PURPOSE: We examined whether consumption of total dairy and dairy subgroups was related to incident stroke and coronary heart disease (CHD) in a general older Dutch population. METHODS: The study involved 4,235 participants of the Rotterdam Study aged 55 and over who were free of cardiovascular disease (CVD) and diabetes at baseline (1990-1993). Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) for the intake of total dairy and dairy subgroups in relation to incident CVD events. RESULTS: Median intake of total dairy was 397 g/day, which mainly comprised low-fat dairy products (median intake of 247 g/day). During a median follow-up time of 17.3 years, 564 strokes (182 fatal) and 567 CHD events (350 fatal) occurred. Total dairy, milk, low-fat dairy, and fermented dairy were not significantly related to incident stroke or fatal stroke (p > 0.2 for upper vs. lower intake categories). High-fat dairy was significantly inversely related to fatal stroke (HR of 0.88 per 100 g/day; 95% CI 0.79, 0.99), but not to incident stroke (HR of 0.96 per 100 g/day; 95% CI 0.90, 1.02). Total dairy or dairy subgroups were not significantly related to incident CHD or fatal CHD (HRs between 0.98 and 1.05 per 100 g/day, all p > 0.35). CONCLUSIONS: In this long-term follow-up study of older Dutch subjects, total dairy consumption or the intake of specific dairy products was not related to the occurrence of CVD events. The observed inverse association between high-fat dairy and fatal stroke warrants confirmation in other studies.
PURPOSE: We examined whether consumption of total dairy and dairy subgroups was related to incident stroke and coronary heart disease (CHD) in a general older Dutch population. METHODS: The study involved 4,235 participants of the Rotterdam Study aged 55 and over who were free of cardiovascular disease (CVD) and diabetes at baseline (1990-1993). Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) for the intake of total dairy and dairy subgroups in relation to incident CVD events. RESULTS: Median intake of total dairy was 397 g/day, which mainly comprised low-fat dairy products (median intake of 247 g/day). During a median follow-up time of 17.3 years, 564 strokes (182 fatal) and 567 CHD events (350 fatal) occurred. Total dairy, milk, low-fat dairy, and fermented dairy were not significantly related to incident stroke or fatal stroke (p > 0.2 for upper vs. lower intake categories). High-fat dairy was significantly inversely related to fatal stroke (HR of 0.88 per 100 g/day; 95% CI 0.79, 0.99), but not to incident stroke (HR of 0.96 per 100 g/day; 95% CI 0.90, 1.02). Total dairy or dairy subgroups were not significantly related to incident CHD or fatal CHD (HRs between 0.98 and 1.05 per 100 g/day, all p > 0.35). CONCLUSIONS: In this long-term follow-up study of older Dutch subjects, total dairy consumption or the intake of specific dairy products was not related to the occurrence of CVD events. The observed inverse association between high-fat dairy and fatal stroke warrants confirmation in other studies.
Authors: Russell V Luepker; Fred S Apple; Robert H Christenson; Richard S Crow; Stephen P Fortmann; David Goff; Robert J Goldberg; Mary M Hand; Allan S Jaffe; Desmond G Julian; Daniel Levy; Teri Manolio; Shanthi Mendis; George Mensah; Andrzej Pajak; Ronald J Prineas; K Srinath Reddy; Veronique L Roger; Wayne D Rosamond; Eyal Shahar; A Richey Sharrett; Paul Sorlie; Hugh Tunstall-Pedoe Journal: Circulation Date: 2003-11-10 Impact factor: 29.690
Authors: Sabita S Soedamah-Muthu; Gabriel Masset; Lisa Verberne; Johanna M Geleijnse; Eric J Brunner Journal: Br J Nutr Date: 2012-06-07 Impact factor: 3.718
Authors: Sabita S Soedamah-Muthu; Lisa D M Verberne; Eric L Ding; Mariëlle F Engberink; Johanna M Geleijnse Journal: Hypertension Date: 2012-09-17 Impact factor: 10.190
Authors: K Maruyama; H Iso; C Date; S Kikuchi; Y Watanabe; Y Wada; Y Inaba; A Tamakoshi Journal: Nutr Metab Cardiovasc Dis Date: 2012-03-10 Impact factor: 4.222
Authors: Marcia C de Oliveira Otto; Dariush Mozaffarian; Daan Kromhout; Alain G Bertoni; Christopher T Sibley; David R Jacobs; Jennifer A Nettleton Journal: Am J Clin Nutr Date: 2012-07-03 Impact factor: 7.045
Authors: Sabita S Soedamah-Muthu; Eric L Ding; Wael K Al-Delaimy; Frank B Hu; Marielle F Engberink; Walter C Willett; Johanna M Geleijnse Journal: Am J Clin Nutr Date: 2010-11-10 Impact factor: 7.045
Authors: Adam M Bernstein; Qi Sun; Frank B Hu; Meir J Stampfer; JoAnn E Manson; Walter C Willett Journal: Circulation Date: 2010-08-16 Impact factor: 29.690
Authors: Annamari Kilkkinen; Paul Knekt; Antti Aro; Harri Rissanen; Jukka Marniemi; Markku Heliövaara; Olli Impivaara; Antti Reunanen Journal: Am J Epidemiol Date: 2009-09-17 Impact factor: 4.897
Authors: Renske G Wieberdink; M Arfan Ikram; Albert Hofman; Peter J Koudstaal; Monique M B Breteler Journal: Eur J Epidemiol Date: 2012-03-17 Impact factor: 8.082
Authors: Jimmy Chun Yu Louie; Victoria M Flood; George Burlutsky; Anna M Rangan; Timothy P Gill; Paul Mitchell Journal: Nutrients Date: 2013-02-06 Impact factor: 5.717
Authors: Albert Hofman; Guy G O Brusselle; Sarwa Darwish Murad; Cornelia M van Duijn; Oscar H Franco; André Goedegebure; M Arfan Ikram; Caroline C W Klaver; Tamar E C Nijsten; Robin P Peeters; Bruno H Ch Stricker; Henning W Tiemeier; André G Uitterlinden; Meike W Vernooij Journal: Eur J Epidemiol Date: 2015-09-19 Impact factor: 8.082
Authors: Linden M Thayer; Daniela C Pimentel; Janice C Smith; Beverly A Garcia; Laura Lee Sylvester; Tammy Kelly; Larry F Johnston; Alice S Ammerman; Thomas C Keyserling Journal: Am J Health Educ Date: 2016-12-29
Authors: Judit Companys; Laura Pla-Pagà; Lorena Calderón-Pérez; Elisabet Llauradó; Rosa Solà; Anna Pedret; Rosa M Valls Journal: Adv Nutr Date: 2020-07-01 Impact factor: 8.701
Authors: Maryam S Farvid; Akbar F Malekshah; Akram Pourshams; Hossein Poustchi; Sadaf G Sepanlou; Maryam Sharafkhah; Masoud Khoshnia; Mojtaba Farvid; Christian C Abnet; Farin Kamangar; Sanford M Dawsey; Paul Brennan; Paul D Pharoah; Paolo Boffetta; Walter C Willett; Reza Malekzadeh Journal: Am J Epidemiol Date: 2017-04-15 Impact factor: 4.897
Authors: Janette de Goede; Sabita S Soedamah-Muthu; An Pan; Lieke Gijsbers; Johanna M Geleijnse Journal: J Am Heart Assoc Date: 2016-05-20 Impact factor: 5.501