| Literature DB >> 25319790 |
Jérémie Lemarié1, Damien Barraud, Sébastien Gibot.
Abstract
The diagnosis of sepsis, and especially its differentiation from sterile inflammation, may be challenging. TREM-1, the triggering receptor expressed on myeloid cells-1, is an amplifier of the innate immune response. Its soluble form acts as a decoy for the natural TREM-1 ligand and dampens its activation. In this chapter, we review the numerous studies that have evaluated the usefulness of sTREM-1 concentration determination for the diagnosis and the prognosis evaluation of sepsis or localized infection. Nowadays, sandwich ELISA kits are available and the assay is described.Entities:
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Year: 2015 PMID： 25319790 DOI： 10.1007/978-1-4939-1776-1_17
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745