Varalakshmi Desai1, Namburi Rajendra Prasad2, Suchitra Musturu Manohar3, Alok Sachan4, Srinivasa Rao Pemmaraju Venkata Lakshmi Narasimha5, Aparna Rajeshwar Rao Bitla3. 1. Post graduate, Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences , Tirupati, (A.P), India . 2. Resident, Department of Endocrinology, Narayana Medical College , Nellore, India . 3. Associate Professor, Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences , Tirupati, (A.P), India . 4. Professor and Head, Department of Endocrinology and Metabolism, Sri Venkateswara Institute of Medical Sciences , Tirupati, (A.P), India . 5. Professor and Head, Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences , Tirupati, (A.P), India .
Abstract
BACKGROUND: Polycystic ovarian syndrome (PCOS) is one of the most common endocrine diseases of women. Oxidative stress is an important component of the cardio-metabolic risk seen in these women. Oxidative stress has been reported in obese PCOS women. This study is taken up to study oxidative stress in non-obese PCOS women. MATERIALS AND METHODS: Twenty five non-obese women with PCOS attending the Endocrinology outpatient Department of Sri Venkateswara Institute of Medical Sciences, Tirupati, India along with 25 healthy BMI matched controls were included in the study. The changes in the lipid peroxidation products (MDA), and total anti oxidant capacity (FRAP) as an index of anti oxidant status along with fasting glucose, insulin and uric acid levels were measured in both groups. Insulin resistance was evaluated by using homeostasis model assessment for insulin resistance [HOMA-IR)= [FPG (mg/dl) × insulin (mIU/L)]/ 405] in both groups. RESULTS: Serum MDA and uric acid levels were increased in the study group compared with controls and FRAP levels were decreased in the study group compared to controls though statistically insignificant. CONCLUSION: Oxidative stress is also present in non-obese women with PCOS. Oxidative stress further increases the CVD risk in these women.Correcting oxidative stress with antioxidants along with monitoring the antioxidant status using a simple assay like FRAP could have a beneficial effect on oxidative stress induced insulin resistance and hyperandrogenism seen in these women.
BACKGROUND:Polycystic ovarian syndrome (PCOS) is one of the most common endocrine diseases of women. Oxidative stress is an important component of the cardio-metabolic risk seen in these women. Oxidative stress has been reported in obese PCOSwomen. This study is taken up to study oxidative stress in non-obese PCOSwomen. MATERIALS AND METHODS: Twenty five non-obesewomen with PCOS attending the Endocrinology outpatient Department of Sri Venkateswara Institute of Medical Sciences, Tirupati, India along with 25 healthy BMI matched controls were included in the study. The changes in the lipid peroxidation products (MDA), and total anti oxidant capacity (FRAP) as an index of anti oxidant status along with fasting glucose, insulin and uric acid levels were measured in both groups. Insulin resistance was evaluated by using homeostasis model assessment for insulin resistance [HOMA-IR)= [FPG (mg/dl) × insulin (mIU/L)]/ 405] in both groups. RESULTS: Serum MDA and uric acid levels were increased in the study group compared with controls and FRAP levels were decreased in the study group compared to controls though statistically insignificant. CONCLUSION: Oxidative stress is also present in non-obesewomen with PCOS. Oxidative stress further increases the CVD risk in these women.Correcting oxidative stress with antioxidants along with monitoring the antioxidant status using a simple assay like FRAP could have a beneficial effect on oxidative stress induced insulin resistance and hyperandrogenism seen in these women.
Authors: Sarah A Blair; Tommy Kyaw-Tun; Ian S Young; Niamh A Phelan; James Gibney; Jane McEneny Journal: J Reprod Med Date: 2013 Mar-Apr Impact factor: 0.142
Authors: Marcio S Medeiros; Arthur Schumacher-Schuh; Andreia Machado Cardoso; Guilherme Vargas Bochi; Jucimara Baldissarelli; Aline Kegler; Daniel Santana; Carolina Maria Martins Behle Soares Chaves; Maria Rosa Chitolina Schetinger; Rafael Noal Moresco; Carlos R M Rieder; Michele Rechia Fighera Journal: PLoS One Date: 2016-01-11 Impact factor: 3.240