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Literature DB >> 25330976

PET imaging of bacterial infections with fluorine-18-labeled maltohexaose.

Xinghai Ning¹, Wonewoo Seo², Seungjun Lee¹, Kiyoko Takemiya³, Mohammad Rafi¹, Xuli Feng¹, Daiana Weiss³, Xiaojian Wang¹, Larry Williams², Vernon M Camp², Malveaux Eugene², W Robert Taylor⁴, Mark Goodman², Niren Murthy¹.

Abstract

A positron emission tomography (PET) tracer composed of (18)F-labeled maltohexaose (MH(18)F) can image bacteria in vivo with a sensitivity and specificity that are orders of magnitude higher than those of fluorodeoxyglucose ((18)FDG). MH(18)F can detect early-stage infections composed of as few as 10(5) E. coli colony-forming units (CFUs), and can identify drug resistance in bacteria in vivo. MH(18)F has the potential to improve the diagnosis of bacterial infections given its unique combination of high specificity and sensitivity for bacteria.

Entities: Chemical Disease Gene Species

Keywords: bacterial infections; maltodextrin transporters; maltohexaose; positron emission tomography; radiochemistry

Mesh：

Substances：

Year: 2014 PMID： 25330976 PMCID： PMC4430476 DOI： 10.1002/anie.201408533

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

61 in total

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2. The use of 18F-FDG-PET/CT in the diagnostic workup of CIED infections: another perspective.

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Authors: Devaki Shilpa Surasi; Pradeep Bhambhvani; Jon A Baldwin; Samuel E Almodovar; Janis P O'Malley
Journal: J Nucl Med Technol Date: 2014-02-06

4. Imaging bacterial infections with radiolabeled 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil.

Authors: Chetan Bettegowda; Catherine A Foss; Ian Cheong; Yuchuan Wang; Luis Diaz; Nishant Agrawal; James Fox; James Dick; Long H Dang; Shibin Zhou; Kenneth W Kinzler; Bert Vogelstein; Martin G Pomper
Journal: Proc Natl Acad Sci U S A Date: 2005-01-14 Impact factor: 11.205

5. Arylfluoroborates and alkylfluorosilicates as potential PET imaging agents: high-yielding aqueous biomolecular 18F-labeling.

Authors: Richard Ting; Michael J Adam; Thomas J Ruth; David M Perrin
Journal: J Am Chem Soc Date: 2005-09-28 Impact factor: 15.419

6. Uses and limitations of FDG positron emission tomography in patients with head and neck cancer.

Authors: M M Hanasono; L D Kunda; G M Segall; G H Ku; D J Terris
Journal: Laryngoscope Date: 1999-06 Impact factor: 3.325

Review 7. Advantages and limitations of FDG PET in the follow-up of breast cancer.

Authors: Peter Lind; Isabel Igerc; Thomas Beyer; Peter Reinprecht; Klaus Hausegger
Journal: Eur J Nucl Med Mol Imaging Date: 2004-04-15 Impact factor: 9.236

Review 8. FDG-PET/CT in infections: the imaging method of choice?

Authors: Andor W J M Glaudemans; Alberto Signore
Journal: Eur J Nucl Med Mol Imaging Date: 2010-10 Impact factor: 9.236

9. Investigations of a (99m)Tc-labeled bacteriophage as a potential infection-specific imaging agent.

Authors: Mary Rusckowski; Suresh Gupta; Guozheng Liu; Shuping Dou; Donald J Hnatowich
Journal: J Nucl Med Date: 2004-07 Impact factor: 10.057

10. A new nucleophilic fluorine-18 labeling method for aliphatic mesylates: reaction in ionic liquids shows tolerance for water.

