Literature DB >> 25192705

No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk.

Mengmeng Du1, Xuehong Zhang2, Michael Hoffmeister3, Robert E Schoen4, John A Baron5, Sonja I Berndt6, Hermann Brenner7, Christopher S Carlson8, Graham Casey9, Andrew T Chan10, Keith R Curtis8, David Duggan11, W James Gauderman12, Edward L Giovannucci13, Jian Gong8, Tabitha A Harrison8, Richard B Hayes14, Brian E Henderson12, John L Hopper15, Li Hsu8, Thomas J Hudson16, Carolyn M Hutter17, Mark A Jenkins15, Shuo Jiao8, Jonathan M Kocarnik18, Laurence N Kolonel19, Loic Le Marchand19, Yi Lin8, Polly A Newcomb18, Anja Rudolph20, Daniela Seminara21, Mark D Thornquist8, Cornelia M Ulrich22, Emily White18, Kana Wu23, Brent W Zanke24, Peter T Campbell25, Martha L Slattery26, Ulrike Peters18, Jenny Chang-Claude21, John D Potter27.   

Abstract

BACKGROUND: Calcium intake may reduce risk of colorectal cancer, but the mechanisms remain unclear. Studies of interaction between calcium intake and SNPs in calcium-related pathways have yielded inconsistent results.
METHODS: To identify gene-calcium interactions, we tested interactions between approximately 2.7 million SNPs across the genome with self-reported calcium intake (from dietary or supplemental sources) in 9,006 colorectal cancer cases and 9,503 controls of European ancestry. To test for multiplicative interactions, we used multivariable logistic regression and defined statistical significance using the conventional genome-wide α = 5E-08.
RESULTS: After accounting for multiple comparisons, there were no statistically significant SNP interactions with total, dietary, or supplemental calcium intake.
CONCLUSIONS: We found no evidence of SNP interactions with calcium intake for colorectal cancer risk in a large population of 18,509 individuals. IMPACT: These results suggest that in genome-wide analysis common genetic variants do not strongly modify the association between calcium intake and colorectal cancer in European populations. ©2014 American Association for Cancer Research.

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Year:  2014        PMID: 25192705      PMCID: PMC4257872          DOI: 10.1158/1055-9965.EPI-14-0893

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN: 1055-9965            Impact factor:   4.254


  8 in total

1.  Characterization of gene-environment interactions for colorectal cancer susceptibility loci.

Authors:  Carolyn M Hutter; Jenny Chang-Claude; Martha L Slattery; Bethann M Pflugeisen; Yi Lin; David Duggan; Hongmei Nan; Mathieu Lemire; Jagadish Rangrej; Jane C Figueiredo; Shuo Jiao; Tabitha A Harrison; Yan Liu; Lin S Chen; Deanna L Stelling; Greg S Warnick; Michael Hoffmeister; Sébastien Küry; Charles S Fuchs; Edward Giovannucci; Aditi Hazra; Peter Kraft; David J Hunter; Steven Gallinger; Brent W Zanke; Hermann Brenner; Bernd Frank; Jing Ma; Cornelia M Ulrich; Emily White; Polly A Newcomb; Charles Kooperberg; Andrea Z LaCroix; Ross L Prentice; Rebecca D Jackson; Robert E Schoen; Stephen J Chanock; Sonja I Berndt; Richard B Hayes; Bette J Caan; John D Potter; Li Hsu; Stéphane Bézieau; Andrew T Chan; Thomas J Hudson; Ulrike Peters
Journal:  Cancer Res       Date:  2012-02-24       Impact factor: 12.701

2.  Genotype-environment interactions in microsatellite stable/microsatellite instability-low colorectal cancer: results from a genome-wide association study.

