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Literature DB >> 26715265

Perspective: Cooperation of Nanog, NF-κΒ, and CXCR4 in a regulatory network for directed migration of cancer stem cells.

Masoumeh Es-Haghi¹, Sara Soltanian², Hesam Dehghani^3,4.

Abstract

Directed cell migration is a crucial mobility phase of cancer stem cells having stemness and tumorigenic characteristics. It is known that CXCR4 plays key roles in the perception of chemotactic gradients throughout the directed migration of CSCs. There are a number of complex signaling pathways and transcription factors that coordinate with CXCR4/CXCL12 axis during directed migration. In this review, we focus on some transcription factors such as Nanog, NF-κB, and Bmi-1 that cooperate with CXCR4/CXCL12 for the maintenance of stemness and induction of metastasis behavior in cancer stem cells.

Entities: Disease Gene

Keywords: CXCR4/CXCL12 axis; Cancer stem cell; Directed cell migration; Metastasis; NF-κB; Nanog; Stemness

Mesh：

Substances：

Year: 2015 PMID： 26715265 DOI： 10.1007/s13277-015-4690-6

Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283

34 in total

Review 1. Tumor metastasis: molecular insights and evolving paradigms.

Authors: Scott Valastyan; Robert A Weinberg
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2. Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.

Authors: Mitomu Kioi; Hannes Vogel; Geoffrey Schultz; Robert M Hoffman; Griffith R Harsh; J Martin Brown
Journal: J Clin Invest Date: 2010-02-22 Impact factor: 14.808

3. CXCR4 as a novel predictive biomarker for metastasis and poor prognosis in colorectal cancer.

Authors: Ying Gao; Chunyu Li; Min Nie; Yao Lu; Shunsen Lin; Peng Yuan; Xun Sun
Journal: Tumour Biol Date: 2014-01-07

4. The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network.

Authors: M Fareh; L Turchi; V Virolle; D Debruyne; F Almairac; S de-la-Forest Divonne; P Paquis; O Preynat-Seauve; K-H Krause; H Chneiweiss; T Virolle
Journal: Cell Death Differ Date: 2011-07-01 Impact factor: 15.828

Review 5. Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch.

Authors: Lindsay B Case; Clare M Waterman
Journal: Nat Cell Biol Date: 2015-06-29 Impact factor: 28.824

Review 6. The role of CXCR4 in highly malignant human gliomas biology: current knowledge and future directions.

Authors: Filippo Gagliardi; Ashwin Narayanan; Michele Reni; Alberto Franzin; Elena Mazza; Nicola Boari; Michele Bailo; Paola Zordan; Pietro Mortini
Journal: Glia Date: 2014-04-08 Impact factor: 7.452

Review 7. The significance of cancer cell expression of the chemokine receptor CXCR4.

Authors: Fran Balkwill
Journal: Semin Cancer Biol Date: 2004-06 Impact factor: 15.707

Review 8. The intricate role of CXCR4 in cancer.

Authors: Samit Chatterjee; Babak Behnam Azad; Sridhar Nimmagadda
Journal: Adv Cancer Res Date: 2014 Impact factor: 6.242

Review 9. Cancer stem cells and the tumor microenvironment: interplay in tumor heterogeneity.

Authors: Adriana Albini; Antonino Bruno; Cristina Gallo; Giorgio Pajardi; Douglas M Noonan; Katiuscia Dallaglio
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Review 10. Tumour heterogeneity and cancer cell plasticity.

Authors: Corbin E Meacham; Sean J Morrison
Journal: Nature Date: 2013-09-19 Impact factor: 49.962

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Review 2. Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy.

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4. The CXCR4 antagonist plerixafor enhances the effect of rituximab in diffuse large B-cell lymphoma cell lines.

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Review 5. The NF-κB Pathway and Cancer Stem Cells.

Authors: Amanda L Rinkenbaugh; Albert S Baldwin
Journal: Cells Date: 2016-04-06 Impact factor: 6.600

6. FtH-Mediated ROS Dysregulation Promotes CXCL12/CXCR4 Axis Activation and EMT-Like Trans-Differentiation in Erythroleukemia K562 Cells.

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Review 7. BORIS: a key regulator of cancer stemness.

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Journal: Cancer Cell Int Date: 2018-10-05 Impact factor: 5.722

8. SDF-1/CXCR4 induces cell invasion through CD147 in squamous cell carcinoma of the hypopharynx.

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9. Reduction in O-glycome induces differentially glycosylated CD44 to promote stemness and metastasis in pancreatic cancer.

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Review 10. Cancer stem cell secretome in the tumor microenvironment: a key point for an effective personalized cancer treatment.

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