Literature DB >> 2530302

Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells.

R Peleman1, J Wu, C Fargeas, G Delespesse.   

Abstract

rIL-4 inhibits the production of IFN-gamma by PBMC stimulated with mitogens or allogeneic cells. The suppression is observed at the protein and at the mRNA level; it is dose and time dependent, and it is abolished by a neutralizing mAb to IL-4. It is suggested that the balance between the production of IL-4 and IFN-gamma may be significantly influenced by the chronological order of activation of their respective gene.

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Year:  1989        PMID： 2530302      PMCID： PMC2189501          DOI： 10.1084/jem.170.5.1751

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  15 in total

1.  Hybridization of denatured RNA transferred or dotted nitrocellulose paper.

Authors:  P S Thomas
Journal:  Methods Enzymol       Date:  1983       Impact factor: 1.600

2.  Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production.

Authors:  C M Snapper; W E Paul
Journal:  Science       Date:  1987-05-22       Impact factor: 47.728

3.  Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that interferon-gamma is the activating lymphokine.

Authors:  H W Murray; B Y Rubin; C D Rothermel
Journal:  J Clin Invest       Date:  1983-10       Impact factor: 14.808

4.  In vitro synthesis of IgE by human lymphocytes. II. Enhancement of the spontaneous IgE synthesis by IgE-binding factors secreted by RPMI 8866 lymphoblastoid B cells.

Authors:  M Sarfati; E Rector; K Wong; M Rubio-Trujillo; A H Sehon; G Delespesse
Journal:  Immunology       Date:  1984-10       Impact factor: 7.397

5.  Regulation of IFN-gamma induction in human peripheral blood cells by exogenous and endogenously produced interleukin 2.

Authors:  J Vilcek; D Henriksen-Destefano; D Siegel; A Klion; R J Robb; J Le
Journal:  J Immunol       Date:  1985-09       Impact factor: 5.422

6.  IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.

Authors:  F D Finkelman; I M Katona; T R Mosmann; R L Coffman
Journal:  J Immunol       Date:  1988-02-15       Impact factor: 5.422

7.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors:  J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162

8.  Regulation of cytolytic cell populations from human peripheral blood by B cell stimulatory factor 1 (interleukin 4).

Authors:  M B Widmer; R B Acres; H M Sassenfeld; K H Grabstein
Journal:  J Exp Med       Date:  1987-11-01       Impact factor: 14.307

9.  Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.

Authors:  C F Nathan; H W Murray; M E Wiebe; B Y Rubin
Journal:  J Exp Med       Date:  1983-09-01       Impact factor: 14.307

10.  Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

Authors:  F P Heinzel; M D Sadick; B J Holaday; R L Coffman; R M Locksley
Journal:  J Exp Med       Date:  1989-01-01       Impact factor: 14.307
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  39 in total

1.  Heterogeneity of cytokine functions in HIV infection.

Authors:  S K Kundu; T C Merigan
Journal:  Immunology       Date:  1997-06       Impact factor: 7.397

2.  Naive human T cells can be a source of IL-4 during primary immune responses.

Authors:  D M Bullens; K Rafiq; A Kasran; S W Van Gool; J L Ceuppens
Journal:  Clin Exp Immunol       Date:  1999-12       Impact factor: 4.330

Review 3.  Interleukin-4. A regulatory protein.

Authors:  J H Jansen; W E Fibbe; R Willemze; J C Kluin-Nelemans
Journal:  Blut       Date:  1990-05

4.  Protective effect of exogenous recombinant mouse interferon-gamma and tumour necrosis factor-alpha on ectromelia virus infection in susceptible BALB/c mice.

Authors:  A V Atrasheuskaya; E K Bukin; T M Fredeking; G M Ignatyev
Journal:  Clin Exp Immunol       Date:  2004-05       Impact factor: 4.330

5.  Elimination of IgE regulatory rat CD8+ T cells in vivo differentially modulates interleukin-4 and interferon-gamma but not interleukin-2 production by splenic T cells.

Authors:  D Diaz-Sanchez; A Noble; D Z Staynov; T H Lee; D M Kemeny
Journal:  Immunology       Date:  1993-04       Impact factor: 7.397

6.  Predominance of IgG1 and IgG4 subclasses of anti-neutrophil cytoplasmic autoantibodies (ANCA) in patients with Wegener's granulomatosis and clinically related disorders.

Authors:  E Brouwer; J W Tervaert; G Horst; M G Huitema; M van der Giessen; P C Limburg; C G Kallenberg
Journal:  Clin Exp Immunol       Date:  1991-03       Impact factor: 4.330

7.  Interleukin 4 suppresses interleukin 2 and interferon gamma production by naive T cells stimulated by accessory cell-dependent receptor engagement.

Authors:  T Tanaka; J Hu-Li; R A Seder; B Fazekas de St Groth; W E Paul
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205

8.  Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes.

Authors:  M Kiniwa; M Gately; U Gubler; R Chizzonite; C Fargeas; G Delespesse
Journal:  J Clin Invest       Date:  1992-07       Impact factor: 14.808

9.  Cytokine regulation of murine leishmaniasis: interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice.

Authors:  M D Sadick; N Street; T R Mosmann; R M Locksley
Journal:  Infect Immun       Date:  1991-12       Impact factor: 3.441

10.  Interleukin-4 enhances interferon-gamma synthesis but inhibits development of interferon-gamma-producing cells.

Authors:  A Noble; D M Kemeny
Journal:  Immunology       Date:  1995-07       Impact factor: 7.397
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