Literature DB >> 30552033

In vitro activity of EDTA and TOL-463 against Neisseria gonorrhoeae.

Evelyn E Nash1, Tara C Henning2, Cau D Pham2, Kevin Pettus2, Samera Sharpe2, Ellen N Kersh2.   

Abstract

Neisseria gonorrhoeae quickly develops drug resistance. Time-kill curves revealed that EDTA and TOL-463 inhibit growth similar to penicillin, ciprofloxacin, and azithromycin. Furthermore, synergistic and additive antimicrobial interactions occurred when EDTA and TOL-463 were combined with penicillin or azithromycin, respectively, suggesting that further investigations into these unconventional antimicrobials may be advantageous.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Antimicrobial resistance; Boric acid; Broth microdilution; EDTA; Neisseria gonorrhoeae

Mesh：

Substances：

Year:  2018        PMID： 30552033      PMCID： PMC6519449          DOI： 10.1016/j.diagmicrobio.2018.10.021

Source DB:  PubMed          Journal:  Diagn Microbiol Infect Dis        ISSN： 0732-8893            Impact factor:   2.803


  18 in total

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2.  Antimicrobial Activity of a Vaginal Gel Formulation: Considerations Related to Vaginal Infection and Dysbiosis.

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