Literature DB >> 27704468

Sézary Syndrome: Clinical and Biological Aspects.

Rebecca Kohnken1, Stephanie Fabbro2, Justin Hastings2, Pierluigi Porcu3,4, Anjali Mishra5,6.   

Abstract

Sézary syndrome (SS) is a rare and aggressive type of cutaneous T cell lymphoma (CTCL) characterized by an intensely pruritic, exfoliative rash, known as erythroderma, with cutaneous and systemic dissemination of clonal CD4+ T cells into the blood and lymph nodes. This review aims to present recent advancements in the biological and clinical aspects of SS. We begin by providing an overview of the diagnostic criteria for SS and reviewing some of its epidemiological and clinical aspects. We then discuss updates in the etiology of this elusive disease and the genetic and molecular landscapes that define it. Finally, we provide a short overview of the current therapeutic strategies for SS as well as recent advances in the prognosis of this disease. A brief set of recommendations is provided regarding future directions in research and therapy.

Entities:  

Keywords:  Cutaneous T cell lymphoma; Lymphoproliferative malignancies; Sézary syndrome

Mesh：

Substances：

Year:  2016        PMID： 27704468     DOI： 10.1007/s11899-016-0351-0

Source DB:  PubMed          Journal:  Curr Hematol Malig Rep        ISSN： 1558-8211            Impact factor:   3.952


  105 in total

1.  Skin homing of Sézary cells involves SDF-1-CXCR4 signaling and down-regulation of CD26/dipeptidylpeptidase IV.

Authors:  Maria Grazia Narducci; Enrico Scala; Antonella Bresin; Elisabetta Caprini; Maria Cristina Picchio; Daniele Remotti; Gianluca Ragone; Francesca Nasorri; Marina Frontani; Diego Arcelli; Stefano Volinia; Giuseppe Alfonso Lombardo; Giannandrea Baliva; Monica Napolitano; Giandomenico Russo
Journal:  Blood       Date:  2005-10-04       Impact factor: 22.113

2.  Constitutive and interleukin-7/interleukin-15 stimulated DNA binding of Myc, Jun, and novel Myc-like proteins in cutaneous T-cell lymphoma cells.

Authors:  J Z Qin; R Dummer; G Burg; U Döbbeling
Journal:  Blood       Date:  1999-01-01       Impact factor: 22.113

3.  Characterization of the DNA copy-number genome in the blood of cutaneous T-cell lymphoma patients.

Authors:  William M Lin; Julia M Lewis; Renata B Filler; Badri G Modi; Kacie R Carlson; Swapna Reddy; Adam Thornberg; Gordon Saksena; Sheila Umlauf; Patrick A Oberholzer; Maria Karpova; Gad Getz; Shrikant Mane; Levi A Garraway; Reinhard Dummer; Carole L Berger; Richard L Edelson; Michael Girardi
Journal:  J Invest Dermatol       Date:  2011-09-01       Impact factor: 8.551

4.  Changing incidence trends of cutaneous T-cell lymphoma.

Authors:  Kaveri Korgavkar; Michael Xiong; Martin Weinstock
Journal:  JAMA Dermatol       Date:  2013-11       Impact factor: 10.282

5.  Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma.

Authors:  Elise A Olsen; Youn H Kim; Timothy M Kuzel; Theresa R Pacheco; Francine M Foss; Sareeta Parker; Stanley R Frankel; Cong Chen; Justin L Ricker; Jean Marie Arduino; Madeleine Duvic
Journal:  J Clin Oncol       Date:  2007-06-18       Impact factor: 44.544

6.  Malignant Tregs express low molecular splice forms of FOXP3 in Sézary syndrome.

Authors:  T Krejsgaard; L M Gjerdrum; E Ralfkiaer; B Lauenborg; K W Eriksen; A-M Mathiesen; L F Bovin; R Gniadecki; C Geisler; L P Ryder; Q Zhang; M A Wasik; N Odum; A Woetmann
Journal:  Leukemia       Date:  2008-09-04       Impact factor: 11.528

7.  A cutaneous lymphoma international prognostic index (CLIPi) for mycosis fungoides and Sezary syndrome.

Authors:  E C Benton; S Crichton; R Talpur; N S Agar; P A Fields; E Wedgeworth; T J Mitchell; M Cox; S Ferreira; P Liu; A Robson; E Calonje; C M Stefanato; B Wilkins; J Scarisbrick; E M Wain; F Child; S Morris; M Duvic; S J Whittaker
Journal:  Eur J Cancer       Date:  2013-06-01       Impact factor: 9.162

8.  Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma.

Authors:  Anjali Mishra; Krista La Perle; Sonya Kwiatkowski; Laura A Sullivan; Gregory H Sams; Jessica Johns; Douglas P Curphey; Jing Wen; Kathleen McConnell; Jun Qi; Henry Wong; Giandomenico Russo; Jianying Zhang; Guido Marcucci; James E Bradner; Pierluigi Porcu; Michael A Caligiuri
Journal:  Cancer Discov       Date:  2016-07-15       Impact factor: 39.397

9.  Incidence of cutaneous T-cell lymphoma in the United States, 1973-2002.

Authors:  Vincent D Criscione; Martin A Weinstock
Journal:  Arch Dermatol       Date:  2007-07

10.  Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes.

Authors:  Linghua Wang; Xiao Ni; Kyle R Covington; Betty Y Yang; Jessica Shiu; Xiang Zhang; Liu Xi; Qingchang Meng; Timothy Langridge; Jennifer Drummond; Lawrence A Donehower; Harshavardhan Doddapaneni; Donna M Muzny; Richard A Gibbs; David A Wheeler; Madeleine Duvic
Journal:  Nat Genet       Date:  2015-11-09       Impact factor: 38.330
View more
  4 in total

1.  Diminished microRNA-29b level is associated with BRD4-mediated activation of oncogenes in cutaneous T-cell lymphoma.

Authors:  Rebecca Kohnken; Jing Wen; Bethany Mundy-Bosse; Kathleen McConnell; Ashleigh Keiter; Leah Grinshpun; Alex Hartlage; Max Yano; Betina McNeil; Nitin Chakravarti; Basem William; James E Bradner; Michael A Caligiuri; Pierluigi Porcu; Anjali Mishra
Journal:  Blood       Date:  2017-11-27       Impact factor: 22.113

2.  Highly cytotoxic natural killer cells are associated with poor prognosis in patients with cutaneous T-cell lymphoma.

Authors:  Bethany Mundy-Bosse; Nathan Denlinger; Eric McLaughlin; Nitin Chakravarti; Susan Hwang; Li Chen; Hsiaoyin Charlene Mao; David Kline; Youssef Youssef; Rebecca Kohnken; Dean Anthony Lee; Gerard Lozanski; Aharon G Freud; Pierluigi Porcu; Basem William; Michael A Caligiuri; Anjali Mishra
Journal:  Blood Adv       Date:  2018-08-14

Review 3.  Multidisciplinary Management of Mycosis Fungoides/Sézary Syndrome.

Authors:  Sara Berg; Jennifer Villasenor-Park; Paul Haun; Ellen J Kim
Journal:  Curr Hematol Malig Rep       Date:  2017-06       Impact factor: 3.952

Review 4.  The Role of Tumor Microenvironment in the Pathogenesis of Sézary Syndrome.

Authors:  Denis Miyashiro; Bruno de Castro E Souza; Marina Passos Torrealba; Kelly Cristina Gomes Manfrere; Maria Notomi Sato; José Antonio Sanches
Journal:  Int J Mol Sci       Date:  2022-01-15       Impact factor: 5.923
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.