Zu-Qin Yang1, Jing-Yun Mai2, Min-Li Zhu2, Xiu-Man Xiao2, Xiao-Xiao He2, Shang-Qin Chen2, Zhen-Lang Lin2, Xing Feng1. 1. Department of Neonatology, Children's Hospital of Soochow University, Suzhou, 215025, Jiangsu, People's Republic of China. 2. Department of Neonatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, People's Republic of China.
Abstract
BACKGROUND: Neonatal ventilator-associated pneumonia (NVAP) is one of the main infections acquired in hospitals, and soluble triggering receptors expressed on myeloid cells-1 (sTREM-1) are a TREM-1 subtype that can be released into the blood or bodily fluids during an infection. METHODS: The patients included in the present study were divided into three groups: the NVAP group, the first control group, and the second control group (n = 20, each). Children requiring respiratory treatment were assigned to the NVAP group, newborns who received mechanical ventilation and had neonatal respiratory distress syndrome were assigned to the first control group, and newborns with normal X-ray and electrocardiogram results but no non-pulmonary infection was assigned to the second control group. The blood and bronchoalveolar lavage fluid (BALF) sTREM-1 levels in all newborns were analyzed. RESULTS: The acute-phase blood and BALF sTREM-1 levels were significantly higher in the NVAP group than in the first control group, and the blood sTREM-1 expression level was lower in the second control group than in the NVAP group. CONCLUSION: The present results suggest that sTREM-1 might be a useful biomarker for NVAP prediction in the Department of Pediatrics.
BACKGROUND: Neonatal ventilator-associated pneumonia (NVAP) is one of the main infections acquired in hospitals, and soluble triggering receptors expressed on myeloid cells-1 (sTREM-1) are a TREM-1 subtype that can be released into the blood or bodily fluids during an infection. METHODS: The patients included in the present study were divided into three groups: the NVAP group, the first control group, and the second control group (n = 20, each). Children requiring respiratory treatment were assigned to the NVAP group, newborns who received mechanical ventilation and had neonatal respiratory distress syndrome were assigned to the first control group, and newborns with normal X-ray and electrocardiogram results but no non-pulmonary infection was assigned to the second control group. The blood and bronchoalveolar lavage fluid (BALF) sTREM-1 levels in all newborns were analyzed. RESULTS: The acute-phase blood and BALF sTREM-1 levels were significantly higher in the NVAP group than in the first control group, and the blood sTREM-1 expression level was lower in the second control group than in the NVAP group. CONCLUSION: The present results suggest that sTREM-1 might be a useful biomarker for NVAP prediction in the Department of Pediatrics.
Authors: Víctor Arízaga-Ballesteros; Mario René Alcorta-García; Lizzeth Carolina Lázaro-Martínez; Jesús Manuel Amézquita-Gómez; José Manuel Alanís-Cajero; Luis Villela; Fabiola Castorena-Torres; Víctor Javier Lara-Díaz Journal: Int J Infect Dis Date: 2014-11-05 Impact factor: 3.623
Authors: Sarah A Horst; Anna Linnér; Andreas Beineke; Sabine Lehne; Claudia Höltje; Alexander Hecht; Anna Norrby-Teglund; Eva Medina; Oliver Goldmann Journal: J Innate Immun Date: 2013-04-04 Impact factor: 7.349
Authors: Seham F A Azab; Hanan S Sherbiny; Safaa H Saleh; Wafaa F Elsaeed; Mona M Elshafiey; Ahmed G Siam; Mohamed A Arafa; Ashgan A Alghobashy; Eman A Bendary; Maha A A Basset; Sanaa M Ismail; Nagwa E Akeel; Nahla A Elsamad; Wesam A Mokhtar; Tarek Gheith Journal: BMC Infect Dis Date: 2015-08-06 Impact factor: 3.090