| Literature DB >> 25176646 |
Xiaodong Fang1, Inge Seim2, Zhiyong Huang3, Maxim V Gerashchenko4, Zhiqiang Xiong3, Anton A Turanov4, Yabing Zhu3, Alexei V Lobanov4, Dingding Fan3, Sun Hee Yim4, Xiaoming Yao3, Siming Ma4, Lan Yang3, Sang-Goo Lee2, Eun Bae Kim5, Roderick T Bronson6, Radim Šumbera7, Rochelle Buffenstein8, Xin Zhou3, Anders Krogh9, Thomas J Park10, Guojie Zhang1, Jun Wang11, Vadim N Gladyshev12.
Abstract
Subterranean mammals spend their lives in dark, unventilated environments that are rich in carbon dioxide and ammonia and low in oxygen. Many of these animals are also long-lived and exhibit reduced aging-associated diseases, such as neurodegenerative disorders and cancer. We sequenced the genome of the Damaraland mole rat (DMR, Fukomys damarensis) and improved the genome assembly of the naked mole rat (NMR, Heterocephalus glaber). Comparative genome analyses, along with the transcriptomes of related subterranean rodents, revealed candidate molecular adaptations for subterranean life and longevity, including a divergent insulin peptide, expression of oxygen-carrying globins in the brain, prevention of high CO2-induced pain perception, and enhanced ammonia detoxification. Juxtaposition of the genomes of DMR and other more conventional animals with the genome of NMR revealed several truly exceptional NMR features: unusual thermogenesis, an aberrant melatonin system, pain insensitivity, and unique processing of 28S rRNA. Together, these genomes and transcriptomes extend our understanding of subterranean adaptations, stress resistance, and longevity.Entities:
Mesh：
Substances：
Year: 2014 PMID： 25176646 PMCID： PMC4350764 DOI： 10.1016/j.celrep.2014.07.030
Source DB: PubMed Journal: Cell Rep Impact factor: 9.423