Literature DB >> 27197296

Comprehensive Evaluation of Medical Conditions Associated with Risk of Non-Hodgkin Lymphoma using Medicare Claims ("MedWAS").

Eric A Engels1, Ruth Parsons2, Caroline Besson3, Lindsay M Morton4, Lindsey Enewold5, Winnie Ricker2, Elizabeth L Yanik4, Hannah Arem4, April A Austin6, Ruth M Pfeiffer4.   

Abstract

BACKGROUND: Certain medical conditions affect risk of non-Hodgkin lymphoma (NHL), but the full range of associations is unknown. We implemented a novel method ("medical condition-wide association study," MedWAS) to comprehensively evaluate medical risk factors for NHL documented in administrative health claims.
METHODS: Using Surveillance, Epidemiology, and End Results (SEER)-Medicare data, we conducted a case-control study comparing NHL cases [N = 52,691, age 66+ years, with five subtypes: chronic lymphocytic leukemia/small lymphocytic lymphoma, diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, marginal zone lymphoma (MZL), T-cell lymphoma (TCL)] to controls (N = 200,000). We systematically screened for associations with 5,926 medical conditions documented in Medicare claims more than 1 year before selection.
RESULTS: Fifty-five conditions were variously associated with NHL. Examples include well-established associations of human immunodeficiency virus, solid organ transplantation, and hepatitis C virus with increased DLBCL risk (ORs 3.83, 4.27, and 1.74, respectively), and autoimmune conditions with DLBCL and MZL (e.g., ORs of 2.10 and 4.74, respectively, for Sjögren syndrome). Risks for all NHL subtypes were increased after diagnoses of nonmelanoma skin cancer (ORs 1.19-1.55), actinic keratosis (1.12-1.25), or hemolytic anemia (1.64-4.07). Nine additional skin conditions increased only TCL risk (ORs 2.20-4.12). Diabetes mellitus was associated with increased DLBCL risk (OR 1.09). Associations varied significantly across NHL subtypes for 49 conditions (89%).
CONCLUSION: Using an exploratory method, we found numerous medical conditions associated with NHL risk, and many associations varied across NHL subtypes. IMPACT: These results point to etiologic heterogeneity among NHL subtypes. MedWAS is a new method for assessing the etiology of cancer and other diseases. Cancer Epidemiol Biomarkers Prev; 25(7); 1105-13. ©2016 AACR. ©2016 American Association for Cancer Research.

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Year:  2016        PMID: 27197296      PMCID: PMC4930732          DOI: 10.1158/1055-9965.EPI-16-0212

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN: 1055-9965            Impact factor:   4.254


  45 in total

1.  HIV infection status, immunodeficiency, and the incidence of non-melanoma skin cancer.

Authors:  Michael J Silverberg; Wendy Leyden; E Margaret Warton; Charles P Quesenberry; Eric A Engels; Maryam M Asgari
Journal:  J Natl Cancer Inst       Date:  2013-01-04       Impact factor: 13.506

2.  Use of surveillance, epidemiology, and end results-medicare data to conduct case-control studies of cancer among the US elderly.

Authors:  Eric A Engels; Ruth M Pfeiffer; Winnie Ricker; William Wheeler; Ruth Parsons; Joan L Warren
Journal:  Am J Epidemiol       Date:  2011-08-04       Impact factor: 4.897

3.  Metabolic syndrome increases the risk of primary liver cancer in the United States: a study in the SEER-Medicare database.

Authors:  Tania M Welzel; Barry I Graubard; Stefan Zeuzem; Hashem B El-Serag; Jessica A Davila; Katherine A McGlynn
Journal:  Hepatology       Date:  2011-06-30       Impact factor: 17.425

4.  Hepatitis C and non-Hodgkin lymphoma among 4784 cases and 6269 controls from the International Lymphoma Epidemiology Consortium.

