Literature DB >> 25232505

Metastatic cancer stem cells: from the concept to therapeutics.

Wen-Ting Liao1, Ya-Ping Ye1, Yong-Jian Deng1, Xiu-Wu Bian2, Yan-Qing Ding1.   

Abstract

Metastatic cancer stem cells (MCSCs) refer to a subpopulation of cancer cells with both stem cell properties and invasion capabilities that contribute to cancer metastasis. MCSCs have capability of self-renewal, potentials of multiple differentiation and development and/or reconstruction of cancer tissues. As compared with stationary cancer stem cells, MCSCs are capable of invasion to normal tissues such as vasculatures, resistance to chemo- and/or radio-therapies, escape from immune surveillance, survival in circulation and formation of metastasis. MCSCs are derived from invasive cancer stem cells (iCSCs) due to the plasticity of cancer stem cells, which is one of the characteristics of cancer cell heterogeneity. Both stages of iCSCs and MSCSs are the potential therapeutic targets for cancer metastasis in the future strategies of personalized cancer therapy.

Entities:  

Keywords:  Cancer stem cells; invasion and metastasis; therapeutics

Year:  2014        PMID： 25232505      PMCID： PMC4163604     

Source DB:  PubMed          Journal:  Am J Stem Cells        ISSN： 2160-4150


  169 in total

1.  Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells.

Authors:  Yohei Shimono; Maider Zabala; Robert W Cho; Neethan Lobo; Piero Dalerba; Dalong Qian; Maximilian Diehn; Huiping Liu; Sarita P Panula; Eric Chiao; Frederick M Dirbas; George Somlo; Renee A Reijo Pera; Kaiqin Lao; Michael F Clarke
Journal:  Cell       Date:  2009-08-07       Impact factor: 41.582

Review 2.  Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression.

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Journal:  Nat Rev Cancer       Date:  2005-09       Impact factor: 60.716

3.  Enhanced cell migration and invasion of CD133+ pancreatic cancer cells cocultured with pancreatic stromal cells.

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Journal:  Cancer       Date:  2010-07-15       Impact factor: 6.860

4.  CXCR4 positive cells from Lewis lung carcinoma cell line have cancer metastatic stem cell characteristics.

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Journal:  Mol Cell Biochem       Date:  2011-05-07       Impact factor: 3.396

5.  Mobilized bone marrow cells repair the infarcted heart, improving function and survival.

Authors:  D Orlic; J Kajstura; S Chimenti; F Limana; I Jakoniuk; F Quaini; B Nadal-Ginard; D M Bodine; A Leri; P Anversa
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-14       Impact factor: 11.205

6.  DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells.

Authors:  Andreas Eger; Kirsten Aigner; Stefan Sonderegger; Brigitta Dampier; Susanne Oehler; Martin Schreiber; Geert Berx; Amparo Cano; Hartmut Beug; Roland Foisner
Journal:  Oncogene       Date:  2005-03-31       Impact factor: 9.867

7.  CXCR4 regulates growth of both primary and metastatic breast cancer.

Authors:  Matthew C P Smith; Kathryn E Luker; Joel R Garbow; Julie L Prior; Erin Jackson; David Piwnica-Worms; Gary D Luker
Journal:  Cancer Res       Date:  2004-12-01       Impact factor: 12.701

Review 8.  Metastatic potential: generic predisposition of the primary tumor or rare, metastatic variants-or both?

Authors:  Richard O Hynes
Journal:  Cell       Date:  2003-06-27       Impact factor: 41.582

9.  TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells.

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Journal:  Oncogene       Date:  2014-02-17       Impact factor: 9.867

Review 10.  Cancer stem cells, hypoxia and metastasis.

Authors:  Richard P Hill; Delphine T Marie-Egyptienne; David W Hedley
Journal:  Semin Radiat Oncol       Date:  2009-04       Impact factor: 5.934
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  46 in total

1.  Chemoradiation therapy reduces aldehyde dehydrogenase 1 expression in cervical cancer but does not improve patient survival.

