Haiyan Ding1,2, Laura Fernandez-de-Manuel2,3, Michael Schär4,5, Karl H Schuleri6, Henry Halperin6, Le He1, M Muz Zviman6, Roy Beinart6,7, Daniel A Herzka2. 1. Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, People's Republic of China. 2. Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. 3. Biomedical Image Technologies Laboratory, ETSI Telecomunicación, Universidad Politécnica de Madrid, and CIBER-BBN, Madrid, Spain. 4. Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. 5. Philips Healthcare, Cleveland, Ohio, USA. 6. Department of Medicine, Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. 7. Heart Institute, Sheba Medical Center, Tel Aviv University, Ramat Gan, Israel.
Abstract
PURPOSE: Detecting variations in myocardial water content with T2 mapping is superior to conventional T2 -weighted MRI since quantification enables direct observation of complicated pathology. Most commonly used T2 mapping techniques are limited in achievable spatial and/or temporal resolution, both of which reduce accuracy due to partial-volume averaging and misregistration between images. The goal of this study was to validate a novel free breathing T2 mapping sequence that overcomes these limitations. METHODS: The proposed technique was made insensitive to heart rate variability through the use of a saturation prepulse to reset magnetization every heartbeat. Respiratory navigator-gated, differentially T2 -weighted volumes were interleaved per heartbeat, guaranteeing registered images and robust voxel-by-voxel T2 maps. Free breathing acquisitions removed limits on spatial resolution and allowed short diastolic windows. Accuracy was quantified with simulations and phantoms. RESULTS: Homogeneous three-dimensional (3D) T2 maps were obtained from normal human subjects and swine. Normal human and swine left ventricular T2 values were 42.3 ± 4.0 and 43.5 ± 4.3 ms, respectively. The T2 value for edematous myocardium obtained from a swine model of acute myocardial infarction was 59.1 ± 7.1 ms. CONCLUSION: Free-breathing accurate 3D T2 mapping is feasible and may be applicable in myocardial assessment in lieu of current clinical black blood, T2 -weighted techniques.
PURPOSE: Detecting variations in myocardial water content with T2 mapping is superior to conventional T2 -weighted MRI since quantification enables direct observation of complicated pathology. Most commonly used T2 mapping techniques are limited in achievable spatial and/or temporal resolution, both of which reduce accuracy due to partial-volume averaging and misregistration between images. The goal of this study was to validate a novel free breathing T2 mapping sequence that overcomes these limitations. METHODS: The proposed technique was made insensitive to heart rate variability through the use of a saturation prepulse to reset magnetization every heartbeat. Respiratory navigator-gated, differentially T2 -weighted volumes were interleaved per heartbeat, guaranteeing registered images and robust voxel-by-voxel T2 maps. Free breathing acquisitions removed limits on spatial resolution and allowed short diastolic windows. Accuracy was quantified with simulations and phantoms. RESULTS: Homogeneous three-dimensional (3D) T2 maps were obtained from normal human subjects and swine. Normal human and swine left ventricular T2 values were 42.3 ± 4.0 and 43.5 ± 4.3 ms, respectively. The T2 value for edematous myocardium obtained from a swine model of acute myocardial infarction was 59.1 ± 7.1 ms. CONCLUSION: Free-breathing accurate 3D T2 mapping is feasible and may be applicable in myocardial assessment in lieu of current clinical black blood, T2 -weighted techniques.
Authors: Bridgette Webb; Martin Manninger; Marlene Leoni; Thomas Widek; Martin Dobrovnik; Daniel Scherr; Rudolf Stollberger; Thorsten Schwark Journal: Int J Legal Med Date: 2019-12-18 Impact factor: 2.686
Authors: Dengrong Jiang; Hanzhang Lu; Charlamaine Parkinson; Pan Su; Zhiliang Wei; Li Pan; Aylin Tekes; Thierry A G M Huisman; W Christopher Golden; Peiying Liu Journal: Magn Reson Med Date: 2019-05-07 Impact factor: 4.668
Authors: Tevfik F Ismail; Wendy Strugnell; Chiara Coletti; Maša Božić-Iven; Sebastian Weingärtner; Kerstin Hammernik; Teresa Correia; Thomas Küstner Journal: Front Cardiovasc Med Date: 2022-03-03
Authors: Ingo Hermann; Peter Kellman; Omer B Demirel; Mehmet Akçakaya; Lothar R Schad; Sebastian Weingärtner Journal: Magn Reson Med Date: 2021-03-29 Impact factor: 4.668