Authors:  Jane C Figueiredo; Juan Pablo Lewinger; Chi Song; Peter T Campbell; David V Conti; Christopher K Edlund; Dave J Duggan; Jagadish Rangrej; Mathieu Lemire; Thomas Hudson; Brent Zanke; Michelle Cotterchio; Steven Gallinger; Mark Jenkins; John Hopper; Robert Haile; Polly Newcomb; John Potter; John A Baron; Loic Le Marchand; Graham Casey
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2011-02-25       Impact factor: 4.254

3.  Dairy foods, calcium, and colorectal cancer: a pooled analysis of 10 cohort studies.

Authors:  Eunyoung Cho; Stephanie A Smith-Warner; Donna Spiegelman; W Lawrence Beeson; Piet A van den Brandt; Graham A Colditz; Aaron R Folsom; Gary E Fraser; Jo L Freudenheim; Edward Giovannucci; R Alexandra Goldbohm; Saxon Graham; Anthony B Miller; Pirjo Pietinen; John D Potter; Thomas E Rohan; Paul Terry; Paolo Toniolo; Mikko J Virtanen; Walter C Willett; Alicja Wolk; Kana Wu; Shiaw-Shyuan Yaun; Anne Zeleniuch-Jacquotte; David J Hunter
Journal:  J Natl Cancer Inst       Date:  2004-07-07       Impact factor: 13.506

Review 4.  Vitamin D gene pathway polymorphisms and risk of colorectal, breast, and prostate cancer.

Authors:  Marjorie L McCullough; Roberd M Bostick; Tinisha L Mayo
Journal:  Annu Rev Nutr       Date:  2009       Impact factor: 11.848

5.  Genetic variation in calcium-sensing receptor and risk for colon cancer.

Authors:  Linda M Dong; Cornelia M Ulrich; Li Hsu; David J Duggan; Debbie S Benitez; Emily White; Martha L Slattery; Bette J Caan; John D Potter; Ulrike Peters
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2008-10       Impact factor: 4.254

Review 6.  Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.

Authors:  Ulrike Peters; Shuo Jiao; Fredrick R Schumacher; Carolyn M Hutter; Aaron K Aragaki; John A Baron; Sonja I Berndt; Stéphane Bézieau; Hermann Brenner; Katja Butterbach; Bette J Caan; Peter T Campbell; Christopher S Carlson; Graham Casey; Andrew T Chan; Jenny Chang-Claude; Stephen J Chanock; Lin S Chen; Gerhard A Coetzee; Simon G Coetzee; David V Conti; Keith R Curtis; David Duggan; Todd Edwards; Charles S Fuchs; Steven Gallinger; Edward L Giovannucci; Stephanie M Gogarten; Stephen B Gruber; Robert W Haile; Tabitha A Harrison; Richard B Hayes; Brian E Henderson; Michael Hoffmeister; John L Hopper; Thomas J Hudson; David J Hunter; Rebecca D Jackson; Sun Ha Jee; Mark A Jenkins; Wei-Hua Jia; Laurence N Kolonel; Charles Kooperberg; Sébastien Küry; Andrea Z Lacroix; Cathy C Laurie; Cecelia A Laurie; Loic Le Marchand; Mathieu Lemire; David Levine; Noralane M Lindor; Yan Liu; Jing Ma; Karen W Makar; Keitaro Matsuo; Polly A Newcomb; John D Potter; Ross L Prentice; Conghui Qu; Thomas Rohan; Stephanie A Rosse; Robert E Schoen; Daniela Seminara; Martha Shrubsole; Xiao-Ou Shu; Martha L Slattery; Darin Taverna; Stephen N Thibodeau; Cornelia M Ulrich; Emily White; Yongbing Xiang; Brent W Zanke; Yi-Xin Zeng; Ben Zhang; Wei Zheng; Li Hsu
Journal:  Gastroenterology       Date:  2012-12-22       Impact factor: 22.682

7.  Calcium intake and colorectal cancer risk: dose-response meta-analysis of prospective observational studies.

Authors:  NaNa Keum; Dagfinn Aune; Darren C Greenwood; Woong Ju; Edward L Giovannucci
Journal:  Int J Cancer       Date:  2014-03-29       Impact factor: 7.396

