Literature DB >> 25232507

The Oct4 protein: more than a magic stemness marker.

Dana Zeineddine1, Aya Abou Hammoud2, Mohamad Mortada1, Hélène Boeuf3.   

Abstract

The Oct4 protein, encoded by the Pou5f1 gene was the very first master gene, discovered 25 years ago, to be absolutely required for the stemness properties of murine and primate embryonic stem cells. This transcription factor, which has also been shown to be essential for somatic cell reprogrammation, displays various functions depending upon its level of expression and has been quoted as a "rheostat" gene. Oct4 protein is in complexes with many different partners and its activity depends upon fine post-translational modifications. This review aims at revisiting some properties of this protein, which has not yet delivered all its potentialities.

Entities:  

Keywords:  Oct4/ Pou5f1; cancer stem cells; cell lineages; embryonic stem cells; pluripotency

Year:  2014        PMID： 25232507      PMCID： PMC4163606     

Source DB:  PubMed          Journal:  Am J Stem Cells        ISSN： 2160-4150


  81 in total

Review 1.  Post-translational modulation of pluripotency.

Authors:  Ning Cai; Mo Li; Jing Qu; Guang-Hui Liu; Juan Carlos Izpisua Belmonte
Journal:  J Mol Cell Biol       Date:  2012-06-07       Impact factor: 6.216

2.  Oct4 is required for primordial germ cell survival.

Authors:  James Kehler; Elena Tolkunova; Birgit Koschorz; Maurizio Pesce; Luca Gentile; Michele Boiani; Hilda Lomelí; Andras Nagy; K John McLaughlin; Hans R Schöler; Alexey Tomilin
Journal:  EMBO Rep       Date:  2004-11       Impact factor: 8.807

3.  Core transcriptional regulatory circuitry in human embryonic stem cells.

Authors:  Laurie A Boyer; Tong Ihn Lee; Megan F Cole; Sarah E Johnstone; Stuart S Levine; Jacob P Zucker; Matthew G Guenther; Roshan M Kumar; Heather L Murray; Richard G Jenner; David K Gifford; Douglas A Melton; Rudolf Jaenisch; Richard A Young
Journal:  Cell       Date:  2005-09-23       Impact factor: 41.582

Review 4.  Krüppel-like transcription factors and control of pluripotency.

Authors:  Pierre-Yves Bourillot; Pierre Savatier
Journal:  BMC Biol       Date:  2010-09-27       Impact factor: 7.431

5.  Oct4 is a critical regulator of stemness in head and neck squamous carcinoma cells.

Authors:  B S Koo; S H Lee; J M Kim; S Huang; S H Kim; Y S Rho; W J Bae; H J Kang; Y S Kim; J H Moon; Y C Lim
Journal:  Oncogene       Date:  2014-06-23       Impact factor: 9.867

6.  POU5F1 isoforms show different expression patterns in human embryonic stem cells and preimplantation embryos.

Authors:  Greet Cauffman; Inge Liebaers; André Van Steirteghem; Hilde Van de Velde
Journal:  Stem Cells       Date:  2006-08-17       Impact factor: 6.277

Review 7.  Epigenetic control of embryonic stem cell fate.

Authors:  Nicolaj Strøyer Christophersen; Kristian Helin
Journal:  J Exp Med       Date:  2010-10-25       Impact factor: 14.307

8.  Structure, expression and chromosomal location of the Oct-4 gene.

Authors:  Y I Yeom; H S Ha; R Balling; H R Schöler; K Artzt
Journal:  Mech Dev       Date:  1991-11       Impact factor: 1.882

Review 9.  Mechanisms and models of somatic cell reprogramming.

Authors:  Yosef Buganim; Dina A Faddah; Rudolf Jaenisch
Journal:  Nat Rev Genet       Date:  2013-06       Impact factor: 53.242

10.  Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden.

