Briseis Aschebrook-Kilfoy1, Pierluigi Cocco1, Carlo La Vecchia1, Ellen T Chang1, Claire M Vajdic1, Marshall E Kadin1, John J Spinelli1, Lindsay M Morton1, Eleanor V Kane1, Joshua N Sampson1, Carol Kasten1, Andrew L Feldman1, Sophia S Wang1, Yawei Zhang2. 1. Department of Health Studies, University of Chicago, Chicago, IL (BA-K); Department of Public Health, Clinical and Molecular Medicine, Occupational Health Section, University of Cagliari, Cagliari, Italy (PC); Dipartimento di Epidimologia, IRCCS- Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, Community Health, University of Milan, Milan, Italy (CLV); Health Sciences Practice, Exponent, Inc., Menlo Park, CA, Department of Health Research and Policy, Stanford University, Stanford, CA (ETC); Prince of Wales Clinical School, University of New South Wales, Sydney, Australia (CMV); Department of Dermatology, Boston University, Boston, MA, Roger Williams Medical Center, Providence, RI (MEK); Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada (JJS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health Bethesda, MD (LMM, JNS); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK (EVK); Biostatistics Center, Massachusetts General Hospital, Boston, MA (CK); Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, MN (ALF); Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA (SSW); Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT (YZ). 2. Department of Health Studies, University of Chicago, Chicago, IL (BA-K); Department of Public Health, Clinical and Molecular Medicine, Occupational Health Section, University of Cagliari, Cagliari, Italy (PC); Dipartimento di Epidimologia, IRCCS- Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, Community Health, University of Milan, Milan, Italy (CLV); Health Sciences Practice, Exponent, Inc., Menlo Park, CA, Department of Health Research and Policy, Stanford University, Stanford, CA (ETC); Prince of Wales Clinical School, University of New South Wales, Sydney, Australia (CMV); Department of Dermatology, Boston University, Boston, MA, Roger Williams Medical Center, Providence, RI (MEK); Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada (JJS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health Bethesda, MD (LMM, JNS); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK (EVK); Biostatistics Center, Massachusetts General Hospital, Boston, MA (CK); Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, MN (ALF); Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA (SSW); Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT (YZ). yawei.zhang@yale.edu.
Abstract
BACKGROUND: Mycosis fungoides and Sézary syndrome (MF/SS) are rare cutaneous T-cell lymphomas. Their etiology is poorly understood. METHODS: A pooled analysis of 324 MF/SS cases and 17217 controls from 14 case-control studies from Europe, North America, and Australia, as part of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma (NHL) Subtypes Project, was carried out to investigate associations with lifestyle, medical history, family history, and occupational risk factors. Multivariate logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: We found an increased risk of MF/SS associated with body mass index equal to or larger than 30 kg/m(2) (OR = 1.57, 95% CI = 1.03 to 2.40), cigarette smoking for 40 years or more (OR = 1.55, 95% CI = 1.04 to 2.31), eczema (OR = 2.38, 95% CI = 1.73 to 3.29), family history of multiple myeloma (OR = 8.49, 95% CI = 3.31 to 21.80), and occupation as crop and vegetable farmers (OR = 2.37, 95% CI = 1.14 to 4.92), painters (OR = 3.71, 95% CI = 1.94 to 7.07), woodworkers (OR = 2.20, 95% CI = 1.18 to 4.08), and general carpenters (OR = 4.07, 95% CI = 1.54 to 10.75). We also found a reduced risk of MF/SS associated with moderate leisure time physical activity (OR = 0.46, 95% CI = 0.22 to 0.97). CONCLUSIONS: Our study provided the first detailed analysis of risk factors for MF/SS and further investigation is needed to confirm these findings in prospective data and in other populations. Published by Oxford University Press 2014.
