Literature DB >> 25300714

Scientific rigor through videogames.

Adrien Treuille1, Rhiju Das2.   

Abstract

Hypothesis-driven experimentation - the scientific method - can be subverted by fraud, irreproducibility, and lack of rigorous predictive tests. A robust solution to these problems may be the 'massive open laboratory' model, recently embodied in the internet-scale videogame EteRNA. Deploying similar platforms throughout biology could enforce the scientific method more broadly.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Keywords:  RNA design; crowdsourcing; high-throughput experiments; reproducibility; transparency; videogame

Mesh:

Substances:

Year:  2014        PMID: 25300714     DOI: 10.1016/j.tibs.2014.08.005

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN: 0968-0004            Impact factor:   13.807


  6 in total

1.  Principles for Predicting RNA Secondary Structure Design Difficulty.

Authors:  Jeff Anderson-Lee; Eli Fisker; Vineet Kosaraju; Michelle Wu; Justin Kong; Jeehyung Lee; Minjae Lee; Mathew Zada; Adrien Treuille; Rhiju Das
Journal:  J Mol Biol       Date:  2016-02-17       Impact factor: 5.469

Review 2.  Crowdsourcing in biomedicine: challenges and opportunities.

Authors:  Ritu Khare; Benjamin M Good; Robert Leaman; Andrew I Su; Zhiyong Lu
Journal:  Brief Bioinform       Date:  2015-04-17       Impact factor: 11.622

Review 3.  Crowdsourcing biomedical research: leveraging communities as innovation engines.

Authors:  Julio Saez-Rodriguez; James C Costello; Stephen H Friend; Michael R Kellen; Lara Mangravite; Pablo Meyer; Thea Norman; Gustavo Stolovitzky
Journal:  Nat Rev Genet       Date:  2016-07-15       Impact factor: 53.242

4.  Scientific Discovery Games for Biomedical Research.

Authors:  Rhiju Das; Benjamin Keep; Peter Washington; Ingmar H Riedel-Kruse
Journal:  Annu Rev Biomed Data Sci       Date:  2019-07

5.  Misrepresentation and distortion of research in biomedical literature.

Authors:  Isabelle Boutron; Philippe Ravaud
Journal:  Proc Natl Acad Sci U S A       Date:  2018-03-13       Impact factor: 11.205

6.  Classification of RNA structure change by 'gazing' at experimental data.

Authors:  Chanin Tolson Woods; Alain Laederach
Journal:  Bioinformatics       Date:  2017-06-01       Impact factor: 6.937

  6 in total

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