Literature DB >> 22616796

Aetheramides A and B, potent HIV-inhibitory depsipeptides from a myxobacterium of the new genus "Aetherobacter".

Alberto Plaza1, Ronald Garcia, Giuseppe Bifulco, Javier Pablo Martinez, Stephan Hüttel, Florenz Sasse, Andreas Meyerhans, Marc Stadler, Rolf Müller.   

Abstract

Aetheramides are structurally distinctive cyclic peptides isolated from a novel myxobacterial genus proposed to be termed "Aetherobacter". The structures were solved by a combination of NMR analyses, quantum mechanical calculations, and chemical derivatizations. Aetheramides which contain a unique polyketide moiety and two amino acid residues potently inhibited HIV-1 infection with IC(50) values of ~0.015 μM. Furthermore aetheramides showed cytostatic activity against human colon carcinoma (HCT-116) cells with IC(50) values of 0.11 μM.

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Year:  2012        PMID： 22616796     DOI： 10.1021/ol3011002

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  13 in total

Review 1.  Myxobacteria and their products: current trends and future perspectives in industrial applications.

Authors:  Akansha Shrivastava; Rakesh Kumar Sharma
Journal:  Folia Microbiol (Praha)       Date:  2021-05-31       Impact factor: 2.099

2.  Configurational assignments of conformationally restricted bis-monoterpene hydroquinones: utility in exploration of endangered plants.

Authors:  Joonseok Oh; John J Bowling; Yike Zou; Amar G Chittiboyina; Robert J Doerksen; Daneel Ferreira; Theodor D Leininger; Mark T Hamann
Journal:  Biochim Biophys Acta       Date:  2013-04-26

3.  Genome Analysis of the Fruiting Body-Forming Myxobacterium Chondromyces crocatus Reveals High Potential for Natural Product Biosynthesis.

Authors:  Nestor Zaburannyi; Boyke Bunk; Josef Maier; Jörg Overmann; Rolf Müller
Journal:  Appl Environ Microbiol       Date:  2016-01-15       Impact factor: 4.792

4.  An Enantioselective Synthesis of a MEM-Protected Aetheramide A Derivative.

Authors:  Arun K Ghosh; Kalapala Venkateswara Rao; Siddhartha Akasapu
Journal:  Tetrahedron Lett       Date:  2014-09-10       Impact factor: 2.415

5.  Structure and biosynthesis of sorangipyranone - a new γ-dihydropyrone from the myxobacterial strain MSr12020.

Authors:  Dorothy A Okoth; Joachim J Hug; Attila Mándi; Tibor Kurtán; Ronald Garcia; Rolf Müller
Journal:  J Ind Microbiol Biotechnol       Date:  2021-06-04       Impact factor: 4.258

6.  Myxobacteria in high moor and fen: An astonishing diversity in a neglected extreme habitat.

Authors:  Kathrin I Mohr; Tanja Zindler; Joachim Wink; Elke Wilharm; Marc Stadler
Journal:  Microbiologyopen       Date:  2017-04-11       Impact factor: 3.139

7.  Six Heterocyclic Metabolites from the Myxobacterium Labilithrix luteola.

Authors:  Lucky S Mulwa; Rolf Jansen; Dimas F Praditya; Kathrin I Mohr; Joachim Wink; Eike Steinmann; Marc Stadler
Journal:  Molecules       Date:  2018-02-28       Impact factor: 4.411

8.  2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene-Nucleoside.

Authors:  Dorothy A Okoth; Joachim J Hug; Ronald Garcia; Cathrin Spröer; Jörg Overmann; Rolf Müller
Journal:  Molecules       Date:  2020-06-09       Impact factor: 4.411

9.  Comparison of myxobacterial diversity and evaluation of isolation success in two niches: Kiritimati Island and German compost.

Authors:  Kathrin I Mohr; Marc Stechling; Joachim Wink; Elke Wilharm; Marc Stadler
Journal:  Microbiologyopen       Date:  2015-12-15       Impact factor: 3.139

10.  Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria.

Authors:  Thomas Hoffmann; Daniel Krug; Nisa Bozkurt; Srikanth Duddela; Rolf Jansen; Ronald Garcia; Klaus Gerth; Heinrich Steinmetz; Rolf Müller
Journal:  Nat Commun       Date:  2018-02-23       Impact factor: 14.919
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