BACKGROUND:Mycosis fungoides and Sézary syndrome (MF/SS) are rare cutaneous T-cell lymphomas. Their etiology is poorly understood. METHODS: A pooled analysis of 324 MF/SS cases and 17217 controls from 14 case-control studies from Europe, North America, and Australia, as part of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma (NHL) Subtypes Project, was carried out to investigate associations with lifestyle, medical history, family history, and occupational risk factors. Multivariate logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: We found an increased risk of MF/SS associated with body mass index equal to or larger than 30 kg/m(2) (OR = 1.57, 95% CI = 1.03 to 2.40), cigarette smoking for 40 years or more (OR = 1.55, 95% CI = 1.04 to 2.31), eczema (OR = 2.38, 95% CI = 1.73 to 3.29), family history of multiple myeloma (OR = 8.49, 95% CI = 3.31 to 21.80), and occupation as crop and vegetable farmers (OR = 2.37, 95% CI = 1.14 to 4.92), painters (OR = 3.71, 95% CI = 1.94 to 7.07), woodworkers (OR = 2.20, 95% CI = 1.18 to 4.08), and general carpenters (OR = 4.07, 95% CI = 1.54 to 10.75). We also found a reduced risk of MF/SS associated with moderate leisure time physical activity (OR = 0.46, 95% CI = 0.22 to 0.97). CONCLUSIONS: Our study provided the first detailed analysis of risk factors for MF/SS and further investigation is needed to confirm these findings in prospective data and in other populations. Published by Oxford University Press 2014.
Authors: M S Linet; J K McLaughlin; J F Fraumeni; H S Malker; J A Weiner; J L Ericsson Journal: J Natl Cancer Inst Date: 1989-12-06 Impact factor: 13.506
Authors: M M Morales Suárez-Varela; J Olsen; L Kaerlev; P Guénel; P Arveux; G Wingren; L Hardell; W Ahrens; A Stang; A Llopis-Gonzalez; F Merletti; F Guillén-Grima; P Johansen Journal: Eur J Cancer Date: 2001-02 Impact factor: 9.162
Authors: Claire M Vajdic; Michael O Falster; Silvia de Sanjose; Otoniel Martínez-Maza; Nikolaus Becker; Paige M Bracci; Mads Melbye; Karin Ekström Smedby; Eric A Engels; Jennifer Turner; Paolo Vineis; Adele Seniori Costantini; Elizabeth A Holly; Eleanor Kane; John J Spinelli; Carlo La Vecchia; Tongzhang Zheng; Brian C-H Chiu; Luigino Dal Maso; Pierluigi Cocco; Marc Maynadié; Lenka Foretova; Anthony Staines; Paul Brennan; Scott Davis; Richard Severson; James R Cerhan; Elizabeth C Breen; Brenda Birmann; Wendy Cozen; Andrew E Grulich Journal: Cancer Res Date: 2009-08-04 Impact factor: 12.701
Authors: A S Whittemore; E A Holly; I M Lee; E A Abel; R M Adams; B J Nickoloff; L Bley; J M Peters; C Gibney Journal: J Natl Cancer Inst Date: 1989-10-18 Impact factor: 13.506
Authors: Jean L Koff; Dai Chihara; Anh Phan; Loretta J Nastoupil; Jessica N Williams; Christopher R Flowers Journal: Curr Hematol Malig Rep Date: 2015-09 Impact factor: 3.952
Authors: Dai Chihara; Loretta J Nastoupil; Jessica N Williams; Paul Lee; Jean L Koff; Christopher R Flowers Journal: Expert Rev Anticancer Ther Date: 2015-04-11 Impact factor: 4.512