Authors:  Khalid Abubaker; Rodney B Luwor; Hongjian Zhu; Orla McNally; Michael A Quinn; Christopher J Burns; Erik W Thompson; Jock K Findlay; Nuzhat Ahmed
Journal:  BMC Cancer       Date:  2014-05-06       Impact factor: 4.430
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  66 in total

1.  Biopolymer-delivered vascular endothelial growth factor improves renal outcomes following revascularization.

Authors:  Erika Guise; Jason E Engel; Maxx L Williams; Fakhri Mahdi; Gene L Bidwell; Alejandro R Chade
Journal:  Am J Physiol Renal Physiol       Date:  2019-03-20

2.  Blockade of TLR4 using TAK-242 (resatorvid) enhances anti-cancer effects of chemotherapeutic agents: a novel synergistic approach for breast and ovarian cancers.

Authors:  Bahareh Kashani; Zahra Zandi; Mohammad Reza Karimzadeh; Davood Bashash; Ali Nasrollahzadeh; Seyed H Ghaffari
Journal:  Immunol Res       Date:  2019-12       Impact factor: 2.829

3.  Oct4 Is Crucial for Transdifferentiation of Hepatocytes to Biliary Epithelial Cells in an In Vitro Organoid Culture Model.

Authors:  Mboya Doffou; George Adams; William C Bowen; Shirish Paranjpe; Harish S Parihar; Huy Nguyen; George K Michalopoulos; Vishakha S Bhave
Journal:  Gene Expr       Date:  2017-12-06

4.  SOX2 and Rb1 in esophageal small-cell carcinoma: their possible involvement in pathogenesis.

Authors:  Hirotaka Ishida; Atsuko Kasajima; Takashi Kamei; Tsuyoshi Miura; Naomi Oka; Samaneh Yazdani; Yohei Ozawa; Fumiyoshi Fujishima; Akira Sakurada; Yasuhiro Nakamura; Yoichi Tanaka; Masafumi Kurosumi; Yuichi Ishikawa; Yoshinori Okada; Noriaki Ohuchi; Hironobu Sasano
Journal:  Mod Pathol       Date:  2017-01-20       Impact factor: 7.842

5.  Microarray-based Analysis of Genes, Transcription Factors, and Epigenetic Modifications in Lung Cancer Exposed to Nitric Oxide.

Authors:  Arnatchai Maiuthed; Ornjira Prakhongcheep; Pithi Chanvorachote
Journal:  Cancer Genomics Proteomics       Date:  2020 Jul-Aug       Impact factor: 4.069

6.  Nitric oxide promotes cancer cell dedifferentiation by disrupting an Oct4:caveolin-1 complex: A new regulatory mechanism for cancer stem cell formation.

Authors:  Arnatchai Maiuthed; Narumol Bhummaphan; Sudjit Luanpitpong; Apiwat Mutirangura; Chatchawit Aporntewan; Arthitaya Meeprasert; Thanyada Rungrotmongkol; Yon Rojanasakul; Pithi Chanvorachote
Journal:  J Biol Chem       Date:  2018-07-09       Impact factor: 5.157

7.  Knockdown of OCT4 may sensitize NSCLC cells to cisplatin.

Authors:  X Liu; M Ma; X Duan; H Zhang; M Yang
Journal:  Clin Transl Oncol       Date:  2016-11-10       Impact factor: 3.405

8.  High expression of Zinc-finger protein X-linked is associated with reduced E-cadherin expression and unfavorable prognosis in nasopharyngeal carcinoma.

Authors:  Yin Li; Xuebing Yan; Leilei Yan; Zezhi Shan; Sihong Liu; Xiaojuan Chen; Jianyin Zou; Weitian Zhang; Zhiming Jin
Journal:  Int J Clin Exp Pathol       Date:  2015-04-01

9.  Transcription factor Oct4 promotes osteosarcoma by regulating lncRNA AK055347.

Authors:  Hongwu Fan; Guangyao Liu; Changfu Zhao; Xuefeng Li; Xiaoyu Yang
Journal:  Oncol Lett       Date:  2016-11-21       Impact factor: 2.967

10.  Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis.

Authors:  Fei Li; Myles H Alderman; Aya Tal; Ramanaiah Mamillapalli; Alexis Coolidge; Demetra Hufnagel; Zhihao Wang; Elham Neisani; Stephanie Gidicsin; Graciela Krikun; Hugh S Taylor
Journal:  Stem Cells       Date:  2018-03-01       Impact factor: 6.277
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