Literature DB >> 25209429

Radical C-H functionalization of heteroarenes under electrochemical control.

Alexander G O'Brien1, Akinobu Maruyama, Yasuhide Inokuma, Makoto Fujita, Phil S Baran, Donna G Blackmond.   

Abstract

Electrochemical reactions are shown to be effective for the C-H functionalization of a number of heterocyclic substrates that are recalcitrant to conventional peroxide radical initiation conditions. Monitoring reaction progress under electrochemical conditions provides mechanistic insight into the C-H functionalization of a series of heterocycles of interest in medicinal chemistry.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  CH activation; electrochemistry; heterocycles; radical reactions; reaction mechanisms

Mesh：

Substances：

Year:  2014        PMID： 25209429      PMCID： PMC4214156          DOI： 10.1002/anie.201407948

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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