Geoffrey C Kabat1, Mimi Y Kim, Albert R Hollenbeck, Thomas E Rohan. 1. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA, geoffrey.kabat@einstein.yu.edu.
Abstract
PURPOSE: To examine the association of adult height with risk of cancer at different anatomic sites in a cohort of men and women. METHODS: The association of self-reported height with subsequent cancer risk was assessed in 288,683 men and 192,514 women enrolled in the National Institutes of Health-AARP Diet and Health Study. After a median follow-up of 10.5 years, incident cancer was diagnosed in 51,139 men and 23,407 women. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (95 % CIs) for the association of height with cancer risk. RESULTS: After adjustment for covariates, height was positively associated with increased risk of all cancers combined in both men [HR10 cm increase = 1.05 (95 % CI 1.04-1.06)] and women [HR10 cm increase = 1.08 (95 % CI 1.06-1.10)]. Several sites common to men and women showed significant positive associations with height: colon, rectum, kidney, melanoma, and non-Hodgkin's lymphoma. For other shared sites, the association differed by sex. For still other sites, there was no clear association with height. Positive associations were also observed with cancers of the breast, endometrium, and prostate. CONCLUSIONS: Different patterns were observed in the height-cancer association by sex. Studies investigating the biological mechanisms underlying the association of height with cancer risk should focus on those sites that show a reproducible association with attained height.
PURPOSE: To examine the association of adult height with risk of cancer at different anatomic sites in a cohort of men and women. METHODS: The association of self-reported height with subsequent cancer risk was assessed in 288,683 men and 192,514 women enrolled in the National Institutes of Health-AARP Diet and Health Study. After a median follow-up of 10.5 years, incident cancer was diagnosed in 51,139 men and 23,407 women. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (95 % CIs) for the association of height with cancer risk. RESULTS: After adjustment for covariates, height was positively associated with increased risk of all cancers combined in both men [HR10 cm increase = 1.05 (95 % CI 1.04-1.06)] and women [HR10 cm increase = 1.08 (95 % CI 1.06-1.10)]. Several sites common to men and women showed significant positive associations with height: colon, rectum, kidney, melanoma, and non-Hodgkin's lymphoma. For other shared sites, the association differed by sex. For still other sites, there was no clear association with height. Positive associations were also observed with cancers of the breast, endometrium, and prostate. CONCLUSIONS: Different patterns were observed in the height-cancer association by sex. Studies investigating the biological mechanisms underlying the association of height with cancer risk should focus on those sites that show a reproducible association with attained height.
Authors: Cari M Kitahara; Marjorie L McCullough; Silvia Franceschi; Sabina Rinaldi; Alicja Wolk; Gila Neta; Hans Olov Adami; Kristin Anderson; Gabriella Andreotti; Laura E Beane Freeman; Leslie Bernstein; Julie E Buring; Francoise Clavel-Chapelon; Lisa A De Roo; Yu-Tang Gao; J Michael Gaziano; Graham G Giles; Niclas Håkansson; Pamela L Horn-Ross; Vicki A Kirsh; Martha S Linet; Robert J MacInnis; Nicola Orsini; Yikyung Park; Alpa V Patel; Mark P Purdue; Elio Riboli; Kimberly Robien; Thomas Rohan; Dale P Sandler; Catherine Schairer; Arthur B Schneider; Howard D Sesso; Xiao-Ou Shu; Pramil N Singh; Piet A van den Brandt; Elizabeth Ward; Elisabete Weiderpass; Emily White; Yong-Bing Xiang; Anne Zeleniuch-Jacquotte; Wei Zheng; Patricia Hartge; Amy Berrington de González Journal: Thyroid Date: 2016-02 Impact factor: 6.568