8.  Genome-wide diet-gene interaction analyses for risk of colorectal cancer.

Authors:  Jane C Figueiredo; Li Hsu; Carolyn M Hutter; Yi Lin; Peter T Campbell; John A Baron; Sonja I Berndt; Shuo Jiao; Graham Casey; Barbara Fortini; Andrew T Chan; Michelle Cotterchio; Mathieu Lemire; Steven Gallinger; Tabitha A Harrison; Loic Le Marchand; Polly A Newcomb; Martha L Slattery; Bette J Caan; Christopher S Carlson; Brent W Zanke; Stephanie A Rosse; Hermann Brenner; Edward L Giovannucci; Kana Wu; Jenny Chang-Claude; Stephen J Chanock; Keith R Curtis; David Duggan; Jian Gong; Robert W Haile; Richard B Hayes; Michael Hoffmeister; John L Hopper; Mark A Jenkins; Laurence N Kolonel; Conghui Qu; Anja Rudolph; Robert E Schoen; Fredrick R Schumacher; Daniela Seminara; Deanna L Stelling; Stephen N Thibodeau; Mark Thornquist; Greg S Warnick; Brian E Henderson; Cornelia M Ulrich; W James Gauderman; John D Potter; Emily White; Ulrike Peters
Journal:  PLoS Genet       Date:  2014-04-17       Impact factor: 5.917

  8 in total
  6 in total

Review 1.  Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies.

Authors:  Chirag J Patel; Jacqueline Kerr; Duncan C Thomas; Bhramar Mukherjee; Beate Ritz; Nilanjan Chatterjee; Marta Jankowska; Juliette Madan; Margaret R Karagas; Kimberly A McAllister; Leah E Mechanic; M Daniele Fallin; Christine Ladd-Acosta; Ian A Blair; Susan L Teitelbaum; Christopher I Amos
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2017-07-14       Impact factor: 4.254

2.  Gene-diet interactions and their impact on colorectal cancer risk.

Authors:  Elizabeth D Kantor; Edward L Giovannucci
Journal:  Curr Nutr Rep       Date:  2015-03

Review 3.  Nature, Nurture, and Cancer Risks: Genetic and Nutritional Contributions to Cancer.

Authors:  Evropi Theodoratou; Maria Timofeeva; Xue Li; Xiangrui Meng; John P A Ioannidis
Journal:  Annu Rev Nutr       Date:  2017-08-21       Impact factor: 11.848

Review 4.  Review of the Gene-Environment Interaction Literature in Cancer: What Do We Know?

Authors:  Naoko I Simonds; Armen A Ghazarian; Camilla B Pimentel; Sheri D Schully; Gary L Ellison; Elizabeth M Gillanders; Leah E Mechanic
Journal:  Genet Epidemiol       Date:  2016-04-07       Impact factor: 2.135

Review 5.  Gene-environment interactions and colorectal cancer risk: An umbrella review of systematic reviews and meta-analyses of observational studies.

Authors:  Tian Yang; Xue Li; Zahra Montazeri; Julian Little; Susan M Farrington; John P A Ioannidis; Malcolm G Dunlop; Harry Campbell; Maria Timofeeva; Evropi Theodoratou
Journal:  Int J Cancer       Date:  2019-01-16       Impact factor: 7.396

6.  Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence.

Authors:  Gang Liu; Bhramar Mukherjee; Seunggeun Lee; Alice W Lee; Anna H Wu; Elisa V Bandera; Allan Jensen; Mary Anne Rossing; Kirsten B Moysich; Jenny Chang-Claude; Jennifer A Doherty; Aleksandra Gentry-Maharaj; Lambertus Kiemeney; Simon A Gayther; Francesmary Modugno; Leon Massuger; Ellen L Goode; Brooke L Fridley; Kathryn L Terry; Daniel W Cramer; Susan J Ramus; Hoda Anton-Culver; Argyrios Ziogas; Jonathan P Tyrer; Joellen M Schildkraut; Susanne K Kjaer; Penelope M Webb; Roberta B Ness; Usha Menon; Andrew Berchuck; Paul D Pharoah; Harvey Risch; Celeste Leigh Pearce
Journal:  Am J Epidemiol       Date:  2018-02-01       Impact factor: 4.897

  6 in total

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