Andrea Igoren Guaricci1, Teresa Arcadi2, Natale Daniele Brunetti3, Erica Maffei2, Deodata Montrone3, Chiara Martini3, Maria De Luca3, Fiorella De Rosa3, Domenico Cocco3, Massimo Midiri4, Filippo Cademartiri5, Luca Macarini6, Matteo Di Biase3, Gianluca Pontone7. 1. Cardiology Department, University of Foggia, "Ospedali Riuniti" Hospital, Foggia, Italy. Electronic address: andrea.guaricci@gmail.com. 2. Cardiovascular Radiology Unit, Division Giovanni XXIII Hospital, Monastier di Treviso, Italy. 3. Cardiology Department, University of Foggia, "Ospedali Riuniti" Hospital, Foggia, Italy. 4. Department of Radiology, DIBIMEF, University Hospital "P. Giaccone", University of Palermo, Palermo, Italy. 5. Cardiovascular Radiology Unit, Division Giovanni XXIII Hospital, Monastier di Treviso, Italy; Department of Radiology, Erasmus Medical Center University, Rotterdam, The Netherlands. 6. Department of Diagnostic Imaging, University of Foggia, "Ospedali Riuniti" Hospital, Foggia, Italy. 7. Centro Cardiologico Monzino, IRCCS, Milan, Italy.
Abstract
BACKGROUND: There is a growing evidence that carotid intima media thickness (CIMT) is associated with coronary artery disease (CAD) and it should be used as a predictor of atherosclerotic burden of coronary arteries. However, these studies have been performed by using invasive coronary angiography (ICA) and in high-risk patients for CAD. The purpose of this study was to evaluate the correlation between CIMT by ultrasound and coronary atherosclerosis in symptomatic intermediate risk patients by coronary computed tomography angiography (CCTA). METHODS: We enrolled 204 consecutive symptomatic patients (mean age: 61±10; men: 118) and intermediate risk for CAD. All patients underwent CIMT ultrasound evaluation and CCTA. Coronary artery calcium score (CACS), characteristics of plaques, severity of CAD, segment involvement score (SIS) and Gensini's score were assessed and compared with CIMT values. RESULTS: CIMT has been proved as an independent predictor of a number of coronary artery plaques, overall number of mixed and remodeled plaques, presence of obstructive CAD, high SIS and Gensini's score (HR 1.2, CI 1.05-1.42, p 0.01; HR 1.2, CI 1.01-1.41, p 0.03; HR 9.0, CI 1.37-59.7, p 0.02; HR 21.0, CI 2.40-184, p<0.01; HR 1.2, CI 1.08-1.42, p<0.01; HR 1.2, CI 1.08-1.42, p<0.01, respectively). A cut-off value>1.3 was associated with a better positive and negative predictive value (100% and 69%) to predict the combined endpoint of presence and mixed and/or remodeled coronary artery plaques. CONCLUSIONS: CIMT is an independent predictor of coronary atherosclerotic burden as detected by CCTA in symptomatic intermediate risk patients.
BACKGROUND: There is a growing evidence that carotid intima media thickness (CIMT) is associated with coronary artery disease (CAD) and it should be used as a predictor of atherosclerotic burden of coronary arteries. However, these studies have been performed by using invasive coronary angiography (ICA) and in high-risk patients for CAD. The purpose of this study was to evaluate the correlation between CIMT by ultrasound and coronary atherosclerosis in symptomatic intermediate risk patients by coronary computed tomography angiography (CCTA). METHODS: We enrolled 204 consecutive symptomatic patients (mean age: 61±10; men: 118) and intermediate risk for CAD. All patients underwent CIMT ultrasound evaluation and CCTA. Coronary artery calcium score (CACS), characteristics of plaques, severity of CAD, segment involvement score (SIS) and Gensini's score were assessed and compared with CIMT values. RESULTS:CIMT has been proved as an independent predictor of a number of coronary artery plaques, overall number of mixed and remodeled plaques, presence of obstructive CAD, high SIS and Gensini's score (HR 1.2, CI 1.05-1.42, p 0.01; HR 1.2, CI 1.01-1.41, p 0.03; HR 9.0, CI 1.37-59.7, p 0.02; HR 21.0, CI 2.40-184, p<0.01; HR 1.2, CI 1.08-1.42, p<0.01; HR 1.2, CI 1.08-1.42, p<0.01, respectively). A cut-off value>1.3 was associated with a better positive and negative predictive value (100% and 69%) to predict the combined endpoint of presence and mixed and/or remodeled coronary artery plaques. CONCLUSIONS:CIMT is an independent predictor of coronary atherosclerotic burden as detected by CCTA in symptomatic intermediate risk patients.
Authors: Carlos Henrique Reis Esselin Rassi; Timothy W Churchill; Carlos A Fernandes Tavares; Mateus Guimaraes Fahel; Fabricia P O Rassi; Augusto H Uchida; Bernardo L Wajchenberg; Antonio C Lerario; Edward Hulten; Khurram Nasir; Márcio S Bittencourt; Carlos Eduardo Rochitte; Ron Blankstein Journal: Cardiovasc Diabetol Date: 2016-02-09 Impact factor: 9.951
Authors: Andrea Igoren Guaricci; Delia De Santis; Mariangela Carbone; Giuseppe Muscogiuri; Marco Guglielmo; Andrea Baggiano; Gaetano Serviddio; Gianluca Pontone Journal: Biomed Res Int Date: 2018-01-15 Impact factor: 3.411
Authors: Francesca Baessato; Marco Guglielmo; Giuseppe Muscogiuri; Andrea Baggiano; Laura Fusini; Stefano Scafuri; Mario Babbaro; Rocco Mollace; Ada Collevecchio; Andrea I Guaricci; Gianluca Pontone Journal: Biomed Res Int Date: 2021-01-14 Impact factor: 3.411