Literature DB >> 25266373

Organocatalysts of oxidative protein folding inspired by protein disulfide isomerase.

John C Lukesh1, Kristen A Andersen, Kelly K Wallin, Ronald T Raines.   

Abstract

Organocatalysts derived from diethylenetriamine effect the rapid isomerization of non-native protein disulfide bonds to native ones. These catalysts contain a pendant hydrophobic moiety to encourage interaction with the non-native state, and two thiol groups with low pKa values that form a disulfide bond with a high E°' value.

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Year:  2014        PMID： 25266373      PMCID： PMC4237591          DOI： 10.1039/c4ob01738b

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  56 in total

1.  Ribonuclease A.

Authors:  Ronald T. Raines
Journal:  Chem Rev       Date:  1998-05-07       Impact factor: 60.622

Review 2.  Protein disulfide isomerases exploit synergy between catalytic and specific binding domains.

Authors:  Robert B Freedman; Peter Klappa; Lloyd W Ruddock
Journal:  EMBO Rep       Date:  2002-02       Impact factor: 8.807

3.  The crystal structure of yeast protein disulfide isomerase suggests cooperativity between its active sites.

Authors:  Geng Tian; Song Xiang; Robert Noiva; William J Lennarz; Hermann Schindelin
Journal:  Cell       Date:  2006-01-13       Impact factor: 41.582

4.  Maturing antibody-drug conjugate pipeline hits 30.

Authors:  Asher Mullard
Journal:  Nat Rev Drug Discov       Date:  2013-05       Impact factor: 84.694

Review 5.  Tinkering with enzymes: what are we learning?

Authors:  J R Knowles
Journal:  Science       Date:  1987-06-05       Impact factor: 47.728

6.  Increased catalytic activity of protein disulfide isomerase using aromatic thiol based redox buffers.

Authors:  Jonathan D Gough; Watson J Lees
Journal:  Bioorg Med Chem Lett       Date:  2005-02-01       Impact factor: 2.823

7.  Hypersensitive substrate for ribonucleases.

Authors:  B R Kelemen; T A Klink; M A Behlke; S R Eubanks; P A Leland; R T Raines
Journal:  Nucleic Acids Res       Date:  1999-09-15       Impact factor: 16.971

8.  Diselenides as universal oxidative folding catalysts of diverse proteins.

Authors:  Joris Beld; Kenneth J Woycechowsky; Donald Hilvert
Journal:  J Biotechnol       Date:  2010-10-08       Impact factor: 3.307

9.  The CXC motif: a functional mimic of protein disulfide isomerase.

Authors:  Kenneth J Woycechowsky; Ronald T Raines
Journal:  Biochemistry       Date:  2003-05-13       Impact factor: 3.162

Review 10.  Catalysis of protein folding by protein disulfide isomerase and small-molecule mimics.

Authors:  Elizabeth A Kersteen; Ronald T Raines
Journal:  Antioxid Redox Signal       Date:  2003-08       Impact factor: 8.401
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  3 in total

Review 1.  Chemistry and Enzymology of Disulfide Cross-Linking in Proteins.

Authors:  Deborah Fass; Colin Thorpe
Journal:  Chem Rev       Date:  2017-07-12       Impact factor: 60.622

2.  Conjugate of Thiol and Guanidyl Units with Oligoethylene Glycol Linkage for Manipulation of Oxidative Protein Folding.

Authors:  Shunsuke Okada; Motonori Matsusaki; Masaki Okumura; Takahiro Muraoka
Journal:  Molecules       Date:  2021-02-07       Impact factor: 4.411

Review 3.  Flexible Folding: Disulfide-Containing Peptides and Proteins Choose the Pathway Depending on the Environments.

Authors:  Kenta Arai; Michio Iwaoka
Journal:  Molecules       Date:  2021-01-02       Impact factor: 4.411
  3 in total

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