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Literature DB >> 17979848

'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation.

Abstract

Transforming growth factor-beta (TGF-beta) and forkhead box p3-expressing T-regulatory (Treg) cells are critical in maintaining self-tolerance and immune homeostasis. The immune suppressive functions of TGF-beta and Treg cells are widely acknowledged and extensively studied. Nonetheless, recent studies revealed the positive roles of TGF-beta and Treg cells in shaping the immune system and the inflammatory responses. This review discusses our and other's efforts in understanding the negative (Yin) as well as the positive (Yang) roles for TGF-beta and Treg cells in immune regulation.

Entities: Chemical

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Year: 2007 PMID： 17979848 PMCID： PMC2614905 DOI： 10.1111/j.1600-065X.2007.00565.x

Source DB: PubMed Journal: Immunol Rev ISSN： 0105-2896 Impact factor: 12.988

161 in total

1. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength.

Authors: Jackson G Egen; James P Allison
Journal: Immunity Date: 2002-01 Impact factor: 31.745

2. IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells.

Authors: Pedro L Vieira; Jillian R Christensen; Sophie Minaee; Emma J O'Neill; Franck J Barrat; André Boonstra; Thomas Barthlott; Brigitta Stockinger; David C Wraith; Anne O'Garra
Journal: J Immunol Date: 2004-05-15 Impact factor: 5.422

3. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.

Authors: Estelle Bettelli; Yijun Carrier; Wenda Gao; Thomas Korn; Terry B Strom; Mohamed Oukka; Howard L Weiner; Vijay K Kuchroo
Journal: Nature Date: 2006-04-30 Impact factor: 49.962

Review 4. Making sense of latent TGFbeta activation.

Authors: Justin P Annes; John S Munger; Daniel B Rifkin
Journal: J Cell Sci Date: 2003-01-15 Impact factor: 5.285

5. TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet.

Authors: Jack T Lin; Stacey L Martin; Luxi Xia; James D Gorham
Journal: J Immunol Date: 2005-05-15 Impact factor: 5.422

6. Regulation of lymphokine-activated killer activity and pore-forming protein gene expression in human peripheral blood CD8+ T lymphocytes. Inhibition by transforming growth factor-beta.

Authors: M J Smyth; S L Strobl; H A Young; J R Ortaldo; A C Ochoa
Journal: J Immunol Date: 1991-05-15 Impact factor: 5.422

7. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.

Authors: Marc Veldhoen; Richard J Hocking; Christopher J Atkins; Richard M Locksley; Brigitta Stockinger
Journal: Immunity Date: 2006-02 Impact factor: 31.745

Review 8. Smad-dependent and Smad-independent pathways in TGF-beta family signalling.

Authors: Rik Derynck; Ying E Zhang
Journal: Nature Date: 2003-10-09 Impact factor: 49.962

9. Human Smad3 and Smad4 are sequence-specific transcription activators.

Authors: L Zawel; J L Dai; P Buckhaults; S Zhou; K W Kinzler; B Vogelstein; S E Kern
Journal: Mol Cell Date: 1998-03 Impact factor: 17.970

10. The role of transforming growth factor beta in the generation of suppression: an interaction between CD8+ T and NK cells.

Authors: J D Gray; M Hirokawa; D A Horwitz
Journal: J Exp Med Date: 1994-11-01 Impact factor: 14.307

144 in total

1. IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma.

Authors: Qiaoling Liang; Lei Guo; Shaila Gogate; Zunayet Karim; Arezoo Hanifi; Donald Y Leung; Magdalena M Gorska; Rafeul Alam
Journal: J Immunol Date: 2010-10-06 Impact factor: 5.422

2. Upregulation of miR-142-3p in peripheral blood mononuclear cells of operationally tolerant patients with a renal transplant.

Authors: Richard Danger; Annaïck Pallier; Magali Giral; Marc Martínez-Llordella; Juan José Lozano; Nicolas Degauque; Alberto Sanchez-Fueyo; Jean-Paul Soulillou; Sophie Brouard
Journal: J Am Soc Nephrol Date: 2012-01-26 Impact factor: 10.121

Review 3. Emerging cytokine networks in colorectal cancer.

Authors: Nathan R West; Sarah McCuaig; Fanny Franchini; Fiona Powrie
Journal: Nat Rev Immunol Date: 2015-09-11 Impact factor: 53.106

4. TCR signaling intensity controls CD8+ T cell responsiveness to TGF-β.

Authors: Vidhyalakshmi Arumugam; Theresa Bluemn; Erin Wesley; Amanda M Schmidt; Taku Kambayashi; Subramaniam Malarkannan; Matthew J Riese
Journal: J Leukoc Biol Date: 2015-07-07 Impact factor: 4.962

5. High-protein diet improves sensitivity to cholecystokinin and shifts the cecal microbiome without altering brain inflammation in diet-induced obesity in rats.

Authors: Lixin Wang; Jonathan P Jacobs; Venu Lagishetty; Pu-Qing Yuan; Shuping V Wu; Mulugeta Million; Joseph R Reeve; Joseph R Pisegna; Yvette Taché
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2017-07-19 Impact factor: 3.619

6. IL-17-producing human peripheral regulatory T cells retain suppressive function.

Authors: Gaëlle Beriou; Cristina M Costantino; Charles W Ashley; Li Yang; Vijay K Kuchroo; Clare Baecher-Allan; David A Hafler
Journal: Blood Date: 2009-01-26 Impact factor: 22.113

Review 7. Megakaryocytes as immune cells.

Authors: Pierre Cunin; Peter A Nigrovic
Journal: J Leukoc Biol Date: 2019-01-15 Impact factor: 4.962