Literature DB >> 25291599

Crystal structure of the vitamin B3 transporter PnuC, a full-length SWEET homolog.

Michael Jaehme1, Albert Guskov1, Dirk Jan Slotboom1.   

Abstract

PnuC transporters catalyze cellular uptake of the NAD+ precursor nicotinamide riboside (NR) and belong to a large superfamily that includes the SWEET sugar transporters. We present a crystal structure of Neisseria mucosa PnuC, which adopts a highly symmetrical fold with 3+1+3 membrane topology not previously observed in any protein. The high symmetry of PnuC with a single NR bound in the center suggests a simple alternating-access translocation mechanism.

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Year:  2014        PMID： 25291599     DOI： 10.1038/nsmb.2909

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


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