Literature DB >> 25215

Nasal absorption of insulin in dogs.

S Harai, T Ikenaga, T Matsuzawa.   

Abstract

The intranasal application of an insulin solution in dogs resulted in the rise of plasma immunoreactive insulin and in dose-dependent hypoglycemia. The absorption of insulin from this site was found to be enhanced when insulin was dissolved in an acid medium. In addition, when an insulin preparation with some surfactant was used, the effectiveness of nasally administered insulin was 25 to 30 per cent of that achieved with intravenously administered insulin.

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Year:  1978        PMID： 25215     DOI： 10.2337/diab.27.3.296

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  20 in total

1.  Effects of pH and dose on nasal absorption of scopolamine hydrobromide in human subjects.

Authors:  S Ahmed; A P Sileno; J C deMeireles; R Dua; H K Pimplaskar; W J Xia; J Marinaro; E Langenback; F J Matos; L Putcha; V D Romeo; C R Behl
Journal:  Pharm Res       Date:  2000-08       Impact factor: 4.200

2.  The molecular weight dependence of nasal absorption: the effect of absorption enhancers.

Authors:  M D Donovan; G L Flynn; G L Amidon
Journal:  Pharm Res       Date:  1990-08       Impact factor: 4.200

3.  Influence of absorption promoters on pulmonary insulin bioactivity.

Authors:  T Mahesh Kumar; Ambikanandan Misra
Journal:  AAPS PharmSciTech       Date:  2003       Impact factor: 3.246

4.  Dodecylmaltoside-mediated nasal and ocular absorption of lyspro-insulin: independence of surfactant action from multimer dissociation.

Authors:  D J Pillion; S Hosmer; E Meezan
Journal:  Pharm Res       Date:  1998-10       Impact factor: 4.200

5.  Morpho-cytochemical and biochemical evidence for insulin absorption by the rat ileal epithelium.

Authors:  M Bendayan; E Ziv; R Ben-Sasson; H Bar-On; M Kidron
Journal:  Diabetologia       Date:  1990-04       Impact factor: 10.122

6.  Bile salt-fatty acid mixed micelles as nasal absorption promoters of peptides. II. In vivo nasal absorption of insulin in rats and effects of mixed micelles on the morphological integrity of the nasal mucosa.

Authors:  P Tengamnuay; A K Mitra
Journal:  Pharm Res       Date:  1990-04       Impact factor: 4.200

Review 7.  Intranasal drug delivery. Potential advantages and limitations from a clinical pharmacokinetic perspective.

Authors:  A E Pontiroli; A Calderara; G Pozza
Journal:  Clin Pharmacokinet       Date:  1989-11       Impact factor: 6.447

8.  The use of alpha-aminoboronic acid derivatives to stabilize peptide drugs during their intranasal absorption.

Authors:  M A Hussain; A B Shenvi; S M Rowe; E Shefter
Journal:  Pharm Res       Date:  1989-02       Impact factor: 4.200

9.  Absorption enhancement of intranasally administered insulin by sodium taurodihydrofusidate (STDHF) in rabbits and rats.

Authors:  M J Deurloo; W A Hermens; S G Romeyn; J C Verhoef; F W Merkus
Journal:  Pharm Res       Date:  1989-10       Impact factor: 4.200

10.  Biochemical and morpho-cytochemical evidence for the intestinal absorption of insulin in control and diabetic rats. Comparison between the effectiveness of duodenal and colon mucosa.

Authors:  M Bendayan; E Ziv; D Gingras; R Ben-Sasson; H Bar-On; M Kidron
Journal:  Diabetologia       Date:  1994-02       Impact factor: 10.122
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