| Literature DB >> 25201988 |
Cornelius A Rietveld1, Tõnu Esko2, Gail Davies3, Tune H Pers4, Patrick Turley5, Beben Benyamin6, Christopher F Chabris7, Valur Emilsson8, Andrew D Johnson9, James J Lee10, Christiaan de Leeuw11, Riccardo E Marioni12, Sarah E Medland13, Michael B Miller14, Olga Rostapshova15, Sven J van der Lee16, Anna A E Vinkhuyzen6, Najaf Amin16, Dalton Conley17, Jaime Derringer18, Cornelia M van Duijn19, Rudolf Fehrmann20, Lude Franke20, Edward L Glaeser5, Narelle K Hansell21, Caroline Hayward22, William G Iacono14, Carla Ibrahim-Verbaas23, Vincent Jaddoe24, Juha Karjalainen20, David Laibson5, Paul Lichtenstein5, David C Liewald25, Patrik K E Magnusson26, Nicholas G Martin27, Matt McGue14, George McMahon28, Nancy L Pedersen26, Steven Pinker29, David J Porteous30, Danielle Posthuma31, Fernando Rivadeneira32, Blair H Smith33, John M Starr34, Henning Tiemeier35, Nicholas J Timpson36, Maciej Trzaskowski37, André G Uitterlinden32, Frank C Verhulst38, Mary E Ward28, Margaret J Wright21, George Davey Smith36, Ian J Deary3, Magnus Johannesson39, Robert Plomin37, Peter M Visscher40, Daniel J Benjamin41, David Cesarini42, Philipp D Koellinger43.
Abstract
We identify common genetic variants associated with cognitive performance using a two-stage approach, which we call the proxy-phenotype method. First, we conduct a genome-wide association study of educational attainment in a large sample (n = 106,736), which produces a set of 69 education-associated SNPs. Second, using independent samples (n = 24,189), we measure the association of these education-associated SNPs with cognitive performance. Three SNPs (rs1487441, rs7923609, and rs2721173) are significantly associated with cognitive performance after correction for multiple hypothesis testing. In an independent sample of older Americans (n = 8,652), we also show that a polygenic score derived from the education-associated SNPs is associated with memory and absence of dementia. Convergent evidence from a set of bioinformatics analyses implicates four specific genes (KNCMA1, NRXN1, POU2F3, and SCRT). All of these genes are associated with a particular neurotransmitter pathway involved in synaptic plasticity, the main cellular mechanism for learning and memory.Entities:
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Year: 2014 PMID： 25201988 PMCID： PMC4183313 DOI： 10.1073/pnas.1404623111
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205