Literature DB >> 25283553

Inhibition of the ANT(2")-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones.

Danielle R Hirsch1, Georgina Cox2, Michael P D'Erasmo1, Tushar Shakya2, Christine Meck1, Noushad Mohd3, Gerard D Wright2, Ryan P Murelli4.   

Abstract

Aminoglycoside-2"-O-nucleotidyltransferase ANT(2")-Ia is an aminoglycoside resistance enzyme prevalent among Gram-negative bacteria, and is one of the most common determinants of enzyme-dependant aminoglycoside-resistance. The following report outlines the use of our recently described oxidopyrylium cycloaddition/ring-opening strategy in the synthesis and profiling of a library of synthetic α-hydroxytropolones against ANT(2")-Ia. In addition, we show that two of these synthetic constructs are capable of rescuing gentamicin activity against ANT-(2")-Ia-expressing bacteria.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Aminoglycoside-2″-O-nucleotidyltransferase; Aminoglycosides; Bacterial Resistance; Gentamicin; α-Hydroxytropolones

Mesh：

Substances：

Year:  2014        PMID： 25283553      PMCID： PMC4798002          DOI： 10.1016/j.bmcl.2014.09.037

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  44 in total

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