Literature DB >> 25347708

A catalyst selection protocol that identifies biomimetic motifs from β-hairpin libraries.

Masaomi Matsumoto1, Stephen J Lee, Marcey L Waters, Michel R Gagné.   

Abstract

Assaying a solid-phase library of histidine-containing β-hairpin peptides by a reactive tagging scheme in organic solvents selects for catalysts that reproduce the strategies used by His-based enzyme active sites to accelerate acyl- and phosphonyl-transfer reactions. Rate accelerations (k(rel)) in organic solvents of up to 2.4 × 10(8) are observed.

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Year:  2014        PMID： 25347708     DOI： 10.1021/ja503012g

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  6 in total

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Journal:  Int J Mol Sci       Date:  2021-02-05       Impact factor: 5.923

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Journal:  Chem Sci       Date:  2021-01-06       Impact factor: 9.825

4.  The role of β-hairpin conformation in ester hydrolysis peptide catalysts based on a TrpZip scaffold.

Authors:  Xinyu Liu; Riley Waters; Hannah E Gilbert; Gage T Barroso; Kelsey M Boyle; Leah S Witus
Journal:  RSC Adv       Date:  2021-07-06       Impact factor: 4.036

5.  Site-Selective Acylations with Tailor-Made Catalysts.

Authors:  Florian Huber; Stefan F Kirsch
Journal:  Chemistry       Date:  2016-03-10       Impact factor: 5.236

Review 6.  From supramolecular chemistry to the nucleosome: studies in biomolecular recognition.

Authors:  Marcey L Waters
Journal:  Beilstein J Org Chem       Date:  2016-08-17       Impact factor: 2.883
  6 in total

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