Literature DB >> 27197287

Selenium- or Vitamin E-Related Gene Variants, Interaction with Supplementation, and Risk of High-Grade Prostate Cancer in SELECT.

Philip W Kantoff1,2, Lorelei A Mucci3,4, June M Chan5, Amy K Darke6, Kathryn L Penney3,4, Catherine M Tangen6, Phyllis J Goodman6, Gwo-Shu Mary Lee1, Tong Sun1, Sam Peisch4, Alex M Tinianow3, James M Rae7, Eric A Klein8, Ian M Thompson9.   

Abstract

BACKGROUND: Epidemiologic studies and secondary analyses of randomized trials supported the hypothesis that selenium and vitamin E lower prostate cancer risk. However, the Selenium and Vitamin E Cancer Prevention Trial (SELECT) showed no benefit of either supplement. Genetic variants involved in selenium or vitamin E metabolism or transport may underlie the complex associations of selenium and vitamin E.
METHODS: We undertook a case-cohort study of SELECT participants randomized to placebo, selenium, or vitamin E. The subcohort included 1,434 men; our primary outcome was high-grade prostate cancer (N = 278 cases, Gleason 7 or higher cancer). We used weighted Cox regression to examine the association between SNPs and high-grade prostate cancer risk. To assess effect modification, we created interaction terms between randomization arm and genotype and calculated log likelihood statistics.
RESULTS: We noted statistically significant (P < 0.05) interactions between selenium assignment, SNPs in CAT, SOD2, PRDX6, SOD3, and TXNRD2, and high-grade prostate cancer risk. Statistically significant SNPs that modified the association of vitamin E assignment and high-grade prostate cancer included SEC14L2, SOD1, and TTPA In the placebo arm, several SNPs, hypothesized to interact with supplement assignment and risk of high-grade prostate cancer, were also directly associated with outcome.
CONCLUSION: Variants in selenium and vitamin E metabolism/transport genes may influence risk of overall and high-grade prostate cancer, and may modify an individual man's response to vitamin E or selenium supplementation with regards to these risks. IMPACT: The effect of selenium or vitamin E supplementation on high-grade prostate cancer risk may vary by genotype. Cancer Epidemiol Biomarkers Prev; 25(7); 1050-8. ©2016 AACR. ©2016 American Association for Cancer Research.

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Year:  2016        PMID： 27197287      PMCID： PMC5086806          DOI： 10.1158/1055-9965.EPI-16-0104

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  60 in total

Review 1.  Polymorphisms in DNA repair genes and associations with cancer risk.

Authors:  Ellen L Goode; Cornelia M Ulrich; John D Potter
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2002-12       Impact factor: 4.254

2.  Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro.

Authors:  Ramesh Ummanni; Frederico Barreto; Simone Venz; Christian Scharf; Christine Barett; Heiko A Mannsperger; Jan Christoph Brase; Ruprecht Kuner; Thorsten Schlomm; Guido Sauter; Holger Sültmann; Ulrike Korf; Carsten Bokemeyer; Reinhard Walther; Tim H Brümmendorf; Stefan Balabanov
Journal:  J Proteome Res       Date:  2012-03-28       Impact factor: 4.466

3.  Variation in selenoenzyme genes and prostate cancer risk and survival.

Authors:  Milan S Geybels; Carolyn M Hutter; Erika M Kwon; Elaine A Ostrander; Rong Fu; Ziding Feng; Janet L Stanford; Ulrike Peters
Journal:  Prostate       Date:  2012-11-09       Impact factor: 4.104

4.  Analysis of differentially expressed genes in LNCaP prostate cancer progression model.

Authors:  Bang-Xiang Xie; Hui Zhang; Jian Wang; Bo Pang; Rui-Qin Wu; Xiao-Long Qian; Lan Yu; Shan-Hu Li; Qing-Guo Shi; Cui-Fen Huang; Jian-Guang Zhou
Journal:  J Androl       Date:  2010-09-23

5.  Manganese superoxide dismutase polymorphism, prediagnostic antioxidant status, and risk of clinical significant prostate cancer.

Authors:  Haojie Li; Philip W Kantoff; Edward Giovannucci; Michael F Leitzmann; J Michael Gaziano; Meir J Stampfer; Jing Ma
Journal:  Cancer Res       Date:  2005-03-15       Impact factor: 12.701

6.  Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer.

Authors:  K Yoshizawa; W C Willett; S J Morris; M J Stampfer; D Spiegelman; E B Rimm; E Giovannucci
Journal:  J Natl Cancer Inst       Date:  1998-08-19       Impact factor: 13.506

7.  Different association of manganese superoxide dismutase gene polymorphisms with risk of prostate, esophageal, and lung cancers: evidence from a meta-analysis of 20,025 subjects.