Authors: Dong Wook Kim; Yearn Seong Choe; Dae Yoon Chi
Journal: Nucl Med Biol Date: 2003-05 Impact factor: 2.408

36 in total

1. A novel synthesis of 6''-[¹⁸ F]-fluoromaltotriose as a PET tracer for imaging bacterial infection.

Authors: Mohammad Namavari; Gayatri Gowrishankar; Ananth Srinivasan; Sanjiv S Gambhir; Thomas Haywood; Corinne Beinat
Journal: J Labelled Comp Radiopharm Date: 2018-03-30 Impact factor: 1.921

2. A Systematic Approach for Developing Bacteria-Specific Imaging Tracers.

Authors: Alvaro A Ordonez; Edward A Weinstein; Lauren E Bambarger; Vikram Saini; Yong S Chang; Vincent P DeMarco; Mariah H Klunk; Michael E Urbanowski; Kimberly L Moulton; Allison M Murawski; Supriya Pokkali; Alvin S Kalinda; Sanjay K Jain
Journal: J Nucl Med Date: 2016-09-15 Impact factor: 10.057

Review 3. Molecular imaging of bacterial infections: Overcoming the barriers to clinical translation.

Authors: Alvaro A Ordonez; Mark A Sellmyer; Gayatri Gowrishankar; Camilo A Ruiz-Bedoya; Elizabeth W Tucker; Christopher J Palestro; Dima A Hammoud; Sanjay K Jain
Journal: Sci Transl Med Date: 2019-09-04 Impact factor: 17.956

4. Specific Imaging of Bacterial Infection Using 6″-¹⁸F-Fluoromaltotriose: A Second-Generation PET Tracer Targeting the Maltodextrin Transporter in Bacteria.

Authors: Gayatri Gowrishankar; Jonathan Hardy; Mirwais Wardak; Mohammad Namavari; Robert E Reeves; Evgenios Neofytou; Ananth Srinivasan; Joseph C Wu; Christopher H Contag; Sanjiv Sam Gambhir
Journal: J Nucl Med Date: 2017-05-10 Impact factor: 10.057

5. ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo.

Authors: Anna-Maria Rolle; Mike Hasenberg; Christopher R Thornton; Djamschid Solouk-Saran; Linda Männ; Juliane Weski; Andreas Maurer; Eliane Fischer; Philipp R Spycher; Roger Schibli; Frederic Boschetti; Sabine Stegemann-Koniszewski; Dunja Bruder; Gregory W Severin; Stella E Autenrieth; Sven Krappmann; Genna Davies; Bernd J Pichler; Matthias Gunzer; Stefan Wiehr
Journal: Proc Natl Acad Sci U S A Date: 2016-01-19 Impact factor: 11.205

6. A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo.

Authors: Xiaojian Wang; Clarissa A Borges; Xinghai Ning; Mohammad Rafi; Jingtuo Zhang; Bora Park; Kiyoko Takemiya; Carlo Lo Sterzo; W Robert Taylor; Lee Riley; Niren Murthy
Journal: Bioconjug Chem Date: 2018-04-25 Impact factor: 4.774

Review 7. Small Molecule Sensors Targeting the Bacterial Cell Wall.

Authors: Matthew F L Parker; Robert R Flavell; Justin M Luu; Oren S Rosenberg; Michael A Ohliger; David M Wilson
Journal: ACS Infect Dis Date: 2020-06-09 Impact factor: 5.084

8. Deoxyfluoro-d-trehalose (FDTre) analogues as potential PET probes for imaging mycobacterial infection.

Authors: Sarah R Rundell; Zachary L Wagar; Lisa M Meints; Claire D Olson; Mara K O'Neill; Brent F Piligian; Anne W Poston; Robin J Hood; Peter J Woodruff; Benjamin M Swarts
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Review 9. Pathogen-Specific Bacterial Imaging in Nuclear Medicine.

Authors: Alvaro A Ordonez; Sanjay K Jain
Journal: Semin Nucl Med Date: 2017-12-14 Impact factor: 4.446

10. Positron Emission Tomography Imaging of Staphylococcus aureus Infection Using a Nitro-Prodrug Analogue of 2-[¹⁸F]F-p-Aminobenzoic Acid.

Authors: Yong Li; Fereidoon Daryaee; Grace E Yoon; Doyoung Noh; Peter M Smith-Jones; Yuanyuan Si; Stephen G Walker; Nashaat Turkman; Labros Meimetis; Peter J Tonge
Journal: ACS Infect Dis Date: 2020-07-31 Impact factor: 5.084