Literature DB >> 25197148

An Enantioselective Synthesis of a MEM-Protected Aetheramide A Derivative.

Arun K Ghosh1, Kalapala Venkateswara Rao1, Siddhartha Akasapu1.   

Abstract

Aetheramides A and B are very potent anti-HIV agents. An enantioselective synthesis of a MEM-protected aetheramide A derivative is described. The synthesis was accomplished in a convergent and stereoselective manner. The key reactions involved asymmetric dihydroxylation, asymmetric allylation, asymmetric syn-aldol reactions and asymmetric hydrogenation.

Entities:  

Keywords:  Aetheramides; Anti-HIV; Anticancer; Asymmetric synthesis; Natural product

Year:  2014        PMID： 25197148      PMCID： PMC4153992          DOI： 10.1016/j.tetlet.2014.07.077

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  8 in total

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Authors:  Ronald Garcia; Klaus Gerth; Marc Stadler; Irineo J Dogma; Rolf Müller
Journal:  Mol Phylogenet Evol       Date:  2010-08-31       Impact factor: 4.286

2.  A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide.

Authors:  K C Nicolaou; Anthony A Estrada; Mark Zak; Sang Hyup Lee; Brian S Safina
Journal:  Angew Chem Int Ed Engl       Date:  2005-02-18       Impact factor: 15.336

Review 3.  Natural products as sources of new drugs over the 30 years from 1981 to 2010.

Authors:  David J Newman; Gordon M Cragg
Journal:  J Nat Prod       Date:  2012-02-08       Impact factor: 4.050

Review 4.  Marine natural products with anti-HIV activities in the last decade.

Authors:  Xuefeng Zhou; Juan Liu; Bin Yang; Xiuping Lin; Xian-Wen Yang; Yonghong Liu
Journal:  Curr Med Chem       Date:  2013       Impact factor: 4.530

5.  Aetheramides A and B, potent HIV-inhibitory depsipeptides from a myxobacterium of the new genus "Aetherobacter".

Authors:  Alberto Plaza; Ronald Garcia; Giuseppe Bifulco; Javier Pablo Martinez; Stephan Hüttel; Florenz Sasse; Andreas Meyerhans; Marc Stadler; Rolf Müller
Journal:  Org Lett       Date:  2012-05-22       Impact factor: 6.005

6.  Synthetic studies on macrolactin A: construction of C4-C24 fragment.

Authors:  Marie Georgy; Philippe Lesot; Jean-Marc Campagne
Journal:  J Org Chem       Date:  2007-04-03       Impact factor: 4.354

7.  Total synthesis and biological evaluation of grassypeptolide A.

Authors:  Hui Liu; Yuqing Liu; Zhuo Wang; Xiangyou Xing; Anita R Maguire; Hendrik Luesch; Hui Zhang; Zhengshuang Xu; Tao Ye
Journal:  Chemistry       Date:  2013-03-27       Impact factor: 5.236

Review 8.  Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV.

Authors:  Erik De Clercq
Journal:  Int J Antimicrob Agents       Date:  2008-12-23       Impact factor: 5.283
  8 in total

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