quartiles of income (mean household income adjusted for regional price index): ≤2,799.5, 2,799.6–3,253.2, 3,253.3–3,719.1, ≥3,719.2 (1,000 yen); Length of stay is expressed as mean values [interquartile range].
CABG, coronary artery bypass graft; TAA, thoracic aortic aneurysm; AVR, aortic valve replacement; DVR, dual valve replacement.
Multivariate model of GEE for the likelihood of undergoing valve surgery.
| Unadjusted OR | 95% CI | Adjusted OR | 95% CI | ||||||
| Municipality-level mean income | 4 | 0.87 | 0.70 | - | 1.09 | 0.84 | 0.69 | - | 1.03 |
| 3 | 0.85 | 0.69 | - | 1.03 | 0.80 | 0.66 | - | 0.97 | |
| 2 | 0.76 | 0.63 | - | 0.91 | 0.72 | 0.60 | - | 0.86 | |
| 1 | 1 | 1 | |||||||
| Hospital volume | ≥69 | 3.78 | 2.96 | - | 4.82 | 3.36 | 2.67 | - | 4.24 |
| 36–68 | 3.39 | 2.81 | - | 4.08 | 3.24 | 2.68 | - | 3.91 | |
| 1–35 | 1 | 1 | |||||||
| Number of cardiac surgeons per 1 million population (per one increment) | 0.98 | 0.89 | - | 1.08 | 0.97 | 0.93 | - | 1.01 | |
| Age | ≥75 | 0.62 | 0.57 | - | 0.67 | 0.74 | 0.67 | - | 0.81 |
| Female | 0.82 | 0.77 | - | 0.88 | 1.02 | 0.94 | - | 1.11 | |
| Smoker | 1.23 | 1.12 | - | 1.34 | 1.13 | 1.02 | - | 1.26 | |
| NYHA class | Data NA | 1.05 | 0.91 | - | 1.21 | 1.17 | 1.01 | - | 1.35 |
| 4 | 0.72 | 0.56 | - | 0.91 | 1.52 | 1.22 | - | 1.91 | |
| 3 | 1.38 | 1.11 | - | 1.72 | 1.88 | 1.54 | - | 2.29 | |
| 2 | 1.53 | 1.27 | - | 1.84 | 1.63 | 1.38 | - | 1.92 | |
| 0–1 | 1 | 1 | |||||||
| Prior history of stroke | 0.95 | 0.74 | - | 1.23 | 1.09 | 0.85 | - | 1.39 | |
| Dialysis | 1.36 | 1.21 | - | 1.53 | 1.38 | 1.2 | - | 1.57 | |
| Urgent admission | 0.30 | 0.26 | - | 0.33 | 0.34 | 0.29 | - | 0.38 | |
| BMI | ≥30 | 1.02 | 0.85 | - | 1.22 | 0.95 | 0.78 | - | 1.16 |
| <18.5 | 0.74 | 0.66 | - | 0.83 | 0.78 | 0.69 | - | 0.88 | |
| 18.5–29.9 | 1 | 1 | |||||||
GEE, generalized estimating equation; Municipality-level mean income represents mean household income adjusted for regional price index. 1st 2nd, 3rd, and 4th quartiles of income: ≤2,799.5, 2,799.6–3,253.2, 3,253.3–3,719.1, ≥3,719.2 (1,000 yen); Hospital volume: the number of aortic valve surgery procedures performed during 2011 at each institution.
AS, aortic stenosis; BMI, body mass index; CI, confidence interval; NYHA: New York Heart Association; NA, not available; OR, odds ratio.
Multivariate model of GEE for postoperative in-hospital death among surgical patients.
| Unadjusted OR | 95% CI | Adjusted OR | 95% CI | ||||||
| Municipality-level mean income | 4 | 1.07 | 0.76 | - | 1.49 | 1.01 | 0.68 | - | 1.49 |
| 3 | 1.07 | 0.76 | - | 1.51 | 1.09 | 0.73 | - | 1.64 | |
| 2 | 1.03 | 0.74 | - | 1.45 | 1.15 | 0.77 | - | 1.71 | |
| 1 | 1 | 1 | |||||||
| Hospital volume | ≥69 | 0.58 | 0.42 | - | 0.80 | 0.51 | 0.35 | - | 0.73 |
| 36–68 | 0.66 | 0.49 | - | 0.87 | 0.66 | 0.47 | - | 0.92 | |
| 1–35 | 1 | 1 | |||||||
| Number of cardiac surgeons per one million population (per one increment) | 1.05 | 0.93 | - | 1.18 | 1.02 | 0.89 | - | 1.17 | |
| Age | ≥75 | 1.28 | 0.99 | - | 1.67 | 2.08 | 1.55 | - | 2.79 |
| Female | 0.88 | 0.69 | - | 1.12 | 1.44 | 1.02 | - | 2.03 | |
| Smoker | 1.14 | 0.89 | - | 1.45 | 1.21 | 0.89 | - | 1.63 | |
| NYHA class | Data NA | 1.99 | 1.30 | - | 3.04 | 1.77 | 1.11 | - | 2.81 |
| 4 | 4.52 | 2.76 | - | 7.41 | 2.76 | 1.51 | - | 5.04 | |
| 3 | 1.88 | 1.16 | - | 3.03 | 1.47 | 0.85 | - | 2.52 | |
| 2 | 0.81 | 0.50 | - | 1.30 | 0.88 | 0.53 | - | 1.47 | |
| 0–1 | 1 | 1 | |||||||
| Prior history of stroke | 1.94 | 1.11 | - | 3.37 | 2.17 | 1.14 | - | 4.13 | |
| Dialysis | 22.06 | 16.22 | - | 30.0 | 23.12 | 16.34 | - | 32.7 | |
| Urgent admission | 2.38 | 1.78 | - | 3.18 | 1.31 | 0.89 | - | 1.91 | |
| Length of stay after surgery (per one increment) | 1.01 | 1.01 | - | 1.01 | 1.00 | 1.00 | - | 1.01 | |
| BMI | ≥30 | 1.22 | 0.69 | - | 2.18 | 1.28 | 0.68 | - | 2.41 |
| <18.5 | 2 | 1.47 | - | 2.72 | 1.09 | 0.76 | - | 1.56 | |
| 18.5–29.9 | 1 | 1 | |||||||
| Combined surgery | CABG | 1.53 | 1.18 | - | 1.98 | 1.26 | 0.93 | - | 1.70 |
| TAA | 2.8 | 1.31 | - | 6.00 | 2.58 | 1.04 | - | 6.42 | |
| Maze | 1.18 | 0.75 | - | 1.86 | 1.01 | 0.60 | - | 1.71 | |
| Type of surgery | DVR | 0.91 | 0.51 | - | 1.62 | 0.81 | 0.42 | - | 1.55 |
| AVR | 0.43 | 0.26 | - | 0.69 | 0.43 | 0.24 | - | 0.79 | |
| Plasty | 1 | 1 | |||||||
GEE, generalized estimating equation; Income represents mean household income adjusted for regional price index. 1st, 2nd, 3rd, and 4th quartiles of income: ≤2,799.5, 2,799.6–3,253.2, 3,253.3–3,719.1, ≥3,719.2 (1,000 yen); Hospital volume: the number of aortic valve surgery procedures performed during 2011 at each institution;
OR, odds ratio; CI, confidence interval; AS, aortic stenosis; BMI, body mass index; NYHA, New York Heart Association; CABG, coronary artery bypass graft; TAA, thoracic aortic aneurysm; AVR, aortic valve replacement; DVR, dual valve replacement; NA, not available.