Authors:  Silvia de Sanjose; Yolanda Benavente; Claire M Vajdic; Eric A Engels; Lindsay M Morton; Paige M Bracci; John J Spinelli; Tongzhang Zheng; Yawei Zhang; Silvia Franceschi; Renato Talamini; Elizabeth A Holly; Andrew E Grulich; James R Cerhan; Patricia Hartge; Wendy Cozen; Paolo Boffetta; Paul Brennan; Marc Maynadié; Pierluigi Cocco; Ramon Bosch; Lenka Foretova; Anthony Staines; Nikolaus Becker; Alexandra Nieters
Journal:  Clin Gastroenterol Hepatol       Date:  2008-04       Impact factor: 11.382

Review 5.  A revision on cryoglobulinaemia associated to neoplastic diseases.

Authors:  M J Molina-Garrido; C Guillén-Ponce
Journal:  Clin Transl Oncol       Date:  2007-04       Impact factor: 3.405

6.  Gallstones, cholecystectomy, and risk of digestive system cancers.

Authors:  Leticia Nogueira; Neal D Freedman; Eric A Engels; Joan L Warren; Felipe Castro; Jill Koshiol
Journal:  Am J Epidemiol       Date:  2014-01-26       Impact factor: 4.897

7.  Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based case-control study.

Authors:  Tania M Welzel; Barry I Graubard; Hashem B El-Serag; Yasser H Shaib; Ann W Hsing; Jessica A Davila; Katherine A McGlynn
Journal:  Clin Gastroenterol Hepatol       Date:  2007-08-06       Impact factor: 11.382

Review 8.  Diagnosis and management of autoimmune complications of chronic lymphocytic leukemia/ small lymphocytic lymphoma.

Authors:  Wei Ding; Clive S Zent
Journal:  Clin Adv Hematol Oncol       Date:  2007-04

9.  Etiologic heterogeneity among non-Hodgkin lymphoma subtypes: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.

Authors:  Lindsay M Morton; Susan L Slager; James R Cerhan; Sophia S Wang; Claire M Vajdic; Christine F Skibola; Paige M Bracci; Silvia de Sanjosé; Karin E Smedby; Brian C H Chiu; Yawei Zhang; Sam M Mbulaiteye; Alain Monnereau; Jennifer J Turner; Jacqueline Clavel; Hans-Olov Adami; Ellen T Chang; Bengt Glimelius; Henrik Hjalgrim; Mads Melbye; Paolo Crosignani; Simonetta di Lollo; Lucia Miligi; Oriana Nanni; Valerio Ramazzotti; Stefania Rodella; Adele Seniori Costantini; Emanuele Stagnaro; Rosario Tumino; Carla Vindigni; Paolo Vineis; Nikolaus Becker; Yolanda Benavente; Paolo Boffetta; Paul Brennan; Pierluigi Cocco; Lenka Foretova; Marc Maynadié; Alexandra Nieters; Anthony Staines; Joanne S Colt; Wendy Cozen; Scott Davis; Anneclaire J de Roos; Patricia Hartge; Nathaniel Rothman; Richard K Severson; Elizabeth A Holly; Timothy G Call; Andrew L Feldman; Thomas M Habermann; Mark Liebow; Aaron Blair; Kenneth P Cantor; Eleanor V Kane; Tracy Lightfoot; Eve Roman; Alex Smith; Angela Brooks-Wilson; Joseph M Connors; Randy D Gascoyne; John J Spinelli; Bruce K Armstrong; Anne Kricker; Theodore R Holford; Qing Lan; Tongzhang Zheng; Laurent Orsi; Luigino Dal Maso; Silvia Franceschi; Carlo La Vecchia; Eva Negri; Diego Serraino; Leslie Bernstein; Alexandra Levine; Jonathan W Friedberg; Jennifer L Kelly; Sonja I Berndt; Brenda M Birmann; Christina A Clarke; Christopher R Flowers; James M Foran; Marshall E Kadin; Ora Paltiel; Dennis D Weisenburger; Martha S Linet; Joshua N Sampson
Journal:  J Natl Cancer Inst Monogr       Date:  2014-08

10.  Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.

