Literature DB >> 25332970

Placebo-driven clinical trials of yeast-derived β-(1-3) glucan in children with chronic respiratory problems.

Vaclav Vetvicka1, Josef Richter1, Vladimir Svozil1, Lucie Rajnohová Dobiášová1, Vlastimil Král1.   

Abstract

BACKGROUND: The role of glucan in stimulation of immune reactions has been studied for several decades. In this report we focused on the effects of orally administered glucan in children with chronic respiratory problems.
MATERIALS AND METHODS: We measured the levels of albumin, lysozyme and CRP in saliva of 40 children aged 8-12 years and evaluate the effects of 100 mg/d oral dose of glucan.
RESULTS: We found a significant increase in production of changes in production of lysozyme and CRP in glucan-treated children. In addition, a strong improvement in general conditions was found.
CONCLUSIONS: Short-term oral application of natural immunomodulator β-glucan stimulated mucosal immunity of children with chronic respiratory problems.

Entities:  

Keywords:  Glucan; children; lysozyme; mucosal immunity; saliva

Year:  2013        PMID: 25332970      PMCID: PMC4200675          DOI: 10.3978/j.issn.2305-5839.2013.07.01

Source DB:  PubMed          Journal:  Ann Transl Med        ISSN: 2305-5839


  27 in total

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Authors:  Vaclav Vetvicka; Jana Vetvickova
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9.  Elevated salivary C-reactive protein levels are associated with active and passive smoking in healthy youth: A pilot study.

Authors:  Rima Azar; Annie Richard
Journal:  J Inflamm (Lond)       Date:  2011-12-07       Impact factor: 4.981

Review 10.  The common cold: current therapy and natural history.

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  12 in total

1.  β-glucan affects mucosal immunity in children with chronic respiratory problems under physical stress: clinical trials.

Authors:  Josef Richter; Vladimir Svozil; Vlastimil Král; Lucie Rajnohová Dobiášová; Vaclav Vetvicka
Journal:  Ann Transl Med       Date:  2015-03

2.  Clinical trials of yeast-derived β-(1,3) glucan in children: effects on innate immunity.

Authors:  Josef Richter; Vladimir Svozil; Vlastimil Král; Lucie Rajnohová Dobiášová; Ivana Stiborová; Vaclav Vetvicka
Journal:  Ann Transl Med       Date:  2014-02

3.  Glucan supplementation enhances the immune response against an influenza challenge in mice.

Authors:  Vaclav Vetvicka; Jana Vetvickova
Journal:  Ann Transl Med       Date:  2015-02

4.  Effect of Immune-Enhancing Enteral Nutrition Enriched with or without Beta-Glucan on Immunomodulation in Critically Ill Patients.

Authors:  Jae Gil Lee; Young Sam Kim; Young Ju Lee; Hyeon Yeong Ahn; Minjoo Kim; Minkyung Kim; Min Jung Cho; Younsoo Cho; Jong Ho Lee
Journal:  Nutrients       Date:  2016-06-02       Impact factor: 5.717

Review 5.  Clinical and Physiological Perspectives of β-Glucans: The Past, Present, and Future.

Authors:  Khawaja Muhammad Imran Bashir; Jae-Suk Choi
Journal:  Int J Mol Sci       Date:  2017-09-05       Impact factor: 5.923

Review 6.  Optimizing Tumor Microenvironment for Cancer Immunotherapy: β-Glucan-Based Nanoparticles.

Authors:  Mei Zhang; Julian A Kim; Alex Yee-Chen Huang
Journal:  Front Immunol       Date:  2018-02-26       Impact factor: 7.561

Review 7.  Respiratory Tract Infections and the Role of Biologically Active Polysaccharides in Their Management and Prevention.

Authors:  Milos Jesenak; Ingrid Urbancikova; Peter Banovcin
Journal:  Nutrients       Date:  2017-07-20       Impact factor: 5.717

Review 8.  β-glucans and cholesterol (Review).

Authors:  Petr Sima; Luca Vannucci; Vaclav Vetvicka
Journal:  Int J Mol Med       Date:  2018-01-22       Impact factor: 4.101

9.  Ingestion of Exopolymers from Aureobasidium pullulans Reduces the Duration of Cold and Flu Symptoms: A Randomized, Placebo-Controlled Intervention Study.

Authors:  Jong-Min Lim; Eunju Do; Dong-Chan Park; Go-Woon Jung; Hyung-Rae Cho; Seo-Young Lee; Jae Wook Shin; Kyung Min Baek; Jae-Suk Choi
Journal:  Evid Based Complement Alternat Med       Date:  2018-05-30       Impact factor: 2.629

Review 10.  β-1,3/1,6-Glucans and Immunity: State of the Art and Future Directions.

Authors:  Elena De Marco Castro; Philip C Calder; Helen M Roche
Journal:  Mol Nutr Food Res       Date:  2020-04-27       Impact factor: 5.914

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