Authors: Morgan Nguyen; Tessa LeWitt; Yanzhen Pang; Katherine Bagnowski; Maria L Espinosa; Jaehyuk Choi; Joan Guitart; Walter Liszewski; Xiaolong Alan Zhou Journal: Arch Dermatol Res Date: 2022-06-06 Impact factor: 3.017
Authors: Eric A Engels; Ruth Parsons; Caroline Besson; Lindsay M Morton; Lindsey Enewold; Winnie Ricker; Elizabeth L Yanik; Hannah Arem; April A Austin; Ruth M Pfeiffer Journal: Cancer Epidemiol Biomarkers Prev Date: 2016-04-26 Impact factor: 4.254
Authors: Andreas Willerslev-Olsen; Thorbjørn Krejsgaard; Lise M Lindahl; Ivan V Litvinov; Simon Fredholm; David L Petersen; Claudia Nastasi; Robert Gniadecki; Nigel P Mongan; Denis Sasseville; Mariusz A Wasik; Charlotte M Bonefeld; Carsten Geisler; Anders Woetmann; Lars Iversen; Mogens Kilian; Sergei B Koralov; Niels Odum Journal: Blood Date: 2016-01-05 Impact factor: 22.113
Authors: Lindsay M Morton; Joshua N Sampson; James R Cerhan; Jennifer J Turner; Claire M Vajdic; Sophia S Wang; Karin E Smedby; Silvia de Sanjosé; Alain Monnereau; Yolanda Benavente; Paige M Bracci; Brian C H Chiu; Christine F Skibola; Yawei Zhang; Sam M Mbulaiteye; Michael Spriggs; Dennis Robinson; Aaron D Norman; Eleanor V Kane; John J Spinelli; Jennifer L Kelly; Carlo La Vecchia; Luigino Dal Maso; Marc Maynadié; Marshall E Kadin; Pierluigi Cocco; Adele Seniori Costantini; Christina A Clarke; Eve Roman; Lucia Miligi; Joanne S Colt; Sonja I Berndt; Andrea Mannetje; Anneclaire J de Roos; Anne Kricker; Alexandra Nieters; Silvia Franceschi; Mads Melbye; Paolo Boffetta; Jacqueline Clavel; Martha S Linet; Dennis D Weisenburger; Susan L Slager Journal: J Natl Cancer Inst Monogr Date: 2014-08
Authors: Lindsay M Morton; Susan L Slager; James R Cerhan; Sophia S Wang; Claire M Vajdic; Christine F Skibola; Paige M Bracci; Silvia de Sanjosé; Karin E Smedby; Brian C H Chiu; Yawei Zhang; Sam M Mbulaiteye; Alain Monnereau; Jennifer J Turner; Jacqueline Clavel; Hans-Olov Adami; Ellen T Chang; Bengt Glimelius; Henrik Hjalgrim; Mads Melbye; Paolo Crosignani; Simonetta di Lollo; Lucia Miligi; Oriana Nanni; Valerio Ramazzotti; Stefania Rodella; Adele Seniori Costantini; Emanuele Stagnaro; Rosario Tumino; Carla Vindigni; Paolo Vineis; Nikolaus Becker; Yolanda Benavente; Paolo Boffetta; Paul Brennan; Pierluigi Cocco; Lenka Foretova; Marc Maynadié; Alexandra Nieters; Anthony Staines; Joanne S Colt; Wendy Cozen; Scott Davis; Anneclaire J de Roos; Patricia Hartge; Nathaniel Rothman; Richard K Severson; Elizabeth A Holly; Timothy G Call; Andrew L Feldman; Thomas M Habermann; Mark Liebow; Aaron Blair; Kenneth P Cantor; Eleanor V Kane; Tracy Lightfoot; Eve Roman; Alex Smith; Angela Brooks-Wilson; Joseph M Connors; Randy D Gascoyne; John J Spinelli; Bruce K Armstrong; Anne Kricker; Theodore R Holford; Qing Lan; Tongzhang Zheng; Laurent Orsi; Luigino Dal Maso; Silvia Franceschi; Carlo La Vecchia; Eva Negri; Diego Serraino; Leslie Bernstein; Alexandra Levine; Jonathan W Friedberg; Jennifer L Kelly; Sonja I Berndt; Brenda M Birmann; Christina A Clarke; Christopher R Flowers; James M Foran; Marshall E Kadin; Ora Paltiel; Dennis D Weisenburger; Martha S Linet; Joshua N Sampson Journal: J Natl Cancer Inst Monogr Date: 2014-08