Literature DB >> 2532362

Cloning of the cDNA and gene for a human D2 dopamine receptor.

D K Grandy1, M A Marchionni, H Makam, R E Stofko, M Alfano, L Frothingham, J B Fischer, K J Burke-Howie, J R Bunzow, A C Server.   

Abstract

A clone encoding a human D2 dopamine receptor was isolated from a pituitary cDNA library and sequenced. The deduced protein sequence is 96% identical with that of the cloned rat receptor with one major difference: the human receptor contains an additional 29 amino acids in its putative third cytoplasmic loop. Southern blotting demonstrated the presence of only one human D2 receptor gene. Two overlapping phage containing the gene were isolated and characterized. DNA sequence analysis of these clones showed that the coding sequence is interrupted by six introns and that the additional amino acids present in the human pituitary receptor are encoded by a single exon of 87 base pairs. The involvement of this sequence in alternative splicing and its biological significance are discussed.

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Year:  1989        PMID： 2532362      PMCID： PMC298581          DOI： 10.1073/pnas.86.24.9762

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

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  75 in total

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Review 5.  Dopamine receptor genes: new tools for molecular psychiatry.

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