Literature DB >> 2788271

The use of alpha-aminoboronic acid derivatives to stabilize peptide drugs during their intranasal absorption.

M A Hussain1, A B Shenvi, S M Rowe, E Shefter.   

Abstract

alpha-Aminoboronic acid derivatives, potent and reversible inhibitors of aminopeptidases, were tested nasally in situ in rats for stabilizing externally administered peptides. These inhibitors, at nanomolar concentrations, were found to inhibit greatly the degradation of the model peptide, leucine-enkephalin (Leu-enk) in the nasal perfusate. Enzyme inhibition was greater with boroleucine and borovaline than that observed with boroalanine. Boroleucine was more than 100 times more effective in enzyme inhibition than bestatin and more than 1000 times more effective than puromycin.

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Year:  1989        PMID： 2788271     DOI： 10.1023/a:1015949013644

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  13 in total

1.  Inhibition of aminopeptidase B and leucine aminopeptidase by bestatin and its stereoisomer.

Authors:  H Suda; T Aoyagi; T Takeuchi; H Umezawa
Journal:  Arch Biochem Biophys       Date:  1976-11       Impact factor: 4.013

2.  Nasal absorption of insulin in dogs.

Authors:  S Harai; T Ikenaga; T Matsuzawa
Journal:  Diabetes       Date:  1978-03       Impact factor: 9.461

3.  The hydrolysis of amino acyl-beta-naphthylamides by plasma aminopeptidases.

Authors:  J K McDonald; T J Reilly; S Ellis
Journal:  Biochem Biophys Res Commun       Date:  1964-06-01       Impact factor: 3.575

4.  2-phenylethaneboronic acid, a possible transition-state analog for chymotrypsin.

Authors:  K A Koehler; G E Lienhard
Journal:  Biochemistry       Date:  1971-06-22       Impact factor: 3.162

5.  New mucosal dosage form of insulin.

Authors:  M Ishida; Y Machida; N Nambu; T Nagai
Journal:  Chem Pharm Bull (Tokyo)       Date:  1981-03       Impact factor: 1.645

6.  alpha-Aminoboronic acid derivatives: effective inhibitors of aminopeptidases.

Authors:  A B Shenvi
Journal:  Biochemistry       Date:  1986-03-25       Impact factor: 3.162

7.  Vaginal absorption of a potent luteinizing hormone-releasing hormone analog (leuprolide) in rats I: absorption by various routes and absorption enhancement.

Authors:  H Okada; I Yamazaki; Y Ogawa; S Hirai; T Yashiki; H Mima
Journal:  J Pharm Sci       Date:  1982-12       Impact factor: 3.534

8.  Inhibition of serine proteases by arylboronic acids.

Authors:  M Philipp; M L Bender
Journal:  Proc Natl Acad Sci U S A       Date:  1971-02       Impact factor: 11.205

9.  Adjuvant effects of glyceryl esters of acetoacetic acid on rectal absorption of insulin and inulin in rabbits.

Authors:  T Nishihata; S Kim; S Morishita; A Kamada; N Yata; T Higuchi
Journal:  J Pharm Sci       Date:  1983-03       Impact factor: 3.534

10.  Insulin administered intranasally as an insulin-bile salt aerosol. Effectiveness and reproducibility in normal and diabetic subjects.

Authors:  A C Moses; G S Gordon; M C Carey; J S Flier
Journal:  Diabetes       Date:  1983-11       Impact factor: 9.461
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  6 in total

Review 1.  Transport of peptide and protein drugs across biological membranes.

Authors:  J C Verhoef; H E Boddé; A G de Boer; J A Bouwstra; H E Junginger; F W Merkus; D D Breimer
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1990 Apr-Jun       Impact factor: 2.441

Review 2.  Drug metabolism in the nasal mucosa.

Authors:  M A Sarkar
Journal:  Pharm Res       Date:  1992-01       Impact factor: 4.200

3.  A phosphinic acid dipeptide analogue to stabilize peptide drugs during their intranasal absorption.

Authors:  M A Hussain; M S Lim; K S Raghavan; N J Rogers; R Hidalgo; C A Kettner
Journal:  Pharm Res       Date:  1992-05       Impact factor: 4.200

4.  Effects of proteolytic enzyme inhibitors on the nasal absorption of vasopressin and an analogue.

Authors:  K Morimoto; H Yamaguchi; Y Iwakura; M Miyazaki; E Nakatani; T Iwamoto; Y Ohashi; Y Nakai
Journal:  Pharm Res       Date:  1991-09       Impact factor: 4.200

5.  Development and in vitro evaluation of systems to protect peptide drugs from aminopeptidase N.

Authors:  A Bernkop-Schnürch; M K Marschütz
Journal:  Pharm Res       Date:  1997-02       Impact factor: 4.200

6.  Cryptosporidium parvum metalloaminopeptidase inhibitors prevent in vitro excystation.

Authors:  P C Okhuysen; C L Chappell; C Kettner; C R Sterling
Journal:  Antimicrob Agents Chemother       Date:  1996-12       Impact factor: 5.191
  6 in total

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