BACKGROUND: The strong immunostimulating potential of β-glucans has been well established in numerous diseases. However, the effects on viral infection were less studied. METHODS: In our study, we focused on possible effects of a special combined glucan formulation on immunosuppression caused by influenza infection. RESULTS: We found that a 2-week oral feeding with glucan mixture significantly reduced the effects of influenza infection in total mortality. Our study was focused on phagocytosis, cytokine levels, antibody response and cytotoxicity assay. CONCLUSIONS: Based on our data, we concluded that these effects are caused by stimulation of both cellular and humoral immune reaction resulting in lower viral load.
BACKGROUND: The strong immunostimulating potential of β-glucans has been well established in numerous diseases. However, the effects on viral infection were less studied. METHODS: In our study, we focused on possible effects of a special combined glucan formulation on immunosuppression caused by influenza infection. RESULTS: We found that a 2-week oral feeding with glucan mixture significantly reduced the effects of influenza infection in total mortality. Our study was focused on phagocytosis, cytokine levels, antibody response and cytotoxicity assay. CONCLUSIONS: Based on our data, we concluded that these effects are caused by stimulation of both cellular and humoral immune reaction resulting in lower viral load.
Authors: Zhiyuan Wen; Ling Ye; Yulong Gao; Lei Pan; Ke Dong; Zhigao Bu; Richard W Compans; Chinglai Yang Journal: Antiviral Res Date: 2009-09-20 Impact factor: 5.970
Authors: Milos Jesenak; Juraj Majtan; Zuzana Rennerova; Jan Kyselovic; Peter Banovcin; Martin Hrubisko Journal: Int Immunopharmacol Date: 2012-12-20 Impact factor: 4.932
Authors: Ingrid Urbancikova; Dana Hudackova; Juraj Majtan; Zuzana Rennerova; Peter Banovcin; Milos Jesenak Journal: Evid Based Complement Alternat Med Date: 2020-04-13 Impact factor: 2.629
Authors: Allison M Owen; Jessica B Fults; Naeem K Patil; Antonio Hernandez; Julia K Bohannon Journal: Front Immunol Date: 2021-02-18 Impact factor: 7.561