Literature DB >> 2157633

Increase in free radical generation and lipid peroxidation following chemotherapy in patients with cancer.

P Sangeetha1, U N Das, R Koratkar, P Suryaprabha.   

Abstract

Several anti-cancer drugs are known to bring about their tumoricidal actions by a free radical dependent mechanism. Majority of the studies reported that adriamycin, mitomycin C, bleomycin, etc., augment free radical generation and lipid peroxidation process in vitro. Our results reported here suggest that following chemotherapy both stimulated and unstimulated human polymorphonuclear leukocytes generate increased amounts of superoxide anion and hydrogen peroxide. This was accompanied by increased formation of lipid peroxidation products as measured by thiobarbituric acid assay. These results confirm that many anti-cancer drugs augment free radical generation and lipid peroxidation even in an vivo situation.

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Year:  1990        PMID： 2157633     DOI： 10.1016/0891-5849(90)90139-a

Source DB:  PubMed          Journal:  Free Radic Biol Med        ISSN： 0891-5849            Impact factor:   7.376


  39 in total

1.  Serum antioxidant capacity, biochemical profile and body composition of breast cancer survivors in a randomized Mediterranean dietary intervention study.

Authors:  Maria Skouroliakou; D Grosomanidis; P Massara; C Kostara; P Papandreou; D Ntountaniotis; G Xepapadakis
Journal:  Eur J Nutr       Date:  2017-06-20       Impact factor: 5.614

2.  Increased rate of drying reduces metabolic inequity and critical water content in radicles of Cicer arietinum L.

Authors:  Jipsi Chandra; Mona Tandon; S Keshavkant
Journal:  Physiol Mol Biol Plants       Date:  2015-04-08

Review 3.  The Role of Biomarkers of Oxidative Stress in Breast Cancer Risk and Prognosis: A Systematic Review of the Epidemiologic Literature.

Authors:  Jasmine D Lee; Qiuyin Cai; Xiao Ou Shu; Sarah J Nechuta
Journal:  J Womens Health (Larchmt)       Date:  2017-02-02       Impact factor: 2.681

4.  Protective effect of Phyllanthus fraternus against mitochondrial dysfunction induced by co-administration of cisplatin and cyclophosphamide.

Authors:  Kavita K Kumari; O H Setty
Journal:  J Bioenerg Biomembr       Date:  2012-02-24       Impact factor: 2.945

5.  Nitro aspirin (NCX4040) induces apoptosis in PC3 metastatic prostate cancer cells via hydrogen peroxide (H2O2)-mediated oxidative stress.

Authors:  Somaiah Chinnapaka; Guoxing Zheng; Aoshuang Chen; Gnanasekar Munirathinam
Journal:  Free Radic Biol Med       Date:  2019-08-22       Impact factor: 7.376

6.  Antioxidant supplementation has a positive effect on oxidative stress and hematological toxicity during oncology treatment in cervical cancer patients.

Authors:  Vanessa Fuchs-Tarlovsky; María Amanda Casillas Rivera; Karolina Alvarez Altamirano; Juan Carlos Lopez-Alvarenga; Guillermo Manuel Ceballos-Reyes
Journal:  Support Care Cancer       Date:  2012-12-14       Impact factor: 3.603

7.  Effect on Antioxidant Levels in Patients of Breast Carcinoma during Neoadjuvant Chemotherapy and Mastectomy.

Authors:  Gurpreet Singh; Sk Maulik; Amardeep Jaiswal; Pratik Kumar; Rajinder Parshad
Journal:  Malays J Med Sci       Date:  2010-04

8.  Desiccation-induced ROS accumulation and lipid catabolism in recalcitrant Madhuca latifolia seeds.

Authors:  Jipsi Chandra; S Keshavkant
Journal:  Physiol Mol Biol Plants       Date:  2017-12-18

9.  Evaluation of protein oxidation and its association with lipid peroxidation and thyrotropin levels in overt and subclinical hypothyroidism.

Authors:  A Haribabu; V Seshadri Reddy; Ch Pallavi; Aparna R Bitla; Alok Sachan; P Pullaiah; V Suresh; P V L N Srinivasa Rao; M M Suchitra
Journal:  Endocrine       Date:  2012-12-08       Impact factor: 3.633

10.  Oxidative stress in non-obese women with polycystic ovarian syndrome.

Authors:  Varalakshmi Desai; Namburi Rajendra Prasad; Suchitra Musturu Manohar; Alok Sachan; Srinivasa Rao Pemmaraju Venkata Lakshmi Narasimha; Aparna Rajeshwar Rao Bitla
Journal:  J Clin Diagn Res       Date:  2014-07-20
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