Literature DB >> 14741271

Synthesis and evaluation of novel bacterial rRNA-binding benzimidazoles by mass spectrometry.

Yun He1, Jun Yang, Baogen Wu, Dale Robinson, Kelly Sprankle, Pei-Pei Kung, Kristin Lowery, V Mohan, Steve Hofstadler, Eric E Swayze, Rich Griffey.   

Abstract

A series of novel benzimidazoles were efficiently synthesized using both solution- and solid-phase chemistry. These compounds were found to bind to the bacterial 16S ribosomal RNA A-site with micromolar affinities using unique mass spectrometry-based assays.

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Year:  2004        PMID： 14741271     DOI： 10.1016/j.bmcl.2003.11.031

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Structure of the cytosine-cytosine mismatch in the thymidylate synthase mRNA binding site and analysis of its interaction with the aminoglycoside paromomycin.

Authors:  Tony J Tavares; Alexander V Beribisky; Philip E Johnson
Journal:  RNA       Date:  2009-03-27       Impact factor: 4.942

2.  Inhibition of the ANT(2")-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones.

Authors:  Danielle R Hirsch; Georgina Cox; Michael P D'Erasmo; Tushar Shakya; Christine Meck; Noushad Mohd; Gerard D Wright; Ryan P Murelli
Journal:  Bioorg Med Chem Lett       Date:  2014-09-19       Impact factor: 2.823

3.  Identifying the preferred RNA motifs and chemotypes that interact by probing millions of combinations.

Authors:  Tuan Tran; Matthew D Disney
Journal:  Nat Commun       Date:  2012       Impact factor: 14.919
  3 in total

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