Authors:  Yin Lv; Lin Yang; Fan Wang
Journal:  Med Oncol       Date:  2015-04-03       Impact factor: 3.064

2.  Breast Cancer Metastasis.

Authors:  Mi Young Kim
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 3.  Sustained proliferation in cancer: Mechanisms and novel therapeutic targets.

Authors:  Mark A Feitelson; Alla Arzumanyan; Rob J Kulathinal; Stacy W Blain; Randall F Holcombe; Jamal Mahajna; Maria Marino; Maria L Martinez-Chantar; Roman Nawroth; Isidro Sanchez-Garcia; Dipali Sharma; Neeraj K Saxena; Neetu Singh; Panagiotis J Vlachostergios; Shanchun Guo; Kanya Honoki; Hiromasa Fujii; Alexandros G Georgakilas; Alan Bilsland; Amedeo Amedei; Elena Niccolai; Amr Amin; S Salman Ashraf; Chandra S Boosani; Gunjan Guha; Maria Rosa Ciriolo; Katia Aquilano; Sophie Chen; Sulma I Mohammed; Asfar S Azmi; Dipita Bhakta; Dorota Halicka; W Nicol Keith; Somaira Nowsheen
Journal:  Semin Cancer Biol       Date:  2015-04-17       Impact factor: 15.707

4.  CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling.

Authors:  Xiang Zhang; Lu Chen; Wei-Qi Dang; Mian-Fu Cao; Jing-Fang Xiao; Sheng-Qing Lv; Wen-Jie Jiang; Xiao-Hong Yao; Hui-Min Lu; Jing-Ya Miao; Yan Wang; Shi-Cang Yu; Yi-Fang Ping; Xin-Dong Liu; You-Hong Cui; Xia Zhang; Xiu-Wu Bian
Journal:  Lab Invest       Date:  2019-11-20       Impact factor: 5.662

Review 5.  Perspective: Cooperation of Nanog, NF-κΒ, and CXCR4 in a regulatory network for directed migration of cancer stem cells.

Authors:  Masoumeh Es-Haghi; Sara Soltanian; Hesam Dehghani
Journal:  Tumour Biol       Date:  2015-12-29

Review 6.  Targeting Notch signalling pathway of cancer stem cells.

Authors:  Vandana Venkatesh; Raghu Nataraj; Gopenath S Thangaraj; Murugesan Karthikeyan; Ashok Gnanasekaran; Shanmukhappa B Kaginelli; Gobianand Kuppanna; Chandrashekrappa Gowdru Kallappa; Kanthesh M Basalingappa
Journal:  Stem Cell Investig       Date:  2018-03-12

7.  Blocking Stemness and Metastatic Properties of Ovarian Cancer Cells by Targeting p70S6K with Dendrimer Nanovector-Based siRNA Delivery.

Authors:  Jing Ma; Shashwati Kala; Susan Yung; Tak Mao Chan; Yu Cao; Yifan Jiang; Xiaoxuan Liu; Suzanne Giorgio; Ling Peng; Alice S T Wong
Journal:  Mol Ther       Date:  2017-11-16       Impact factor: 11.454

Review 8.  Circulating cancer stem cells: the importance to select.

Authors:  Ming-Hsin Yang; Ahmet Imrali; Christopher Heeschen
Journal:  Chin J Cancer Res       Date:  2015-10       Impact factor: 5.087

9.  The role of miR-145 in stem cell characteristics of human laryngeal squamous cell carcinoma Hep-2 cells.

Authors:  Omer Faruk Karatas; Ilknur Suer; Betul Yuceturk; Mehmet Yilmaz; Yusif Hajiyev; Chad J Creighton; Michael Ittmann; Mustafa Ozen
Journal:  Tumour Biol       Date:  2015-10-22

10.  Overexpression of DDIT4 and TPTEP1 are associated with metastasis and advanced stages in colorectal cancer patients: a study utilizing bioinformatics prediction and experimental validation.

Authors:  Fahimeh Fattahi; Jafar Kiani; Mahdi Alemrajabi; Ahmadreza Soroush; Marzieh Naseri; Mohammad Najafi; Zahra Madjd
Journal:  Cancer Cell Int       Date:  2021-06-09       Impact factor: 5.722
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