Authors:  Sonja I Berndt; Christine F Skibola; Vijai Joseph; Nicola J Camp; Alexandra Nieters; Zhaoming Wang; Wendy Cozen; Alain Monnereau; Sophia S Wang; Rachel S Kelly; Qing Lan; Lauren R Teras; Nilanjan Chatterjee; Charles C Chung; Meredith Yeager; Angela R Brooks-Wilson; Patricia Hartge; Mark P Purdue; Brenda M Birmann; Bruce K Armstrong; Pierluigi Cocco; Yawei Zhang; Gianluca Severi; Anne Zeleniuch-Jacquotte; Charles Lawrence; Laurie Burdette; Jeffrey Yuenger; Amy Hutchinson; Kevin B Jacobs; Timothy G Call; Tait D Shanafelt; Anne J Novak; Neil E Kay; Mark Liebow; Alice H Wang; Karin E Smedby; Hans-Olov Adami; Mads Melbye; Bengt Glimelius; Ellen T Chang; Martha Glenn; Karen Curtin; Lisa A Cannon-Albright; Brandt Jones; W Ryan Diver; Brian K Link; George J Weiner; Lucia Conde; Paige M Bracci; Jacques Riby; Elizabeth A Holly; Martyn T Smith; Rebecca D Jackson; Lesley F Tinker; Yolanda Benavente; Nikolaus Becker; Paolo Boffetta; Paul Brennan; Lenka Foretova; Marc Maynadie; James McKay; Anthony Staines; Kari G Rabe; Sara J Achenbach; Celine M Vachon; Lynn R Goldin; Sara S Strom; Mark C Lanasa; Logan G Spector; Jose F Leis; Julie M Cunningham; J Brice Weinberg; Vicki A Morrison; Neil E Caporaso; Aaron D Norman; Martha S Linet; Anneclaire J De Roos; Lindsay M Morton; Richard K Severson; Elio Riboli; Paolo Vineis; Rudolph Kaaks; Dimitrios Trichopoulos; Giovanna Masala; Elisabete Weiderpass; María-Dolores Chirlaque; Roel C H Vermeulen; Ruth C Travis; Graham G Giles; Demetrius Albanes; Jarmo Virtamo; Stephanie Weinstein; Jacqueline Clavel; Tongzhang Zheng; Theodore R Holford; Kenneth Offit; Andrew Zelenetz; Robert J Klein; John J Spinelli; Kimberly A Bertrand; Francine Laden; Edward Giovannucci; Peter Kraft; Anne Kricker; Jenny Turner; Claire M Vajdic; Maria Grazia Ennas; Giovanni M Ferri; Lucia Miligi; Liming Liang; Joshua Sampson; Simon Crouch; Ju-Hyun Park; Kari E North; Angela Cox; John A Snowden; Josh Wright; Angel Carracedo; Carlos Lopez-Otin; Silvia Bea; Itziar Salaverria; David Martin-Garcia; Elias Campo; Joseph F Fraumeni; Silvia de Sanjose; Henrik Hjalgrim; James R Cerhan; Stephen J Chanock; Nathaniel Rothman; Susan L Slager
Journal:  Nat Genet       Date:  2013-06-16       Impact factor: 41.307

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  10 in total

1.  RE: The Association of Dyslipidemia With Chronic Lymphocytic Leukemia: A Population-Based Study.

Authors:  Eric A Engels; Ruth Parsons; Caroline Besson; Lindsay M Morton; Elizabeth L Yanik; Hannah Arem; Ruth M Pfeiffer
Journal:  J Natl Cancer Inst       Date:  2017-04-01       Impact factor: 13.506

2.  Sex differential association of dermatomyositis with Sjögren syndrome.

Authors:  Chia-Chun Tseng; Shun-Jen Chang; Wen-Chan Tsai; Tsan-Teng Ou; Cheng-Chin Wu; Wan-Yu Sung; Ming-Chia Hsieh; Jeng-Hsien Yen
Journal:  CMAJ       Date:  2017-02-06       Impact factor: 8.262

3.  Gender-sensitive word embeddings for healthcare.

Authors:  Shunit Agmon; Plia Gillis; Eric Horvitz; Kira Radinsky
Journal:  J Am Med Inform Assoc       Date:  2022-01-29       Impact factor: 4.497

4.  pyPheWAS: A Phenome-Disease Association Tool for Electronic Medical Record Analysis.

