Hosein Mashhadinezhad1, Fariborz Samini1, Reza Zare1. 1. Hosein Mashhadinezhad MD, Fariborz Samini MD, Reza Zare MD, Department of Neurosurgery, Faculty of Medicine Trauma Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract
BACKGROUND: After cervical discectomy, autogenic bone is packed into the cage to increase the rate of union between adjacent vertebral bodies, but donor site-related complications can still occur. In this study we evaluate the use of hydroxyapatite granules as a substitute for autograft for interbody fusion. METHODS: From November 2008 to November 2011, 236 patients participated in this study. Peek cages were packed with autologous bone grafts taken from the iliac crest in 112 patients and hydroxyapatite (HA) granules in 124 patients. Patients were followed for 12 months. The patients' neurological signs, results, and complications were fully recorded throughout the procedure. Radiological imaging was done to assess the fusion rate and settling ratio. RESULTS: Formation of bony bridges at the third month was higher in the autograft group versus the granule group. However, there was no difference between both groups at the 12-month follow-up assessment. No difference (P> 0.05) was found regarding improvement in neurological deficit as well as radicular pain and recovery rate between the two groups. CONCLUSIONS: Interbody fusion cage containing HA granules proved to be an effective treatment for cervical spondylotic radiculopathy and/or myelopathy. Clinical and neurological outcome, radiographic measurement and fusion rate in cage containing HA are similar and competitive with autograft packed cages.
BACKGROUND: After cervical discectomy, autogenic bone is packed into the cage to increase the rate of union between adjacent vertebral bodies, but donor site-related complications can still occur. In this study we evaluate the use of hydroxyapatite granules as a substitute for autograft for interbody fusion. METHODS: From November 2008 to November 2011, 236 patients participated in this study. Peek cages were packed with autologous bone grafts taken from the iliac crest in 112 patients and hydroxyapatite (HA) granules in 124 patients. Patients were followed for 12 months. The patients' neurological signs, results, and complications were fully recorded throughout the procedure. Radiological imaging was done to assess the fusion rate and settling ratio. RESULTS: Formation of bony bridges at the third month was higher in the autograft group versus the granule group. However, there was no difference between both groups at the 12-month follow-up assessment. No difference (P> 0.05) was found regarding improvement in neurological deficit as well as radicular pain and recovery rate between the two groups. CONCLUSIONS: Interbody fusion cage containing HA granules proved to be an effective treatment for cervical spondylotic radiculopathy and/or myelopathy. Clinical and neurological outcome, radiographic measurement and fusion rate in cage containing HA are similar and competitive with autograft packed cages.
Entities:
Keywords:
Autograft; Cage; Hydroxyapatite granules; Interbody fusion; Settling ratio
Authors: Miroslav Vukić; Beverly C Walters; Ankica Radić; Ivana Jurjević; Sergej M Marasanov; Marjan Rozanković; Hrvoje Jednacak Journal: Coll Antropol Date: 2011-01
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