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Literature DB >> 25280102

Posttranscriptional regulation of gene expression by Piwi proteins and piRNAs.

Abstract

Piwi proteins and Piwi-interacting RNAs (piRNAs) are essential for gametogenesis, embryogenesis, and stem cell maintenance in animals. Piwi proteins act on transposon RNAs by cleaving the RNAs and by interacting with factors involved in RNA regulation. Additionally, piRNAs generated from transposons and psuedogenes can be used by Piwi proteins to regulate mRNAs at the posttranscriptional level. Here we discuss piRNA biogenesis, recent findings on posttranscriptional regulation of mRNAs by the piRNA pathway, and the potential importance of this posttranscriptional regulation for a variety of biological processes such as gametogenesis, developmental transitions, and sex determination.

Entities: CellLine Chemical Disease Gene Species

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Year: 2014 PMID： 25280102 PMCID： PMC4185416 DOI： 10.1016/j.molcel.2014.09.012

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

100 in total

Review 1. piRNA pathway and the potential processing site, the nuage, in the Drosophila germline.

Authors: Jun Wei Pek; Veena S Patil; Toshie Kai
Journal: Dev Growth Differ Date: 2012-01 Impact factor: 2.053

Review 2. RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond.

Authors: Stephane E Castel; Robert A Martienssen
Journal: Nat Rev Genet Date: 2013-02 Impact factor: 53.242

3. Structure and function of Zucchini endoribonuclease in piRNA biogenesis.

Authors: Hiroshi Nishimasu; Hirotsugu Ishizu; Kuniaki Saito; Satoshi Fukuhara; Miharu K Kamatani; Luc Bonnefond; Naoki Matsumoto; Tomohiro Nishizawa; Keita Nakanaga; Junken Aoki; Ryuichiro Ishitani; Haruhiko Siomi; Mikiko C Siomi; Osamu Nureki
Journal: Nature Date: 2012-10-14 Impact factor: 49.962

4. GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells.

Authors: Yusuke Shiromoto; Satomi Kuramochi-Miyagawa; Akito Daiba; Shinichiro Chuma; Ami Katanaya; Akiko Katsumata; Ken Nishimura; Manami Ohtaka; Mahito Nakanishi; Toshinobu Nakamura; Koichi Yoshinaga; Noriko Asada; Shota Nakamura; Teruo Yasunaga; Kanako Kojima-Kita; Daisuke Itou; Tohru Kimura; Toru Nakano
Journal: RNA Date: 2013-04-23 Impact factor: 4.942

5. A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway.

Authors: Benjamin Czech; Jonathan B Preall; Jon McGinn; Gregory J Hannon
Journal: Mol Cell Date: 2013-05-09 Impact factor: 17.970

Review 6. Beyond transposons: the epigenetic and somatic functions of the Piwi-piRNA mechanism.

Authors: Jamy C Peng; Haifan Lin
Journal: Curr Opin Cell Biol Date: 2013-03-04 Impact factor: 8.382

7. piRNA-mediated transgenerational inheritance of an acquired trait.

Authors: Thomas Grentzinger; Claudia Armenise; Christine Brun; Bruno Mugat; Vincent Serrano; Alain Pelisson; Séverine Chambeyron
Journal: Genome Res Date: 2012-05-03 Impact factor: 9.043

8. CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors.

Authors: Weifeng Gu; Heng-Chi Lee; Daniel Chaves; Elaine M Youngman; Gregory J Pazour; Darryl Conte; Craig C Mello
Journal: Cell Date: 2012-12-21 Impact factor: 41.582

9. The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis.

Authors: Jonathan J Ipsaro; Astrid D Haase; Simon R Knott; Leemor Joshua-Tor; Gregory J Hannon
Journal: Nature Date: 2012-10-14 Impact factor: 49.962

10. The genetic makeup of the Drosophila piRNA pathway.

Authors: Dominik Handler; Katharina Meixner; Manfred Pizka; Kathrin Lauss; Christopher Schmied; Franz Sebastian Gruber; Julius Brennecke
Journal: Mol Cell Date: 2013-05-09 Impact factor: 17.970

67 in total

Review 1. Short RNA regulators: the past, the present, the future, and implications for precision medicine and health disparities.

Authors: Isidore Rigoutsos; Eric Londin; Yohei Kirino
Journal: Curr Opin Biotechnol Date: 2019-07-16 Impact factor: 9.740

Posttranscriptional regulation of gene expression by Piwi proteins and piRNAs.

Review 1. piRNA pathway and the potential processing site, the nuage, in the Drosophila germline.

Review 2. RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond.

3. Structure and function of Zucchini endoribonuclease in piRNA biogenesis.

4. GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells.

5. A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway.

Review 6. Beyond transposons: the epigenetic and somatic functions of the Piwi-piRNA mechanism.

7. piRNA-mediated transgenerational inheritance of an acquired trait.

8. CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors.

9. The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis.

10. The genetic makeup of the Drosophila piRNA pathway.

Review 1. Short RNA regulators: the past, the present, the future, and implications for precision medicine and health disparities.

Review 2. Regulation of breast cancer metastasis signaling by miRNAs.

3. Mitochondrial PIWI-interacting RNAs are novel biomarkers for clear cell renal cell carcinoma.

4. StarScan: a web server for scanning small RNA targets from degradome sequencing data.

Review 5. Non-coding RNAs: the riddle of the transcriptome and their perspectives in cancer.

6. 1700108J01Rik and 1700101O22Rik are mouse testis-specific long non-coding RNAs.

Review 7. Tapping the RNA world for therapeutics.

8. The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer.

9. MIWI prevents aneuploidy during meiosis by cleaving excess satellite RNA.

10. DEEPN as an Approach for Batch Processing of Yeast 2-Hybrid Interactions.