Authors: Albina N Minlikeeva; Kirsten B Moysich; Paul C Mayor; John L Etter; Rikki A Cannioto; Roberta B Ness; Kristen Starbuck; Robert P Edwards; Brahm H Segal; Sashikant Lele; Kunle Odunsi; Brenda Diergaarde; Francesmary Modugno Journal: Cancer Causes Control Date: 2018-01-11 Impact factor: 2.506
Authors: Ben Zhang; Xiao-Ou Shu; Ryan J Delahanty; Chenjie Zeng; Kyriaki Michailidou; Manjeet K Bolla; Qin Wang; Joe Dennis; Wanqing Wen; Jirong Long; Chun Li; Alison M Dunning; Jenny Chang-Claude; Mitul Shah; Barbara J Perkins; Kamila Czene; Hatef Darabi; Mikael Eriksson; Stig E Bojesen; Børge G Nordestgaard; Sune F Nielsen; Henrik Flyger; Diether Lambrechts; Patrick Neven; Hans Wildiers; Giuseppe Floris; Marjanka K Schmidt; Matti A Rookus; Katja van den Hurk; Wim L A M de Kort; Fergus J Couch; Janet E Olson; Emily Hallberg; Celine Vachon; Anja Rudolph; Petra Seibold; Dieter Flesch-Janys; Julian Peto; Isabel Dos-Santos-Silva; Olivia Fletcher; Nichola Johnson; Heli Nevanlinna; Taru A Muranen; Kristiina Aittomäki; Carl Blomqvist; Jingmei Li; Keith Humphreys; Judith Brand; Pascal Guénel; Thérèse Truong; Emilie Cordina-Duverger; Florence Menegaux; Barbara Burwinkel; Frederik Marme; Rongxi Yang; Harald Surowy; Javier Benitez; M Pilar Zamora; Jose I A Perez; Angela Cox; Simon S Cross; Malcolm W R Reed; Irene L Andrulis; Julia A Knight; Gord Glendon; Sandrine Tchatchou; Elinor J Sawyer; Ian Tomlinson; Michael J Kerin; Nicola Miller; Georgia Chenevix-Trench; Christopher A Haiman; Brian E Henderson; Fredrick Schumacher; Loic Le Marchand; Annika Lindblom; Sara Margolin; Maartje J Hooning; John W M Martens; Madeleine M A Tilanus-Linthorst; J Margriet Collée; John L Hopper; Melissa C Southey; Helen Tsimiklis; Carmel Apicella; Susan Slager; Amanda E Toland; Christine B Ambrosone; Drakoulis Yannoukakos; Graham G Giles; Roger L Milne; Catriona McLean; Peter A Fasching; Lothar Haeberle; Arif B Ekici; Matthias W Beckmann; Hermann Brenner; Aida Karina Dieffenbach; Volker Arndt; Christa Stegmaier; Anthony J Swerdlow; Alan Ashworth; Nick Orr; Michael Jones; Jonine Figueroa; Montserrat Garcia-Closas; Louise Brinton; Jolanta Lissowska; Martine Dumont; Robert Winqvist; Katri Pylkäs; Arja Jukkola-Vuorinen; Mervi Grip; Hiltrud Brauch; Thomas Brüning; Yon-Dschun Ko; Paolo Peterlongo; Siranoush Manoukian; Bernardo Bonanni; Paolo Radice; Natalia Bogdanova; Natalia Antonenkova; Thilo Dörk; Arto Mannermaa; Vesa Kataja; Veli-Matti Kosma; Jaana M Hartikainen; Peter Devilee; Caroline Seynaeve; Christi J Van Asperen; Anna Jakubowska; Jan Lubiński; Katarzyna Jaworska-Bieniek; Katarzyna Durda; Ute Hamann; Diana Torres; Rita K Schmutzler; Susan L Neuhausen; Hoda Anton-Culver; Vessela N Kristensen; Grethe I Grenaker Alnæs; Brandon L Pierce; Peter Kraft; Ulrike Peters; Sara Lindstrom; Daniela Seminara; Stephen Burgess; Habibul Ahsan; Alice S Whittemore; Esther M John; Marilie D Gammon; Kathleen E Malone; Daniel C Tessier; Daniel Vincent; Francois Bacot; Craig Luccarini; Caroline Baynes; Shahana Ahmed; Mel Maranian; Catherine S Healey; Anna González-Neira; Guillermo Pita; M Rosario Alonso; Nuria Álvarez; Daniel Herrero; Paul D P Pharoah; Jacques Simard; Per Hall; David J Hunter; Douglas F Easton; Wei Zheng Journal: J Natl Cancer Inst Date: 2015-08-20 Impact factor: 13.506