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Literature DB >> 2524599

Viral protein R of human immunodeficiency virus types 1 and 2 is dispensable for replication and cytopathogenicity in lymphoid cells.

D Dedera¹, W Hu, N Vander Heyden, L Ratner.

Abstract

Viral protein R (VPR) is conserved in human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2). To assess its function, we have constructed mutations within the vpr coding regions of HIV-1 and HIV-2 predicted to express truncated VPR products. Infectious virus was produced by each proviral clone and showed similar replication kinetics and cytopathogenicity when compared with the corresponding parental proviral clone.

Entities: Disease Species

Mesh：

Substances：

Year: 1989 PMID： 2524599 PMCID： PMC250884

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

16 in total

1. Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus.

Authors: P Sonigo; M Alizon; K Staskus; D Klatzmann; S Cole; O Danos; E Retzel; P Tiollais; A Haase; S Wain-Hobson
Journal: Cell Date: 1985-08 Impact factor: 41.582

2. Complete nucleotide sequences of functional clones of the AIDS virus.

Authors: L Ratner; A Fisher; L L Jagodzinski; H Mitsuya; R S Liou; R C Gallo; F Wong-Staal
Journal: AIDS Res Hum Retroviruses Date: 1987 Impact factor: 2.205

3. Rapid and efficient site-specific mutagenesis without phenotypic selection.

Authors: T A Kunkel
Journal: Proc Natl Acad Sci U S A Date: 1985-01 Impact factor: 11.205

4. Genome organization and transactivation of the human immunodeficiency virus type 2.

Authors: M Guyader; M Emerman; P Sonigo; F Clavel; L Montagnier; M Alizon
Journal: Nature Date: 1987 Apr 16-22 Impact factor: 49.962

5. Human immunodeficiency virus: the eighth gene.

Authors: F Wong-Staal; P K Chanda; J Ghrayeb
Journal: AIDS Res Hum Retroviruses Date: 1987 Impact factor: 2.205

6. The sor gene of HIV-1 is required for efficient virus transmission in vitro.

Authors: A G Fisher; B Ensoli; L Ivanoff; M Chamberlain; S Petteway; L Ratner; R C Gallo; F Wong-Staal
Journal: Science Date: 1987-08-21 Impact factor: 47.728

7. DNA sequencing with chain-terminating inhibitors.

Authors: F Sanger; S Nicklen; A R Coulson
Journal: Proc Natl Acad Sci U S A Date: 1977-12 Impact factor: 11.205

8. Nonrandom loss of chromosome 15 in Syrian hamster tumours induced by v-Ha-ras plus v-myc oncogenes.

Authors: M Oshimura; T M Gilmer; J C Barrett
Journal: Nature Date: 1985 Aug 15-21 Impact factor: 49.962

9. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma.

Authors: B J Poiesz; F W Ruscetti; A F Gazdar; P A Bunn; J D Minna; R C Gallo
Journal: Proc Natl Acad Sci U S A Date: 1980-12 Impact factor: 11.205

10. Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian retroviruses.

Authors: L Chakrabarti; M Guyader; M Alizon; M D Daniel; R C Desrosiers; P Tiollais; P Sonigo
Journal: Nature Date: 1987 Aug 6-12 Impact factor: 49.962

45 in total

1. Influenza A virus can undergo multiple cycles of replication without M2 ion channel activity.

Authors: T Watanabe; S Watanabe; H Ito; H Kida; Y Kawaoka
Journal: J Virol Date: 2001-06 Impact factor: 5.103

2. Impairment of human immunodeficiency virus type 1 (HIV-1) entry into Jurkat T cells by constitutive expression of the HIV-1 vpr protein: role of CD4 down-modulation.

Authors: L Conti; B Varano; M C Gauzzi; P Matarrese; M Federico; W Malorni; F Belardelli; S Gessani
Journal: J Virol Date: 2000-11 Impact factor: 5.103

3. The human immunodeficiency virus type 2 vpr gene is essential for productive infection of human macrophages.

Authors: N Hattori; F Michaels; K Fargnoli; L Marcon; R C Gallo; G Franchini
Journal: Proc Natl Acad Sci U S A Date: 1990-10 Impact factor: 11.205

4. Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes.

Authors: D H Gabuzda; K Lawrence; E Langhoff; E Terwilliger; T Dorfman; W A Haseltine; J Sodroski
Journal: J Virol Date: 1992-11 Impact factor: 5.103

5. Dual regulation of silent and productive infection in monocytes by distinct human immunodeficiency virus type 1 determinants.

Authors: P Westervelt; T Henkel; D B Trowbridge; J Orenstein; J Heuser; H E Gendelman; L Ratner
Journal: J Virol Date: 1992-06 Impact factor: 5.103

6. Vpr Enhances Tumor Necrosis Factor Production by HIV-1-Infected T Cells.

Authors: Ferdinand Roesch; Léa Richard; Réjane Rua; Françoise Porrot; Nicoletta Casartelli; Olivier Schwartz
Journal: J Virol Date: 2015-09-23 Impact factor: 5.103

7. Generation and characterization of infectious chimeric clones between human immunodeficiency virus type 1 and simian immunodeficiency virus from an African green monkey.

Authors: R Shibata; H Sakai; T Kiyomasu; A Ishimoto; M Hayami; A Adachi
Journal: J Virol Date: 1990-12 Impact factor: 5.103

8. A leucine triplet repeat sequence (LXX)4 in p6gag is important for Vpr incorporation into human immunodeficiency virus type 1 particles.

Authors: Y L Lu; R P Bennett; J W Wills; R Gorelick; L Ratner
Journal: J Virol Date: 1995-11 Impact factor: 5.103

9. A domain of human immunodeficiency virus type 1 Vpr containing repeated H(S/F)RIG amino acid motifs causes cell growth arrest and structural defects.

Authors: I G Macreadie; L A Castelli; D R Hewish; A Kirkpatrick; A C Ward; A A Azad
Journal: Proc Natl Acad Sci U S A Date: 1995-03-28 Impact factor: 11.205

10. The p6gag domain of human immunodeficiency virus type 1 is sufficient for the incorporation of Vpr into heterologous viral particles.

Authors: E Kondo; F Mammano; E A Cohen; H G Göttlinger
Journal: J Virol Date: 1995-05 Impact factor: 5.103