Authors:  Cailey I Kerley; Shikha Chaganti; Tin Q Nguyen; Camilo Bermudez; Laurie E Cutting; Lori L Beason-Held; Thomas Lasko; Bennett A Landman
Journal:  Neuroinformatics       Date:  2022-01-03

5.  Epidemiology of Marginal Zone Lymphoma.

Authors:  James R Cerhan; Thomas M Habermann
Journal:  Ann Lymphoma       Date:  2021-03-30

6.  HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes.

Authors:  Sophia S Wang; Mary Carrington; Sonja I Berndt; Susan L Slager; Paige M Bracci; Jenna Voutsinas; James R Cerhan; Karin E Smedby; Henrik Hjalgrim; Joseph Vijai; Lindsay M Morton; Roel Vermeulen; Ora Paltiel; Claire M Vajdic; Martha S Linet; Alexandra Nieters; Silvia de Sanjose; Wendy Cozen; Elizabeth E Brown; Jennifer Turner; John J Spinelli; Tongzhang Zheng; Brenda M Birmann; Christopher R Flowers; Nikolaus Becker; Elizabeth A Holly; Eleanor Kane; Dennis Weisenburger; Marc Maynadie; Pierluigi Cocco; Demetrius Albanes; Stephanie J Weinstein; Lauren R Teras; W Ryan Diver; Stephanie J Lax; Ruth C Travis; Rudolph Kaaks; Elio Riboli; Yolanda Benavente; Paul Brennan; James McKay; Marie-Hélène Delfau-Larue; Brian K Link; Corrado Magnani; Maria Grazia Ennas; Giancarlo Latte; Andrew L Feldman; Nicole Wong Doo; Graham G Giles; Melissa C Southey; Roger L Milne; Kenneth Offit; Jacob Musinsky; Alan A Arslan; Mark P Purdue; Hans-Olov Adami; Mads Melbye; Bengt Glimelius; Lucia Conde; Nicola J Camp; Martha Glenn; Karen Curtin; Jacqueline Clavel; Alain Monnereau; David G Cox; Hervé Ghesquières; Gilles Salles; Paulo Bofetta; Lenka Foretova; Anthony Staines; Scott Davis; Richard K Severson; Qing Lan; Angela Brooks-Wilson; Martyn T Smith; Eve Roman; Anne Kricker; Yawei Zhang; Peter Kraft; Stephen J Chanock; Nathaniel Rothman; Patricia Hartge; Christine F Skibola
Journal:  Cancer Res       Date:  2018-05-07       Impact factor: 13.312

7.  Discovering novel disease comorbidities using electronic medical records.

Authors:  Shikha Chaganti; Valerie F Welty; Warren Taylor; Kimberly Albert; Michelle D Failla; Carissa Cascio; Seth Smith; Louise Mawn; Susan M Resnick; Lori L Beason-Held; Francesca Bagnato; Thomas Lasko; Jeffrey D Blume; Bennett A Landman
Journal:  PLoS One       Date:  2019-11-27       Impact factor: 3.240

8.  Positive association between actinic keratosis and internal malignancies: a nationwide population-based cohort study.

Authors:  Young Bok Lee; Ji Hyun Lee; Yeong Ho Kim; Ji Min Seo; Dong Soo Yu; Yong Gyu Park; Kyung Do Han
Journal:  Sci Rep       Date:  2021-10-05       Impact factor: 4.379

9.  Pigmentary traits, sun exposure, and risk of non-Hodgkin's lymphoma/chronic lymphocytic leukemia: A study within the French E3N prospective cohort.

Authors:  Louis-Marie Garcin; Amandine Gelot; Roselyn-Rima Gomez; Gaëlle Gusto; Marie-Christine Boutron-Ruault; Marina Kvaskoff; Gianluca Severi; Caroline Besson
Journal:  Cancer Med       Date:  2020-11-21       Impact factor: 4.452

10.  Impaired Immune Health in Survivors of Diffuse Large B-Cell Lymphoma.

Authors:  Tanaya Shree; Qian Li; Sally L Glaser; Ann Brunson; Holden T Maecker; Robert W Haile; Ronald Levy; Theresa H M Keegan
Journal:  J Clin Oncol       Date:  2020-02-21       Impact factor: 50.717

  10 in total

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