Literature DB >> 25315963

Oxidative stress-related genetic variants, pro- and antioxidant intake and status, and advanced prostate cancer risk.

Milan S Geybels1, Piet A van den Brandt2, Frederik J van Schooten3, Bas A J Verhage2.   

Abstract

BACKGROUND: Increased oxidative stress has been linked to prostate cancer. We investigated oxidative stress-related genetic variants in relation to advanced prostate cancer risk and examined potential interactions with pro- and antioxidant exposures.
METHODS: A case-cohort analysis was conducted in the prospective Netherlands Cohort Study, which included 58,279 men ages 55 to 69 years. Cohort members completed a baseline questionnaire and provided toenail clippings, which were used to isolate DNA. Advanced prostate cancer cases were identified during 17.3 years of follow-up. The analysis included 14 genetic variants and 11 exposures. Cox regression models were used for analysis and FDR Q-values were calculated.
RESULTS: Complete genotyping data were available for 952 cases and 1,798 subcohort members. CAT rs1001179 was associated with stage III/IV and stage IV prostate cancer risk, with HRs per minor allele of 1.16 [95% confidence intervals (CI), 1.01-1.33; P = 0.032] and 1.25 (95% CI, 1.07-1.46; P = 0.006), respectively. We tested 151 gene-environment interactions in relation to both stage III/IV and IV prostate cancer risk. Seven interactions were statistically significant after adjusting for multiple testing (FDR Q-value <0.20); for stage III/IV prostate cancer, these involved intake of β-carotene (GPX1 rs17650792, hOGG1 rs1052133) and heme iron (GPX1 rs1800668 and rs3448), and for stage IV prostate cancer, these involved intake of catechin (SOD2 rs4880) and heme iron (hOGG1 rs1052133, SOD1 rs10432782).
CONCLUSION: This study of advanced prostate cancer risk showed a marginal association with a CAT polymorphism and seven novel gene-environment interactions in the oxidative stress pathway. IMPACT: Oxidative stress-related genes and exposures may have a joint effect on advanced prostate cancer. Cancer Epidemiol Biomarkers Prev; 24(1); 178-86. ©2014 AACR. ©2014 American Association for Cancer Research.

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Year:  2014        PMID： 25315963     DOI： 10.1158/1055-9965.EPI-14-0968

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  15 in total

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2.  Selenium- or Vitamin E-Related Gene Variants, Interaction with Supplementation, and Risk of High-Grade Prostate Cancer in SELECT.

Authors:  Philip W Kantoff; Lorelei A Mucci; June M Chan; Amy K Darke; Kathryn L Penney; Catherine M Tangen; Phyllis J Goodman; Gwo-Shu Mary Lee; Tong Sun; Sam Peisch; Alex M Tinianow; James M Rae; Eric A Klein; Ian M Thompson
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2016-05-06       Impact factor: 4.254

3.  The Role of Catalase C262T Gene Polymorphism in the Susceptibility and Survival of Cancers.

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4.  Genetic Variation in the Human SORBS1 Gene is Associated With Blood Pressure Regulation and Age at Onset of Hypertension: A SAPPHIRe Cohort Study.

Authors:  Tien-Jyun Chang; Wen-Chang Wang; Chao A Hsiung; Chih-Tsueng He; Ming-Wei Lin; Wayne Huey-Herng Sheu; Yi-Cheng Chang; Tom Quertermous; Ida Chen; Jerome Rotter; Lee-Ming Chuang
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6.  Association of rs1800668 polymorphism in glutathione peroxidase- 1 gene and risk of rheumatoid arthritis in Pakistani population.

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Journal:  Pak J Med Sci       Date:  2016 Sep-Oct       Impact factor: 1.088

7.  Interactions between dietary acrylamide intake and genes for ovarian cancer risk.

Authors:  Janneke G F Hogervorst; Piet A van den Brandt; Roger W L Godschalk; Frederik-Jan van Schooten; Leo J Schouten
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8.  The influence of single nucleotide polymorphisms on the association between dietary acrylamide intake and endometrial cancer risk.

Authors:  Janneke G F Hogervorst; Piet A van den Brandt; Roger W L Godschalk; Frederik-Jan van Schooten; Leo J Schouten
Journal:  Sci Rep       Date:  2016-10-07       Impact factor: 4.379

9.  Two common functional catalase gene polymorphisms (rs1001179 and rs794316) and cancer susceptibility: evidence from 14,942 cancer cases and 43,285 controls.

Authors:  Kang Liu; Xinghan Liu; Meng Wang; Xijing Wang; Huafeng Kang; Shuai Lin; Pengtao Yang; Cong Dai; Peng Xu; Shanli Li; Zhijun Dai
Journal:  Oncotarget       Date:  2016-09-27

10.  Antioxidant defence-related genetic variants are not associated with higher risk of secondary thyroid cancer after treatment of malignancy in childhood or adolescence.

Authors:  Ana Lina Vodusek; Katja Goricar; Barbara Gazic; Vita Dolzan; Janez Jazbec
Journal:  Radiol Oncol       Date:  2016-02-16       Impact factor: 2.991
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