Literature DB >> 25198046

Atypical transforming growth factor-β signaling in the hypothalamus is linked to diabetes.

Eliana P Araujo1, Claudio T de Souza2, Licio A Velloso1.   

Abstract

Aging and a high-fat diet are predisposing factors for type 2 diabetes. A study in mice suggests that dietary fat and aging lead to atypical transforming growth factor-β1 signaling in the hypothalamus, which disturbs whole-body glucose regulation.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25198046     DOI： 10.1038/nm.3673

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  15 in total

1.  Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus.

Authors:  Cláudio T De Souza; Eliana P Araujo; Silvana Bordin; Rika Ashimine; Ricardo L Zollner; Antonio C Boschero; Mário J A Saad; Lício A Velloso
Journal:  Endocrinology       Date:  2005-07-07       Impact factor: 4.736

Review 2.  Stress granules: the Tao of RNA triage.

Authors:  Paul Anderson; Nancy Kedersha
Journal:  Trends Biochem Sci       Date:  2008-03       Impact factor: 13.807

3.  Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling.

Authors:  Hariom Yadav; Celia Quijano; Anil K Kamaraju; Oksana Gavrilova; Rana Malek; Weiping Chen; Patricia Zerfas; Duan Zhigang; Elizabeth C Wright; Christina Stuelten; Peter Sun; Scott Lonning; Monica Skarulis; Anne E Sumner; Toren Finkel; Sushil G Rane
Journal:  Cell Metab       Date:  2011-07-06       Impact factor: 27.287

4.  Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice.

Authors:  F N Ziyadeh; B B Hoffman; D C Han; M C Iglesias-De La Cruz; S W Hong; M Isono; S Chen; T A McGowan; K Sharma
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-05       Impact factor: 11.205

5.  Inhibition of the ubiquitin-proteasome system induces stress granule formation.

Authors:  Rachid Mazroui; Sergio Di Marco; Randal J Kaufman; Imed-Eddine Gallouzi
Journal:  Mol Biol Cell       Date:  2007-05-02       Impact factor: 4.138

Review 6.  Targeting the TGFβ signalling pathway in disease.

Authors:  Rosemary J Akhurst; Akiko Hata
Journal:  Nat Rev Drug Discov       Date:  2012-09-24       Impact factor: 84.694

7.  Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease.

Authors:  M M Shull; I Ormsby; A B Kier; S Pawlowski; R J Diebold; M Yin; R Allen; C Sidman; G Proetzel; D Calvin
Journal:  Nature       Date:  1992-10-22       Impact factor: 49.962

Review 8.  CNS regulation of glucose homeostasis.

Authors:  Carol K L Lam; Madhu Chari; Tony K T Lam
Journal:  Physiology (Bethesda)       Date:  2009-06

9.  Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response.

Authors:  Jingqi Yan; Hai Zhang; Ye Yin; Juxue Li; Yizhe Tang; Sudarshana Purkayastha; Lianxi Li; Dongsheng Cai
Journal:  Nat Med       Date:  2014-08-03       Impact factor: 53.440

Review 10.  'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation.

Authors:  Yisong Y Wan; Richard A Flavell
Journal:  Immunol Rev       Date:  2007-12       Impact factor: 12.988
View more
  6 in total

Review 1.  The pathophysiology of defective proteostasis in the hypothalamus - from obesity to ageing.

Authors:  Cláudia Cavadas; Célia A Aveleira; Gabriela F P Souza; Lício A Velloso
Journal:  Nat Rev Endocrinol       Date:  2016-07-08       Impact factor: 43.330

Review 2.  Hypothalamic Inflammation as a Potential Pathophysiologic Basis for the Heterogeneity of Clinical, Hormonal, and Metabolic Presentation in PCOS.

Authors:  Danai Barlampa; Maria Sotiria Bompoula; Alexandra Bargiota; Sophia Kalantaridou; George Mastorakos; Georgios Valsamakis
Journal:  Nutrients       Date:  2021-02-05       Impact factor: 5.717

Review 3.  Hypothalamic neuronal cellular and subcellular abnormalities in experimental obesity.

Authors:  Daniela S Razolli; Alexandre Moura-Assis; Bruna Bombassaro; Licio A Velloso
Journal:  Int J Obes (Lond)       Date:  2019-09-23       Impact factor: 5.095

4.  miR-145-5p Inhibits Vascular Smooth Muscle Cells (VSMCs) Proliferation and Migration by Dysregulating the Transforming Growth Factor-b Signaling Cascade.

Authors:  Li Li; Dingbiao Mao; Cheng Li; Ming Li
Journal:  Med Sci Monit       Date:  2018-07-15

5.  TLR4-interactor with leucine-rich repeats (TRIL) is involved in diet-induced hypothalamic inflammation.

Authors:  Alexandre Moura-Assis; Pedro A S Nogueira; Jose C de-Lima-Junior; Fernando M Simabuco; Joana M Gaspar; Jose Donato; Licio A Velloso
Journal:  Sci Rep       Date:  2021-09-09       Impact factor: 4.379

Review 6.  Anti-Inflammatory Nutrients and Obesity-Associated Metabolic-Inflammation: State of the Art and Future Direction.

Authors:  Giuseppe Grosso; Daniela Laudisio; Evelyn Frias-Toral; Luigi Barrea; Giovanna Muscogiuri; Silvia Savastano; Annamaria Colao
Journal:  Nutrients       Date:  2022-03-08       Impact factor: 5.717
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.