Authors:  Guo-Gui Sun; Ya-Di Wang; Yi-Fang Lu; Wan-Ning Hu
Journal:  Asian Pac J Cancer Prev       Date:  2013

8.  Peroxiredoxin 1 interacts with androgen receptor and enhances its transactivation.

Authors:  Soo-Yeon Park; Xiaofei Yu; Clement Ip; James L Mohler; Paul N Bogner; Young-Mee Park
Journal:  Cancer Res       Date:  2007-10-01       Impact factor: 12.701

9.  Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial.

Authors:  L C Clark; B Dalkin; A Krongrad; G F Combs; B W Turnbull; E H Slate; R Witherington; J H Herlong; E Janosko; D Carpenter; C Borosso; S Falk; J Rounder
Journal:  Br J Urol       Date:  1998-05

10.  Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress.

Authors:  H C Whitaker; D Patel; W J Howat; A Y Warren; J D Kay; T Sangan; J C Marioni; J Mitchell; S Aldridge; H J Luxton; C Massie; A G Lynch; D E Neal
Journal:  Br J Cancer       Date:  2013-07-23       Impact factor: 7.640
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  14 in total

1.  Pharmacogenomics and Placebo Response in a Randomized Clinical Trial in Asthma.

Authors:  Rui-Sheng Wang; Damien C Croteau-Chonka; Edwin K Silverman; J Loscalzo; Scott T Weiss; Kathryn T Hall
Journal:  Clin Pharmacol Ther       Date:  2019-10-28       Impact factor: 6.875

Review 2.  Vitamin E and cancer prevention: Studies with different forms of tocopherols and tocotrienols.

Authors:  Chung S Yang; Philip Luo; Zishuo Zeng; Hong Wang; Mokenge Malafa; Nanjoo Suh
Journal:  Mol Carcinog       Date:  2020-02-03       Impact factor: 4.784

Review 3.  Extracellular superoxide dismutase and its role in cancer.

Authors:  Brandon Griess; Eric Tom; Frederick Domann; Melissa Teoh-Fitzgerald
Journal:  Free Radic Biol Med       Date:  2017-08-24       Impact factor: 7.376

4.  [EEFSEC knockdown inhibits proliferation, migration and invasion of prostate cancer cells in vitro].

Authors:  B Xu; J Hao; Q Xie; N Sa; S Wang; X DU; H Lu; P Gao; G Shi; X Dong
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2021-12-20

5.  In Vitro Activity of Ebselen and Diphenyl Diselenide Alone and in Combination with Drugs against Trichophyton mentagrophytes Strains.

Authors:  Sebastian Gnat; Dominik Łagowski; Mariusz Dyląg; Grzegorz Jóźwiak; Aleksandra Trościańczyk; Aneta Nowakiewicz
Journal:  Pharmaceutics       Date:  2022-05-28       Impact factor: 6.525

6.  Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos.

Authors:  Meng Gao; Jun Hu; Yuejie Zhu; Xianqing Wang; Shumin Zeng; Yijiang Hong; Guang Zhao
Journal:  Int J Mol Sci       Date:  2022-04-26       Impact factor: 6.208

Review 7.  Non-alcoholic fatty liver disease in 2016.

Authors:  S A Townsend; Philip N Newsome
Journal:  Br Med Bull       Date:  2016-08-19       Impact factor: 4.291

8.  Protective Effects of Selenium Nanoparticle-Enriched Lactococcus lactis NZ9000 against Enterotoxigenic Escherichia coli K88-Induced Intestinal Barrier Damage in Mice.

Authors:  Yue Chen; Lei Qiao; Xiaofan Song; Li Ma; Xina Dou; Chunlan Xu
Journal:  Appl Environ Microbiol       Date:  2021-09-15       Impact factor: 4.792

Review 9.  A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species-A Critical Review.

Authors:  Bozena Hosnedlova; Marta Kepinska; Sylvie Skalickova; Carlos Fernandez; Branislav Ruttkay-Nedecky; Thembinkosi Donald Malevu; Jiri Sochor; Mojmir Baron; Magdalena Melcova; Jarmila Zidkova; Rene Kizek
Journal:  Int J Mol Sci       Date:  2017-10-21       Impact factor: 5.923

Review 10.  Selenium and selenoproteins: it's role in regulation of inflammation.

Authors:  Sneha Hariharan; Selvakumar Dharmaraj
Journal:  Inflammopharmacology       Date:  2020-03-06       Impact factor: 4.473
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